The consequences of early-onset brain damage for the development of cognition and behavior have recently been identified as top research priorities by the NINDS. This special issue presents a series of new empirical studies that address this issue in depth, from several different perspectives and in both human and animal participants. The focus is on the development of personality, social behavior, and related "executive functions," in subjects who suffered early damage to prefrontal brain regions. A consistent theme throughout is that early-onset prefrontal lesions can frequently lead to severe, intractable deficits in social behavior and moral reasoning and to impairments of executive functions, such as planning, judgment, and decision making.
Volume 18, Number 3, 2001
Contents: D. Tranel, P.J. Eslinger, The Effects of Early-Onset Brain Injury on the Development of Cognition and Behavior: Introduction to the Special Issue. S.W. Anderson, H. Damasio, D. Tranel, A.R. Damasio, Long Term Sequelae of Prefrontal Cortex Damage Acquired in Early Childhood. R.J. Eslinger, K.R. Biddle, Adolescent Neuropsychological Development After Early Right Prefrontal Cortex Damage. P.D. Connor, P.D. Sampson, F.L. Bookstein, H.M. Barr, A.P. Streissguth, Direct and Indirect Effects of Prenatal Alcohol Damage on Executive Function. J. Barrash, D. Tranel, S.W. Anderson, Acquired Personality Disturbances Associated With Bilateral Damage to the Ventromedial Prefrontal Region. G. Hanten, M. Bartha, H.S. Levin, Metacognition Following Pediatric Traumatic Brain Injury: A Preliminary Study. L. Malkova, J. Bachevalier, M. Webster, M. Mishkin, Effects of Neonatal Inferior Prefrontal and Medial Temporal Lesions on Learning the Rule for Delayed Nonmatching-to-Sample. B. Kolb, R. Gibb, G. Gorny, Cortical Plasticity and the Development of Behavior Aftern Early Frontal Cortical Injury. W.B. Marlowe, An Intervention for Children With Disorders of Executive Functions.