Water Contamination and Health : Integration of Exposure Assessment, Toxicology, and Risk Assessment book cover
1st Edition

Water Contamination and Health
Integration of Exposure Assessment, Toxicology, and Risk Assessment

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ISBN 9780824789220
Published March 30, 1994 by CRC Press
544 Pages

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Book Description

This volume examines every potential means of exposure to water contaminants, provides in-depth discussions on toxicology, and explains up-to-date techniques for evaluating human health risk. It develops a methodology for assessing the cumulative absorbed dose of contaminants through all routes of exposure, including ingestion, inhalation and dermal. Federal and state efforts to monitor and treat water are examined.

Table of Contents

Part 1 Water Contaminants - Monitoring, Treatment, and Health Impact: A Retrospective on Drinking Water. Chemicals in California Drinking Water - Source of Contamination, Risk Assessment and Drinking Water Standards. Reactions of Drinking Water Contaminants with Aqueous Chlorine and Monochloramine. Part 2 Exposure Assessment of Water Contaminants - Specific Dosimetry on Radon and Chloroform: Benefit of Deriving Drinking Water Standards Based on Comprehensive Assessments of Exposure. Chloroform Exposure and the Body Burden Associated with Swimming in Chlorinated Pools. Percutaneous Absorpton of Chemicals from Water Simulating Swimming and Bathing and from Vapour Exposure. A Comparison of Two Pathways to Human for Radon from Drinking Water - Inhalation and Ingestion. Part 3 Methodology Development and Exposure Assessment and Dose Estimates: Use of Pharmacokinetic Models to Estimate Internal Dose from Exposure. Pharmacokinetic Interactions of Drinking-Water Contaminants. Need for Physiologically-Based Toxicokinetic Models in Estimating Target Organ Dosage Following Oral Ingestion of Cadmuim. Estimating Dermal and Inhalation Exposure to Volatile Chemicals in Domestic Water. Percutaneous Absorption of Dilute Aqueous Chlorinated Organic Solvents in the Hairless Guinea Pig. Predictive Model for Dermal Exposure Assessment. Part 4 Human Health Risk Assessment and Water Contaminants: Estimating Human Health Risks for Trichloroethylene, a Water Contaminant, Using Physiological Models. Risk Assessment Based on Data from the Toxic Chemical Release Inventory. Empirical Comparisons of Carcinogen Potencies Across Species and Their Bearing on Appropriate Scaling of Doses for Risk Assessment. Modelling Risks from Water Contaminants - The Application of Concentration-Response Models. Part 5 Epidemiological Evaluation of Water Contaminants and Toxicological End Points. (Part contents).

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