1st Edition

A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

Edited By Franz Joel Leong, Veronique Dartois, Thomas Dick Copyright 2010
    236 Pages 100 Color Illustrations
    by CRC Press

    236 Pages
    by CRC Press

    An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, students, scientists, and doctors working, learning, and teaching in the field of TB. It contains 100 color photographs and illustrations that bring clarity to the information presented.

    The atlas takes the unusual approach of covering multiple species histopathology, arguably the first and quite possibly the only resource to do so. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists to distinguish between the features of all major animal models available and to use them with their strengths and limitations in mind. The book provides guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates.

    Drug Discovery for Neglected Diseases of the Developing World, P. Herrling
    Background
    The Drug Discovery Process
    Therapeutic Tools
    Drug Discovery Phases
    Phase I–Phase IIa
    Phase IIb–Phase III
    References

    Tuberculosis Biology and Drug Discovery, T. Dick
    Disease Manifestations and Treatment
    A Largely Unment Medical Need
    The Challenge of TB Drug Discovery
    An At las for TB Drug Discovery
    References

    Immunopathology of Tuberculosis Disease across Species, V. Dartois
    Overview of Species Specific Characteristics
    A Macroscopic View of TB-Infected Lungs across Species
    Summary and Lessons Learned
    References

    Anatomy and Histology of the Human Lung, F.J.W.-M. Leong and A. S.-Y. Leong
    Gross Structure
    Microscopic Structure
    References

    Pathology of Tuberculosis in the Human Lung, F.J.W.-M. Leong, S. Eum, L.E. Via, and C.E. Barry, 3rd
    Introduction
    Features
    Variations
    References

    Pulmonary Tuberculosis in Monkeys, J.L. Flynn and E. Klein
    Introduction
    Inoculum and Route of Infection
    Features
    Variations
    Strengths of This Animal Model
    Shortcomings
    References

    Pulmonary Tuberculosis in the Rabbit, G. Kaplan and L. Tsenova
    Introduction
    Inoculum and Route of Inoculation
    Features
    Strengths of This Animal Model
    Shortcomings
    References

    Pulmonary Tuberculosis in the Guinea Pig, R.J. Basaraba and I.M. Orme
    Introduction
    Inoculum and Route of Inoculation
    Features
    Strengths of This Animal Model
    Shortcomings
    References

    Pulmonary Tuberculosis in the Rat, A. Singhal, E.M. Aliouat, C. Creusy, G. Kaplan, and P. Bifani
    Introduction
    Inoculum and Route of Inoculation
    Features
    Variations
    Strengths of This Animal Model
    Shortcomings
    References

    Pulmonary Tuberculosis in the Mouse, S. Bharath and V. Balasubramanian
    Introduction
    Inoculum and Route of Inoculation
    Features
    Variations
    Strengths of This Animal Model
    Shortcoming
    References

    Glossary
    Index

    Biography

    Franz Joel Leong, Veronique Dartois, Thomas Dick

    "This book is an excellent introduction to pulmonary tuberculosis and the physiologic, pathologic, and political hurdles as to why it has been such a difficult disease to contend with. The authors explain the intricacies of the tuberculin bacterium, the host defenses, and the theories behind current treatment modalities.
    The atlas is designed as a concise resource for researchers working in the field and the laboratory to evaluate the pulmonary pathologic response to the Mycobacterium organism and design more successful treatment and disease eradication for human and animal species. The multitude of photomicrographs and gross pathology photographs are of excellent quality and well-labeled. The text is well written, organized in an easy to read format, and well-referenced for further research."
    —Sandra L. Jex, DVM, in alnmag.com