3rd Edition

Recurrent Pregnancy Loss Causes, Controversies and Treatment

Edited By Howard Carp Copyright 2020
    312 Pages 58 B/W Illustrations
    by CRC Press

    Major advances in genetics, immunology, and endocrinology have necessitated a new edition of this best-selling text. However, despite the advances, recurrent pregnancy loss presents a frustrating clinical problem. There is still disagreement about the number of pregnancy losses which warrant investigation and treatment and about which investigations should be performed.

    This third edition provides an authoritative and comprehensive update on advances in the understanding and management of this troubling phenomenon, covering both basic scientific topics such as genetics and cytokines, and profiles major advances in immunology, endocrinology, and thrombotic mechanism. Clinical research is discussed, as is assessment of results when applying an evidence-based approach or a more personalised approach, which is now becoming possible due to advances in the diagnosis of cause. There are lively debates on the role of progestogens and immunotherapy, which remain controversial.

    Designed for specialists working in reproductive medicine clinics and those involved with maternal-fetal care, the book is also ideal for generalists and gynecologists seeking a comprehensive view of developments in the field.

    Part I: Basic Principles

    1 The Epidemiology of Recurrent Pregnancy Loss

    Ole B. Christiansen

    2 The Signaling between Embryo and Mother as a Basis for the Development of Tolerance

    Eytan R. Barnea

    3 Recurrent Pregnancy Loss: From Evidence-Based to Personalized Medicine

    Howard J.A. Carp

    Part II: Etiology

    4 The Genetics of Spontaneous Abortions

    Joe Leigh Simpson

    5 The Endometrial Factor in Recurrent Pregnancy Loss

    Luiza Borges Manna and Ying Cheong

    6 Fetal Structural Malformations and Recurrent Pregnancy Loss

    Howard J.A. Carp, Tomas Philipp, Micha Baum, and Michal Berkenstadt

    7 The Endocrinology of Recurrent Pregnancy Loss

    Nicola Pluchinoi, Serena Bellaminutti, Panagiotis Drakopoulos, Antonis Makrigiannakis, and Andrea R Genazzani

    8 The Etiology of the Antiphospholipid Syndrome

    Sara De Carolis, Giuseppina Monteleone, Rotem Inbar, Cristina Garufi, Miri Blank, and Yehuda Shoenfeld

    9 Defects in Coagulation Factors Leading to Recurrent Pregnancy Loss

    Aida Inbal and Howard J.A. Carp

    10 The Immunobiology of Recurrent Miscarriage

    Marighoula Varla-Leftherioti. Theodora Keramitsoglou, and Christina Tsekoura

    11 Immune Testing in Recurrent Pregnancy Loss

    Jeffrey Braverman, Darren Ritsick, and Nadera Mansouri-Attia

    12 Uterine Anomalies andRecurrent Pregnancy Loss

    Daniel S. Seidman and Mordechai Goldenberg

    13 The Male Factor in Recurrent Pregnancy Loss

    Catherine F. Ingram, Nannan Thirumavalavan, Marc Goldstein, and Delores J. Lamb

    Part III: The Developing Pregnancy

    14 Ultrasound Follow-Up in Early Pregnancy

    Akhila Vasudeva and Pratap Kumar

    15 Threatened Miscarriage and Recurrent Pregnancy Loss

    Howard J.A. Carp

    16 The Role of Cerclage and Pessaries

    Israel Hendler and Howard J.A. Carp

    17 What Genetic Screening Is Appropriate in Recurrent Pregnancy Loss?

    Howard Cuckle

    18 Obstetric Outcomes after Recurrent Pregnancy Loss

    Rakefet Yoeli-Ullman, Howard J.A. Carp, and Shali Mazaki-Tovi

    Part IV: Management

    19 Investigation Protocol for Recurrent Pregnancy Loss

    Howard J.A. Carp

    20 Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? Yes

    Ashok Kumar and Simar Kaur

    21 Debate: Should Progestogens Be Used in Recurrent Pregnancy Loss? No

    Roy Mashiach

    22 Human Chorionic Gonadotropin Supplementation in Recurrent Pregnancy Loss

    Carlo Ticconi, Adalgisa Pietropolli, and C.V. Rao

    23 Antiphospholipid Syndrome: Management of the Obstetric Patient

    Ashley E. Benson and D. Ware Branch

    24 Can Recurrent Pregnancy Loss Be Prevented by Antithrombotic Agents?

    Audrey A. Merriam and Michael J. Paidas

    25 Empirical In Vitro Fertilization for Recurrent Pregnancy Loss: Is It a Valid Concept?

    Michal Kirshenbam and Raoul Orvieto

    26 Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? Yes

    Carmen M. Garcia-Pascual, Pilar Lopez, Nasser Al-Asmar, Pere Mir, Lorena Rodrigo, Carlos Simon, and Carmen Rubio

    27 Debate: Should PGT-A Still Be Performed in Recurrent Pregnancy Loss? No

    Raoul Orvieto and Norbert Gleicher

    28 Third Party Reproduction in Recurrent Pregnancy Loss

    Gautam Nand Allahbadia, Rubina Merchant, Akanksha Allahbadia Gupta, and A.H. Maham

    Part V: Immunotherapy

    29 Immunotherapy for Recurrent Pregnancy Loss

    Salim Daya

    30 IVIg treatment for Recurrent Pregnancy Loss

    Carolyn B. Coulam

    31 The Role of Filgrastrim

    Fabio Scarpellini and Marco Sbracia

    32 Opinion: Immunotherapy Has No Place in the Treatment of Recurrent Pregnancy

    Loss

    Micha Baum

    Biography

    Howard J.A. Carp, MB BS, FRCOG, is Clinical Professor, Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

    "a leading team … successfully reviews the controversies surrounding each topic… Essential reading for any physician counseling or treating women with recurrent pregnancy loss."

    European Gynecology & Obstetrics