1st Edition

Biomedical Microsystems

By Ellis Meng Copyright 2011
    408 Pages 306 B/W Illustrations
    by CRC Press

    Poised to dramatically impact human health, biomedical microsystems (bioMEMS) technologies incorporate various aspects from materials science, biology, chemistry, physics, medicine, and engineering. Reflecting the highly interdisciplinary nature of this area, Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications.

    Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering.

    For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages readers to begin to formulate their own ideas about the design of novel bioMEMS. A solutions manual is available for instructors who want to convert this reference to classroom use.

    Introduction
    Evolution of MEMS
    Applications of MEMS
    BioMEMS Applications
    MEMS Resources
    Text Goals and Organization
    Miniaturization and Scaling

    BioMEMS Materials
    Traditional MEMS and Microelectronic Materials
    Polymeric Materials for MEMS
    Biomaterials

    Microfabrication Methods and Processes for BioMEMS
    Introduction
    Microlithography
    Doping
    Micromachining
    Wafer Bonding, Assembly, and Packaging
    Surface Treatment
    Conversion Factors for Energy and Intensity Units
    Laboratory Exercises

    Microfluidics
    Introduction and Fluid Properties
    Concepts in Microfluidics
    Fluid-Transport Phenomena and Pumping
    Flow Control
    Laboratory Exercises

    Lab-on-a-Chip or Micro Total Analysis Systems
    Microanalytical Systems in Chemistry and Biology
    Sample Pretreatment
    Sample Introduction
    Separations

    Sensing and Detection Methods
    Sensing and Detection
    Sensor Characteristics
    Principles of Physical Sensing
    Biological and Chemical Detection Methods

    Applications to Cells, Nucleic Acids, and Proteins
    Cells
    Nucleic Acids
    Proteins

    Clinical Monitoring
    Flow Cytometry
    Microdialysis
    Catheter-Based Sensors
    Endoscopy
    Point of Care

    MEMS Implants and Bioelectric Interfaces
    Implantable MEMS
    Microelectrodes and Neural Probes
    Implantable Sensors
    Drug Delivery
    Tissue Engineering

    Index

    Problems and References appear at the end of each chapter.

    Biography

    Ellis Meng is an associate professor in the Department of Biomedical Engineering and the Ming Hsieh Department of Electrical Engineering at the University of Southern California. As an assistant professor, she held the Viterbi Early Career Chair. One of Technology Review’s 2009 Young Innovators Under 35, Dr. Meng has been a recipient of the NSF CAREER Award and the Wallace H. Coulter Foundation Early Career Translational Research Award.