1st Edition
Reactive Oxygen Species in Biology and Human Health
Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress.
Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders.
The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens.
Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.
INTRODUCTION, DETECTION, AND PRODUCTION OF ROS
Introduction to Reactive Oxygen Species: Emphasizing Their Importance in the Male Reproductive System
Bongekile Skosana, Ibukun P. Oyeyipo, and Stefan S. Du Plessis
Detection of Reactive Oxygen Species
Oluwasesan Adegoke and Patricia B.C. Forbes
Ultraviolet Light, Chromophores, Reactive Oxygen Species, and Human Health
Shamim I. Ahmad
Ultraviolet A Radiation and ROS: Observations from Studies with Bacteria
Abraham Eisenstark and James Hoerter
ROS and Phenolic Compounds
Mario C. Foti and Riccardo Amorati
Lipoprotein-Associated Oxidative Stress
Ngoc-Anh Le
IMPORTANCE OF ACCUMULATION OF IRON IN THE BRAIN
Role of Oxidative Damage in Neurodegeneration with Brain Iron Accumulation Disorders
Vincenzo Lupo, Alejandra Darling, Cristina Tello, Belén Pérez-Duenas, and Carmen Espinós
NEURODEGENERATIVE DISEASES CAUSED BY ROS
Reactive Oxygen Species in Amyotrophic Lateral Sclerosis
Finley J. Allgaier and J. Jefferson P. Perry
Alzheimer’s Disease, Oxidative Stress, and Neuroprotective Approaches
Anami Ahuja, Kapil Dev, and Pankaj K. Tyagi
Oxidative Stress and Mitochondrial Dysfunction in Huntington’s and Other Neurodegenerative Diseases
Abhishek Chandra and Ashu Johri
Free Radicals, Oxidative Stress, and Epilepsy
Jaroslava Folbergrová
Oxidative Stress and Neuropsychiatric Disorders in the Life Spectrum
Akihiko Nunomura, Toshio Tamaoki, Nobutaka Motohashi, Hyoung-gon Lee, Xiongwei Zhu, and George Perry
Reactive Oxygen Species and Antioxidant Therapies for Multiple Sclerosis Treatment
Elzbieta Miller, Dominika Ksiazek-Winiarek, Tomasz Wlodarczyk, and Andrzej Glabinski
AUTOIMMUNE DISEASES CAUSED BY ROS
Pulmonary Oxidant-Antioxidant Dysregulation in Asthma
Ahmed Nadeem, Ahmed M. El-Sherbeeny, Mohammed M. Al-Harbi, and Sheikh F. Ahmad
Smoking and ROS: Catalyst for Autoimmune Liver Diseases
Tanima Bose
CANCERS INDUCED BY ROS
Inflammation and Lung Cancer: Oxidative Stress, ROS, and DNA Damage
Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo, and Rui Medeiros
ROS and Breast Cancer
Lenora Ann Pluchino and Hwa-Chain Robert Wang
Reactive Oxygen Species and Redox Signaling in Breast Cancer
Carolina Panis, Bruno Ricardo Barreto Pires, Ana Carolina de Andrade, Mateus Batista Silva, and Vanessa Jacob Victorino
Reactive Oxygen Species in Melanoma Etiology
Feng Liu-Smith
CARDIOVASCULAR DISEASES INDUCED BY ROS
Reactive Oxygen Species, Oxidative Stress, and Cardiovascular Disease
Eric L. Johnson
Reactive Oxygen Species in the Cardiovascular System
Hiroaki Shimokawa and Kimio Satoh
Reactive Oxygen Species, Antioxidants, Inflammation, and Cardiovascular Disease
Harald Mangge and Johanna M. Gostner
Carotenoids, ROS, and Cardiovascular Health
Maria Alessandra Gammone
OTHER UNCOMMON DISEASES INDUCED BY OXIDATIVE STRESS
Oxidative Stress and Sickle Cell Disease
Danilo Grünig Humberto da Silva, Edis Belini Junior, Claudia Regina Bonini-Domingos, and Eduardo Alves de Almeida
Oxidative Stress in Nonalcoholic Steatohepatitis
Akinobu Takaki, Daisuke Uchida, and Kazuhide Yamamoto
Reactive Oxygen Species and Diabetic Retinopathy
Mohammad Shamsul Ola and Haseeb Ahsan
Reactive Oxygen Species: Physiology and Pathogenesis in Systemic Lupus Erythematosus
Ashish Aggrwal, Nidhi Mahajan, Mansoor Ali Syed, Bishnuhari Paudyal, Swapan K. Nath, and Dilip Shah
Oxidative Stress in Fibromyalgia Syndrome
Ghizal Fatima
Redox Mechanisms in Pulmonary Diseases
Li Zuo, Chia-Chen Chuang, and Tingyang Zhou
Pathological Effects of Elevated Reactive Oxygen Species on Sperm Function
Gulfam Ahmad and Ashok Agarwal
Reactive Oxygen Species and Male Fertility: The Physiological Role
Ibukun P. Oyeyipo, Bongekile Skosana, and Stefan S. Du Plessis
Impact of Oxidative Stress on DNA Damage in Human Spermatozoa
J.V. Villegas, P. Uribe, R. Boguen, and F. Treulen
Skin Aging, Reactive Oxygen Species, and Its Prevention
Vibha Rani
ROS and Ataxia Telangiectasia
Tetsuo Nakajima
Role of Oxidative Stress in RNA Virus-Induced Cell Death
Mohammad Latif Reshi and Jiann-Ruey Hong
Organophosphate-Induced Oxidative Stress and Neurotoxicity
Alan J. Hargreaves
Reactive Oxygen Species and Morphine Addiction
Zheng Qiusheng and Ma Jun
Exercise, Nitric Oxide, and ROS
Leonardo Y. Tanaka, Luiz Roberto G. Bechara, and Paulo R. Ramires
ROS and Epigenetics
Eric Hervouet, Jianhua Zhang, and Michaël Boyer-Guittaut
Biography
Shamim I. Ahmad, after earning his master’s degree in botany from Patna University, Bihar, India, and his PhD in molecular genetics from the University of Leicester, England, joined Nottingham Polytechnic as a grade 1 lecturer and was subsequently promoted to the senior lecturer post. Nottingham Polytechnic subsequently became Nottingham Trent University, where, after serving for about 35 years, he took early retirement, yet continued serving as a part-time senior lecturer. Dr. Ahmad is now spending much of his time producing/writing medical books. His present interests include DNA damage and repair, specifically by near-ultraviolet light.