Molecular and Cellular Biology
Written by the top Yersinia specialists, the book reviews the molecular biology of these important organisms and comprehensively covers recent advances in the field. Topics include genetic diversity in Y. pestis, quorum sensing, identification of virulence genes, regulation of virulence elements, superantigens, host invasion, host immune response, LPS structure and genetics, flagellar-dependent motility, flagellar-dependent protein secretion, iron or heme transport systems, Yersinia pathogenicity Islands, the Yop effector proteins, plasminogen activator (Pla), F1 antigen, and the conjugative plasmid pVM82.
Table of Contents
1. The Yersinia Pestis Chromosome. 2. Age, Descent and Genetic Diversity Within Yersinia pestis. 3. The Yersinia Pestis-Specific Plasmids pFra and pPla. 4. The Evolution of Flea-borne Transmission in Yersinia Pestis. 5. N-Acylhomoserine Lactone-Mediated Quorum Sensing in Yersinia. 6. The Invasin Protein of Enteropathogenic Yersinia Species: Integrin Binding and Role in Gastrointestinal Diseases. 7. Transcriptional Regulation in Yersinia: An Update. 8. Identification of Yersinia Genes Expressed During Host Infection. 9. Immune responses to Yersinia. 10. Superantigens of Yersinia pseudotuberculosis. 11. Lipopolysaccharides of Yersinia. 12. Flagella: Organelles for Motility and Protein Secretion. 13. Iron and Heme Uptake Systems. 14. The High-Pathogenicity Island: A Broad-host-range Pathogenicity Island. 15. YAPI, A New Pathogenicity Island in Enteropathogenic Yersiniae . 16. The pYV Plasmid and the Ysc-Yop Type III Secretion System. 17. The Plasminogen Activator Pla of Yersinia pestis: Localized Proteolysis and Systemic Spread. 18. Structure Assembly and Applications of the Polymeric F1 Antigen of Yersinia pestis. 19. pVM82: A Conjugative Plasmid of the Enteric Yersinia That Contributes to Pathogenicity.
It is accurate, thorough and for a book of this type, up-to-date. A credit to all contributors. This book is a must for Yersiniologists, but may also have wider appeal for researchers interested in biodefence, microbial genomics and the evolution of microbial virulence. - Brendan Wren, London School of Hygiene & Tropical Medicine
It is a contributive and solid foundation on which to base continuous bibliographic updating in a bacterial field evolving at least as fast as the Yersinia speicies themselves - Clinical Infectious Diseases, 2004:41, 15 December