1st Edition

Calcium Signalling in Cancer

By G. V. Sherbet Copyright 2001
    382 Pages 28 B/W Illustrations
    by CRC Press

    Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feature of cell adhesion and motility; the integrity of the calcium binding proteins themselves is a basic requirement of normal biological function. In fact, the deregulation of calcium signaling is now regarded as the primary event in the pathogenesis, growth, invasion, and secondary spread of cancer.

    Calcium Signalling in Cancer is a concise up-to-date treatise on the transduction signals induced by calcium that considers how alterations in this calcium-dependent signal transduction pathway are related to a number of human diseases, especially neoplastic transformation. This authoritative text examines a broad range of topics-from mechanisms and significance of calcium homeostasis for normal cell function to calcium signalling pathways and the transduction of the calcium signal, especially in proliferation, cell motility, cancer invasion,, and metastasis.

    Clearly organized, it covers all aspects of the subject including specific sections on the regulation of the genes whose products are required for signal transduction by calcium, such as Alzheimer's disease, Darier's disease, Duchenne and limb girdle dystrophies, psoriasis and some forms of ichthyosis, and cancer associated retinopathy. With an extensive bibliography and over 2,500 references, Calcium Signalling in Cancer is an invaluable reference source.

    Preface

    Abbreviations

    Introduction

    The Calcium Signalling Pathway
    Homeostasis of Cell Calcium
    Phospholipid Signalling
    PTEN Phosphatase in the Regulation of Lipid
    Signalling
    The Protein Kinase C Pathway
    Protein Kinase C and Its Isoforms in Signal
    Transduction
    Inositol Phosphates in Signal Transduction
    Deregulation of Inositol 1,4,5-Trisphosphate Pathway
    and Its Consequences
    Ryanodine and Related Receptors in Calcium
    Mobilisation
    Cyclic AMP in Calcium Signalling
    Architectural Aspects of the Signal Transduction
    Machinery

    Calcium Binding Proteins and Their Natural Classification
    Non-EF-Hand Calcium Binding Proteins
    Annexins
    The Gelsolin Family Calcium Binding Proteins
    Calreticulin and Its Functional Diversity
    Calsequestrin and Intracellular Calcium Storage
    Osteocalcin in Bone Metabolism and Osteotropism
    of Cancer

    The EF-Hand Calcium Binding Proteins
    Molecular Organisation of Calcium Binding EF Hand
    Proteins
    Calcium Binding and the Molecular Configuration of
    Calcium Binding Proteins
    The Structure and Organisation of S100 Family
    Genes
    Alternatively Spliced Variants of S100A4
    Functional Significance of Alternatively Spliced
    Isoforms
    Regulation of Expression of S100 Family Genes

    The Calmodulin Family of Calcium Binding Proteins
    Calmodulin and its Physiological Function
    Recoverin Subfamily of Neural Calcium Binding
    Proteins and Their Function
    Guanylate Cyclase Activating Proteins

    The Structure of Contractile Proteins
    The Actin Component of Contractile Machinery of the
    Cell
    The Role of Thymosin Family Actin-Binding Proteins in Actin Dynamics
    The Fimbrin Family of Actin-Binding Proteins
    a-Actinin
    Myosin Filaments
    Troponins and Tropomyosins in the Regulation of
    Muscle Cell Contraction

    The Structure and Biology of Calbindin
    Calbindin in Neuronal Populations
    Neural Cell Lineage and the Regulation of Calbindin Expression
    Calbindin Expression in Embryonic Development and Ageing
    Physiological Function of Calbindin
    Neuroprotective Function of Calbindin
    Calbindin Expression and the Metastatic Phenotype

    Calretinin: Its Role in Cell Differentiation and as a Potential
    Tumour Marker
    Calretinin and Its Alternatively Spliced Isoforms
    Regulation of Calretinin Expression
    Calretinin Expression in Cell Proliferation and Differentiation
    Calretinin and Its Possible Neuroprotective Property
    Calretinin as a Potential Tumour Marker

    Calcineurin in Cell Proliferation, Cell Adhesion, and Cell Spreading
    Molecular Features of Calcineurin
    Calcineurin in Cell Proliferation and Adhesion-Related Phenomena
    Calcineurin in Alzheimer's Disease
    Calcineurin in Immunosuppression

    Centrins (Caltractins) and Their Biological Functions
    Reticulocalbin Family of EF-Hand Proteins
    Molecular Features of Reticulocalbin Homologues
    Putative Functions of Reticulocalbin and Its Homologues

    Calpains in Normal and Aberrant Cell Physiology
    The Calpain Family of Calcium-Binding Proteins
    Molecular Organisation of Calpains
    Regulation of Physiological Events by Proteolytic Function
    Involvement of Calpains in Development and Differentiation
    Calpains in Cell Proliferation and Apoptosis
    Calpains in Cell Spreading and Migration
    Calpains in Integrin-Mediated Cell Adhesion and Signal Transduction
    Calpains in Cancer Growth and Progression
    Calpains in Myelodegenerative Diseases
    Calpains in Muscular Dystrophy

    Caspases in Apoptosis, Cell Migration. Proliferation, and
    Neoplasia
    Caspases in Apoptotic Cell Death
    Poly (ADP-Ribose) Polymerase as a Marker of Apoptosis
    Caspase-Mediated Apoptosis and Cell Growth Inhibition in Tumour Expansion
    Caspase-Mediated Proteolysis of Fodrin: Implications for Apoptosis, Cell Adhesion, Cell Migration, and Neoplastic Transformation
    Caspases and Neuronal Loss in Alzheimer's Disease

    Parvalbumins In Neuronal Development, Differentiation, and Proliferation
    Osteonectin In Cell Function And Behavior
    Molecular Structure of Osteonectin
    Functions and Functional Domains of Osteonectin
    Regulation of Osteonectin Expression
    Osteonectin in the Remodeling of the Extracellular Matrix
    Osteonectin in Embryonic Development and Differentiation
    Modulation of Cellular Adhesion, Cell Shape, and Motility by Osteonectin
    Modulation of Cell Proliferation by Osteonectin
    Effects of Osteonectin on Angiogenesis
    Osteonectin Expression in Cancer Development and Progression
    Osteonectin Involvement in Other Disease States
    Osteonectin Homologues and Their Putative Tumour Suppressor Properties

    S100 Proteins: Their Biological Function And Role In
    Pathogenesis
    S100 Proteins in Cell Differentiation, Motility, and
    Cancer Invasion
    Effects of S100 Proteins in Cell Deformability and Cellular Morphology
    S100A Isoforms
    S100A2 As A Putative Tumour Suppressor
    S100A3 Expression in Cell Differentiation and Neoplasia
    S100A4 in Cancer Development and Progression
    S100A6 (Calcyclin) in Cancer
    The Biological Properties of S100A7 (Psoriasin)
    Structure and Molecular Properties of S100A7
    S100A8 and S100A9 Proteins in Inflammatory Diseases
    S100A11 (S100C) and Possible Modes of Its Function
    S100P in Cancer Progression
    Potential Value of S100 Proteins As Markers of Cancer Progression and Prognosis

    Epilogue

    References

    Index

    Biography

    G. V. Sherbet