Considering the fluid nature of nano breakthroughs—and the delicate balance between benefits and consequences as they apply to medicine—readers at all levels require a practical, understandable base of information about these developments to take greatest advantage of them. Medical Nanotechnology and Nanomedicine meets that need by introducing non-experts to nanomedicine and its evolving organizational infrastructure.
This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects—an ideal foundation upon which to plan and make decisions.
Covers the use of nanotechnology in medical applications including imaging, diagnosis and monitoring, drug delivery systems, surgery, tissue regeneration, and prosthetics
Part of the Perspectives in Nanotechnology series—which contains broader coverage of the societal implications of nanotechnology—this book can be used as a standalone reference. Organized by historical perspective, current status, and future prospects, this powerful book:
- Explores background, definitions and terms, and recent trends and forces in nanomedicine
- Surveys the landscape of nanomedicine in government, academia, and the private sector
- Reviews projected future directions, capabilities, sustainability, and equity of nanomedicine, and choices to be made regarding its use
- Includes graphical illustrations, references, and keywords to reinforce concepts and aid further research
In its assessment of alternative and sometimes conflicting concepts proposed for the application of nanotechnology to medicine, this book surveys major initiatives and the work of leading labs and innovators. It uses informative examples and case summaries to illustrate proven accomplishments and imagined possibilities in research and development.
Part I: Perspectives
Nanomedicine: Scientific Basis and Societal Implications
Medicine
Nanotechnology
What Is Nanoscience and Where Does It Fit in the Sciences?
Origins of Nanotechnology
Molecular and Cell Biology and Protein Bioscience: A Model of Life as Organic Nanomachinery
Nanotechnology Leads to a Fundamentally New Approach to Engineering Design
Societal and Economic Impacts
Impact of Nanotechnology on Medicine
The Grand Challenge of Nanotechnology
Some Definitions and Nanomedical Areas of Emphasis
Healthcare Crisis: How Can Nanotechnology Contribute to a Solution?
Historical Perspectives and Technological Breakthroughs
Brief Highlights of Nanomedicine History
Medical Milestones
Emerging National and Global Nanomedicine Initiatives
Some Developments in Nanomedicine
Current Examples of Nanomedicine in Practice and Research
NIH Nanomedicine Initiative
Putting Medical Nanoscience into Practice: Medical Nanotechnology and Nanomedicine
Part II: Beginnings of Medical Nanotechnology
Nanomedicine: Proposals and Promise
Introduction and Overview
Impacts of Nanotechnology on Medicine
An Overview of the Architecture of Medical Nanotechnology and Nanomedicine
Nanoscience: Bridging the Gap between Biochemistry and Cell Biology
Medication: Nanoparticles for Imaging and Drug Delivery
Introduction: The Emergence of Nanotechnology Applications in Medicine
Nanoparticles for Medical Imaging
Nanoparticles for Targeted Imaging and Delivery of Energy
Nanoparticles for Delivery of Drugs
Some Therapeutic Application Areas for Nanoparticles Theranostics
Conclusion: Nanomedicines Have a Broad Impact Throughout Medicine
Intervention: Nanotechnology in Reconstructive Intervention and Surgery
Nanoengineered Materials in Surgical and Restorative Applications
Bridging the Gap between Drugs and Surgery with Endoscopic MEMS
Robotics in Surgery: The Technology
Robotics in Surgical Practice
Recent Advances and Emerging Technologies in Surgical and Endoscopic Navigation
Summary of Translational Development of Nanoengineered Regenerative Tissue Therapy
Regeneration: Nanomaterials for Tissue Regeneration
Introduction: The Role of Nanotechnology in Tissue Regeneration
Biomaterials for Tissue Regeneration
Nanotechnology and Tissue Engineering
Tissue Engineering for Nerve Regeneration
Nanotechnology for Regeneration of the Brain
Use of Nanoengineered Scaffolding with Cells for Central Nervous System Regeneration
New Developments in Cell Therapy Accelerated by Nanoscience and Nanotechnology
Conclusion: Toward Clinical Therapies Based on Integrated Medical Nanoscience
Restoration: Nanotechnology in Tissue Replacement and Prosthetics
Nanoscale Biomaterials and Technologies for Tissue Engineering
Application of Tissue Engineering in Medicine
Nanotechnology and Prosthetics
Summary of Nanoengineered Restorative Tissue Engineering and Prosthetics
Diagnosis: Nanosensors in Diagnosis and Medical Monitoring
Sensors: Nanotechnology-Driven Advances in Diagnostic and Monitoring Technology
Technologies for Genomics and Proteomics
Applied Genomics and Proteomics: From Personalized Medicine to Global Epidemiology
Real-Time and In Vivo Medical Monitoring
Part III: Future Directions and Transformations
Thesis, Antithesis, Synthesis: Integrated Biomolecular Nanoscience
Maturation of Medical Nanotechnologies
Continued Impacts of Nanotechnology—Driven Capabilities
Nanotechnologies in Translation from Research
Indirect Impacts of Nanotechnology-Enabled Systems on Practice
Translation of Medical Nanotechnologies into Clinical Practice
Challenging Boundaries: Life and Material, Self and Environment
Nanotechnology and Medicine: A Powerful Confluence
Historical Origins of Medical Traditions
Knowledge of the Genome
Replacement Parts for the Body
Augmentation of Human Characteristics and Abilities
Extension of Life
Issues with Transplanted Cells for Regeneration
Medicalization of Normal Conditions
Other Boundaries Yet More Weird
Sustainability and Future Choices for Societies
Nanotechnology and Medicine as a Socioeconomic Activity
Questions of Change
Index
Biography
Tibbals, Harry F.
"Given that nanomedicine involves the application of fields as diverse as quantum physics, materials science, organic chemistry, molecular biology, semiconductor electronics, microfabrication, and mathematics, one might imagine that finding a good introductory presentation on this topic would be impossible. Fortunately, Tibbals’ book is up to the challenge. ... As befits an introductory book, the presentation is more comprehensive than deep and should be readily accessible to both the patient physician and the intelligent layman. ... However, each chapter contains a particularly rich selection of references for those readers interested in pursuing a particular topic in detail. ... In conclusion, this book provides a well-written, very well-referenced, modestly illustrated, and clinically focused evaluation of the current state of nanomedicine and its future prospects. Highly recommended."
--D. John Doyle, MD, Ph.D, Department of Anaesthesiology, Cleveland Clinic, Ohio, USA, Anesthesia & Analgesia, November 2013
