1st Edition
Lycopene Nutritional, Medicinal and Therapeutic Properties
Tomatoes have become a dietary staple for humans in many parts of the world. The characteristic deep red color of the ripe tomato fruit and related products is mainly due to lycopene. Lycopene is the predominant carotenoid in tomatoes, followed by a-carotene, b-carotene, g-carotene, and phytoene, as well as by several other minor carotenoids. Tomatoes and tomato-based foods have long been an important source of lycopene in the Western diet. There has been a growing interest in exploring the role of lycopene in the prevention of a variety of nutritional and health issues in humans, including some cancers and cardiovascular diseases. Recently, many case studies using cell cultures, animal models, and epidemiological investigations have shown a relationship between lycopene intake and a lowered risk of contracting some cancers and various chronic diseases. Increasingly, clinical evidence supports the role of lycopene as a nutrient with important health benefits, since it appears to provide protection against a broad range of epithelial cancers. The possibility that consumption of lycopene-rich foods may reduce the risk of such diseases has prompted numerous in-depth studies of the levels of lycopene in foods and of correlations between dietary lycopene and certain diseases. This monograph will serve as a reference for providing a better understanding of the role of lycopene in promoting health, and by encouraging a deeper understanding of approaches to a healthy diet and life.
Foreword
Preface
List of Contributors
CHARACTERIZATION OF LYCOPENE FROM CHEMISTRY TO BASIC PHYSIOLOGICAL FUNCTIONS
Lycopene Overview: What It Is and What It Does Robert M. Diener and Mildred S. Christian
Stability of Lycopene during Food Processing and Storage John Shi and Sophia Jun Xue
Lycopene Metabolites: Apo-lycopenals Nikki A. Ford and John W. Erdman, Jr.
Non-covalent Binding of Lycopene and Lycophyll Zsolt Bikadi, Peter Hari, Eszter Hazai, Samuel F. Lockwood and Ferenc Zsila
Risk Assessment of Lycopene Andrew Shao and John N. Hathcock
BIOCHEMICAL AND PHYSIOLOGICAL FEATURES OF LYCOPENE’S EFFECTS
Lycopene and Peroxynitrite Modifications Kaampwe Muzandu, Kennedy Choongo and Shoichi Fujita
Lycopene and Down-regulation of Cyclin D1, pAKT and pBad Rosanna Sestito and Paola Palozza
Lycopene and Chylomicrons Kathleen M. Botham and Elena Bravo
Lycopene and Chromosomal Aberrations Lusânia Maria Greggi Antunes and Maria de Lourdes Pires Bianchi
Lycopene and Lycopene-enriched Prostasomes Anuj Goyal, Mridula Chopra and Alan Cooper
Topically Applied Lycopene and Antioxidant Capacity Marco Andreassi and Lucio Andreassi
Lycopene and Cardiovascular Diseases Martha Verghese, Rajitha Sunkara, Louis Shackelford and Lloyd T. Walker
Effects of Lycopene and Monounsaturated Fat Combination on Serum Lycopene, Lipid and Lipoprotein Concentrations Kiran Deep Kaur Ahuja and Madeleine Joyce Ball
Lycopene: Cataract and Oxidative Stress S.K. Gupta, Sushma Srivastava, Renu Agarwal and Shyam Sunder Agrawal
Lycopene and Bone Tissue L.G. Rao, E.S. Mackinnon and A.V. Rao
LYCOPENE AND CANCER
Lycopene and Its Potential Role in Prostate Cancer Prevention A. Trion, F.H. Schröder and W.M. van Weerden
Lycopene and Urokinase Receptor Expression in Prostate Cancer Cells Inder Sehgal
Lycopene and Lung Cancer Fuzhi Lian and Xiang-Dong Wang
Breast Cancer and Lycopene Nasséra Chalabi, Yves-Jean Bignon and Dominique J. Bernard-Gallon
Lycopene and Colon Cancer Martha Verghese, Judith Boateng, Louis Shackelford and Lloyd T. Walker
Index
Color Plate Section
Biography
Preedy, V R ; Watson, Ronald R.