1st Edition
Pharmaceutical Aspects of Oligonucleotides
336 Pages
by
CRC Press
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Oligonucleotides diffuse poorly through biological barriers, including cell membranes. They are also rapidly degraded in vivo by nucleuses. Aiming to improve the administration of compounds, the book studies the development of nucleotide chemistry.
1. Mechanisms of Action of Antisense Oligonucleotides D.M. Tidd and R.V. Giles 2. Chemistry of Oligonucleotides J.W. Engels and E. Uhlmann 3. The Oligonucleotide Prodrug Approach: The Pro-oligonucleotides F. Morvan, J.-J. Vasseur, E. Vivès, B. Rayner and J.-L. Imbach 4. Peptide Nucleic Acids P.E. Nielsen 5. Peptide-mediated Delivery of Oligonucleotides E. Vivès and B. Lebleu 6. Polymeric Nanoparticles and Microparticles as Carriers for Antisense Oligonucleotides E. Fattal and P.
Biography
Patrick Couvreur, Claude Malvy
