This book is intended to give readers a “quick look” at metabolic and endocrine physiology. Emphasis is placed on instructional figures, flow diagrams and tables, while text material has been held to a minimum. In general, the endocrine system is first defined and described, and then each endocrine gland is discussed separately. Where appropriate, common endocrine disorders have also been included. This text concisely elucidates the endocrine mechanisms responsible for maintaining homeostatic control of important physiologic variables, and to assist the reader in understanding common pathophysiologic deviations from normal. Over 360 multiple-choice questions gauge the reader’s capacity to effectively understand the subject material.
This new edition contains six new chapters covering: hormone disposition, measurement and secretion; bovine, equine and rodent estrus cycles; primate menstrual cycle; male reproductive system; testosterone, estrogen and progesterone; comparative aspects of endocrinology. Learning objectives have been added at the beginning of each chapter and all of the questions are new.
Endocrine System
Overview
Endocrine Secretory Control
Autocrine, Paracrine, and Endocrine Mediators
Hormone Disposition, Measurement and Secretion
Production & Distribution Volume,Clearance & Immunoassay
Mechanisms of Catecholamine and Polypeptide Hormone Action: I
Receptors and Second Messengers
Mechanisms of Catecholamine and Polypeptide Hormone Action: II
The Intracellular Ca2+/DG Messenger System
Steroid and Thyroid Hormones
Mechanisms of Action
Hypothalamus and Pituitary
Directors of the Endocrine Orchestra
Proopiomelanocortin and Related Peptides: I
Endogenous Opiate-Like Peptides
Proopiomelanocortin and Related Peptides: II
Melanocyte-Stimulating Hormone
Growth Hormone: I
Actions and Secretory Control
Growth Hormone: II
Hypo- and Hypersomatotropism
Antidiuretic Hormone
Vasopressin
Diabetes Insipidus
Central and Nephrogenic
Calcium
Physiologic Actions.
Magnesium and phosphate
Physiologic Actions
Parathormone, Calcitonin, and Vitamin D: I
PTH, PTHrp, and CT
Parathormone, Calcitonin, and Vitamin D: II
CT and 1,25(OH)2D
Disorders of Calcium Homeostasis
Hyper- and Hypocalcemia
Mineral Imbalances: I
Na+, K+, PO43, and Mg2+
Mineral Imbalances: II
Parturient Hypocalcemia and Osteoporosis
ACTH and Glucocorticoids: I
Corticosteroidogenesis and Degradation
ACTH and Glucocorticoids: II
ACTH Secretion and Action
ACTH and Glucocorticoids: III
Organ and Tissue Effects) 46ACTH and Glucocorticoids: IV (Physiologic and Pharmacologic Actions
Cushing's-Like Syndrome and Disease
Glucocorticoid Excess
Mineralocorticoids
Effects on Na+, K+ and H+
Renin-Angiotensin System: I
The Juxtaglomerular Apparatus
Renin-Angiotensin System: II
Hypertension
Addison’s-Like Disease
Hypoadrenocorticism
Erythropoietin
Production and Action
Natriuretic Peptides
ANP, BNP, CNP, and Urodilatin
Adrenal Medulla: I
Catecholamine Biosynthesis and Degradation
Adrenal Medulla: II
Adrenergic Receptors and the Sympathoadrenal Response
Pheochromocytoma
Catecholamine-Secreting Tumor
Phasic Responses to Trauma
Immediate, Catabolic, and Anabolic
Thyroid: I
Hormone Biosynthesis and Secretory Regulation
Thyroid: II
Metabolic Effects of Thyroid Hormones
Hypothyroidism
Signs and Symptoms
Hyperthyroidism
Signs and Symptoms
Endocrine Pancreas: I
The Islets of Langerhans
Endocrine Pancreas: II
Regulation of Insulin Release
Insulin
Actions and Degradation
Glucagon
Biosynthesis and Metabolic Actions
Diabetes Mellitus
The “Pissing Evil"
Acute Insulin Withdrawal: I
Carbohydrate and Lipid Metabolism
Acute Insulin Withdrawal: II
Protein Metabolism and Electrolyte Depletion
Gastrointestinal Hormones: I
Introduction and Historical Perspective
Gastrointestinal Hormones: II
Gastrins
Gastrointestinal Hormones: III
Gastric HCl Secretion, and CCK
Gastrointestinal Hormones: IV
Secretin and other GI Peptides
APUDomas
Neuroendocrine Tumors of the Gut)
Reproductive Endocrinology
Introduction
Estrous Cycles
Types and Phases
Ovine, Canine and Feline Estrous Cycles
Endocrine Parameters
Bovine, Equine and Rodent Estrous Cycles
Endocrine Parameters
Primate Menstrual Cycle
Endocrine Parameters
Menstruation and Regulation of Gonadotropin Release
Control of the GnRH Pulse Generator
Spermatogenesis and Ovulation
Gonadotropin Control
Male Reproductive System
The Testes and Accessory Sex Glands
Testosterone, Estrogen and Progesterone
Biosynthesis, Metabolism and Functions
Pineal Gland: I
Photoperiodic Regulation of Reproductive Events
Pineal Gland: II
Nonreproductive Actions of Melatonin
Placental Hormones
Fertilization, the CL and Placenta
Fetal Endocrine System: I
The Fetoplacental Unit
Fetal Endocrine System: II
Glandular Development
Maternal Endocrine System
Functional Alterations during Pregnancy.
Maternal Organ Systems
Patterns of Change
Mammary Glands
Mammogenesis and Lactation
Prolactin
Secretory Control and Physiologic Actions
Oxytocin
Physiologic Actions
Neonatal Physiology: I
Thermal, Nutritional, and Cardiovascular Adaptations)
Neonatal Physiology: II
Organ System Development
Comparative Aspects of Endocrinology
Appendix
Blood Chemistry Values for Domestic Animals
Reproductive Patterns of Domestic Animals
Basic Physiological Units
Learning Objectives,
Study Questions and Answers
References
Index
Contents
Biography
Larry Engelking
