BiographyDr. Simon is the principal and owner of Ted Simon, LLC, providing scientific support to a select group of clients. Dr. Simon has provided consulting services to clients that include large and small private sector companies, industry trade groups, environmental assessment and remediation firms, attorneys, state, federal and international regulatory agencies, university faculty and others. He provides scientific and policy support in the areas of toxicology, environmental risk assessment, mathematical modeling, product liability, statistics, drug and alcohol abuse, and other issues. He is knowledgeable in the area of adverse outcome pathways (AOPs) adopted by the Organisation of Economic Cooperation and Development (OECD) as a risk assessment tool. He has taught graduate level university courses and private/public sector short courses in risk assessment, statistics and simulation modeling. He has provided litigation support as expert testimony and consultation for both private sector clients and EPA.
As a consulting scientist, Dr. Simon has worked on environmental and toxicological issues related to dioxin, PAHs, PCBs, endocrine disruptors, and metals. He has provided advice to attorneys regarding environmental risk, accidental poisoning, intellectual property issues related to chemical products, and alcohol and substance abuse issues. He has performed pro bono work for the Georgia Department of Natural Resources and the International Life Sciences Institute and others.
Previously, Dr. Simon was employed for twelve years by the Environmental Protection Agency, Region 4, in Atlanta, serving as the senior toxicologist in the Waste Management Division. There, he developed national and regional guidance in the areas of probabilistic risk assessment, soil cleanup, statistics and toxicology.
Areas of Research / Professional Expertise
Toxicology, Risk Assessment, Mystery/Suspense Novels
- two grandchildren, Elizabeth, 2 yr and Charley, 2 mo.
- Author of "A Lost Gun" under the pen name Wix Simon
- others to follow
- fan of Cormac McCarthy, Elmore Leonard and James Lee Burke
- plays in bands and solo at outdoor events, e.g. farmers' markets, etc.
Traditional Black and White Photography
- has a wet darkroom in the basement
Published: Jan 02, 2014 by Crit Rev Toxicol
Authors: Budinsky, RA, Schrenk D, Simon T, Van den Berg M, et al.
Subjects: Biomedical Science
A mode of action was developed for rodent liver tumor promotion by dioxin-like chemicals. The aryl hydrocarbon receptor (AHR) has been implicated as a key component in this tumor promotion response. Despite extensive knowledge of the toxicology of dioxins, no mode of action (MOA) hypothesis for their tumorigenicity has been formally documented. To address this information gap, an expert panel was convened as part of a workshop on receptor-mediated liver tumorigenicity.
Published: Jan 03, 2013 by Regul Toxicol Pharmacol
Authors: Patlewicz G, Simon T, Goyak K, Phillips RD, Rowlands, JCR, Seidel S and Becker RA
Subjects: Biomedical Science, Pharmaceutical Science & Regulation
Advances in high throughput and high content (HT/HC) methods used in the fields of toxicogenomics, bioinformatics, and computational toxicology have the potential to improve both the efficiency and effectiveness of toxicity evaluations and risk assessments.However, scientific confidence in these methods should be formally established prior to use. Traditional validation approaches may not be readily applicable, and we present constructs to address the validation challenges of HT/HC methods.
Published: Apr 05, 2011 by Human and Ecological Risk Assessment
Authors: Kirman C, Budinsky, RA, Yost L, Baker BF, Zabik JM, Rowlands JC, Long TF, Simon T
Subjects: Biomedical Science
This article derives residential soil clean-up levels accounting for ingestion and dermal contact (direct contact criteria [DCC]) for a chlorinated dibenzo-p-dioxin and furan (PCDD/F as toxicity equivalence TEQD/F) impacted site using site-specific information and deterministic and probabilistic methods. This article presents and applies toxicity values seeking to address the NAS recommendations regarding cancer risk assessment.
Published: Jul 29, 2010 by Toxicological Sciences
Authors: Budinsky RA, LeClyuse EL, Ferguson SS, Rowlands JC, Simon T
Subjects: Biomedical Science
The concentration dose response for aryl hydrocarbon receptor (AHR)-mediated CYP1A1 and CYP1A2 messenger RNA (mRNA) induction and enzyme activity was determined in primary cultures of rat and human hepatocytes for 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrachlorodibenzofuran. Eleven different congener concentrations from 0.00001 to 100nM were used, thus spanning seven orders of magnitude. . No-observed effect concentration values were derived.
Published: Jul 29, 2010 by Human and Experimental Toxicology
Authors: Simon T
Subjects: Biomedical Science, Environmental Science, Public Administration & Public Policy
The willingness to view risk as part of daily life has vanished. A risk-averse mindset among environmental regulators engenders confusion between the ethics of intention and the ethics of consequence, leading to the elevation of the precautionary principle with unintended and often unfortunate outcomes. Environmental risk assessment is conservative, but the actual level of conservatism cannot be determined. Many assumptions obscure the actual degree of conservatism in risk assessments.
Published: Sep 23, 2009 by Toxicological Sciences
Authors: Simon T, Kirman, CR, Aylward LL, Budinsky RA, Rowlands JC
Subjects: Biomedical Science, Life Science, Occupational Health & Safety
Linear and nonlinear toxicity criteria were derived for 2,3,7,8- tetrachlorodibenzo(p)dioxin (TCDD) using the recent National Toxicology Program rat cancer bioassay. Dose-response relationships were assessed for combined liver tumors based on lifetime average liver concentrations (LALCs) estimated with a toxicokinetic model. Both a non-linear reference dose and a linear cancer slope factor were developed. The reference dose is consistent with a 2006 NRC recommendation and EPA's Cancer Guidelines
By: Ted Wix Simon
Subjects: Pharmaceutical Science & Regulation
Dr. Simon participated in the IRIS bimonthly meeting at which EPA staff in the IRIS program discussed the ongoing toxicity assessments for hexavalent chromium and inorganic arsenic.
Published: Sep 22, 2014
Dr. Ted Simon presents a talk on the Adverse Outcome pathway for aryl hydrocarbon receptor activation leading to rodent liver tumor promotion at NIH in Bethesda, MD on Sept. 3, 2014.