1st Edition

Advances in Isotope Methods for the Analysis of Trace Elements in Man

Edited By Malcolm Jackson, Nicola Lowe Copyright 2001

    There is increasing evidence that even minute amounts of trace elements can have profound effects on the human body. Advances in Isotope Methods for the Analysis of Trace Elements in Man describes new methods that are being developed to understand normal and abnormal trace element nutrition and metabolism.

    This book includes a wealth of practical advice, encompassing all aspects of isotope methodology, such as the latest developments of analysis techniques for both stable and radioactive isotopes, issues in study design, current cost of isotopes, and analysis. It provides both a historical review of what has been done in the past and details of current techniques and applications.

    > This state-of-the-art collection from leading experts in the field from Europe and the United States makes a strong case for the practice and advancement of this critical health care tool.

    ADVANCES IN STABLE ISOTOPE METHODOLOGY
    History
    Using Stable Isotopes to Study Trace Element Metabolism
    Stable Isotope Dosage, Preparation, and Administration
    Conducting Stable Isotope Tracer Studies
    ADVANCES IN RADIOISOTOPE METHODOLOGY
    Radioisotopes
    Whole-Body Counting Techniques
    Body Imaging Techniques
    Indirect Measurements of Absorption or Metabolism
    Concluding Remarks
    TRACER TO TRACEE RATIO FOR
    COMPARTMENTAL MODELING OF STABLE
    ISOTOPE DATA
    Introduction
    Single Pool Tracer Kinetics and Measurement
    Tracer to Tracee Ratio from Mass Spectrometry
    Measurements
    Multi Pool Tracer Kinetics and Measurement
    The Multiple Tracer Case
    A Test of the Endogenous Constant Steady State
    Assumption
    Software Tool: TTRM
    Conclusions
    METHODS FOR ANALYSIS OF TRACE ELEMENT
    ABSORPTION
    Introduction
    Iron
    Copper
    Zinc
    Selenium
    KINETIC STUDIES OF WHOLE BODY TRACE
    ELEMENT METABOLISM
    Introduction
    General Considerations in Study Design
    Compartmental Modeling
    Specific Examples of Isotope Turnover Studies
    Concluding Remarks
    STABLE ISOTOPE METHODS FOR THE
    INVESTIGATION OF IRON METABOLISM IN MAN
    Introduction
    Erythrocyte Incorporation and Iron Absorption
    Zinc
    Zinc and Copper
    Selenium
    Chromium
    Conclusions
    USE OF ISOTOPES IN THE ASSESSMENT OF ZINC STATUS
    Introduction
    Isotopic Techniques
    Conclusions
    COPPER STATUS AND METABOLISM STUDIED
    WITH ISOTOPIC TRACERS
    Introduction
    Background
    Copper Status
    Isotopic Tracers
    Conclusions
    USE OF STABLE ISOTOPES OF SELENIUM TO
    INVESTIGATE SELENIUM STATUS
    Introduction
    Dietary Selenium and Its Metabolism
    The Role of Selenium in the Body
    Assessment of Selenium Status and Use of Stable Isotopes
    Conclusions
    USE OF ISOTOPES FOR STUDIES WITH
    MANGANESE, CHROMIUM AND MOLYBDENUM
    Manganese
    Chromium
    Molybdenum
    Summary
    TRACE ELEMENT STUDIES IN INFANTS AND
    PREGNANT OR LACTATING WOMEN
    Introduction
    Iron
    Zinc
    Zinc and Copper
    Selenium
    Chromium
    Conclusions
    STABLE ISOTOPE STUDIES IN THE ELDERLY
    Introduction
    Practicalities of Working with Elderly Subjects
    Ethical Considerations
    Examples of Stable Isotope Studies in the Elderly
    Selenium Status of the Elderly
    Conclusions
    APPLICATIONS OF TRACE ELEMENT STUDIES IN DEVELOPING COUNTRIES: PRACTICAL AND TECHNICAL ASPECTS
    Introduction
    Applications of Isotope Studies in Developing
    Countries
    Practical Aspects of Implementing Isotope Studies in
    Developing Countries
    Technical Aspects of Implementing Isotope Studies in
    Developing Countries
    Conclusions

    Biography

    Nicola Lowe, Malcolm Jackson