3rd Edition
New Therapeutic Agents in Thrombosis and Thrombolysis
As the number of patients with thrombosis and thrombolysis increases, there is a critical need for clinicians to learn the latest scientific discoveries and treatment options. This timely Third Edition is a comprehensive text for cardiologists, hematologists, and pharmacologists in need of a resource on current agent development technology for treating cardiovascular and thromboembolic diseases.
New to the Third Edition:
- a thorough examination of all the agents involved in treating thrombosis
- chapters on biomarkers, testing, and pharmacogenomics
- key topics, including new targets for antithrombotics, the development of novel classes of platelet inhibitors, new thrombolytic therapies, and evolving clinical uses of thrombolytics for ischemic stroke and venous thrombosis
- the hemostatic and thrombotic pathways
OVERVIEW OF THE INVESTIGATION AND REGULATION AND THROMBOSIS
Jane EFreedman
Overview of Hemostasis and Fibrinolysis, Andrew ISchafer
Overview of Platelet-Dependent Thrombosis, Jane EFreedman, Price Blair, and Joseph Loscalzo
Design Issues in Clinical Trials of Thrombolytic and Antithrombotic Agents, Robert PGiugliano
Pharmacogenomics and Warfarin Anticoagulation, Melkon Hacobian and Samuel ZGoldhaber
Pharmacogenomics of Platelet Inhibitors, Srikanth Nagalla, Suzanne MLeal, and Paul FBray
The Effects of Antiplatelet, Antithrombotic, and Thrombolytic Agents on Inflammation and Circulating Inflammatory Biomarkers, Erdal Cavusoglu
The Role of Platelet Function Testing in the Development of Platelet Inhibitors, Alan DMichelson
The Role of Proteomics and Transcriptomics in the Development of Antithrombotics, Lisa Senzel, Dmitri VGnatenko, and Wadie FBahou
NEW HEPARINS, THROMBIN INHIBITORS, AND ANTITHROMBOTICS
Jeffrey IWeitz
Overview of New Anticoagulant Drugs, Nahid Qushmaq and Jeffrey IWeitz
Anticoagulants for the Treatment of Venous Thromboembolism, Sam Schulman
Anticoagulation in Acute Coronary Syndromes, Simon JMcRae and John WEikelboom
Anticoagulation in Pregnancy, Shannon MBates
Anticoagulants in Cancer, Edward NLibby and Agnes YLee
Anticoagulation in Children, Paul TMonagle and Anthony K.CChan
New Heparins: Synthetic Pentasaccharides, Pieter WKamphuisen and Harry RBüller
Treatment of Heparin-Induced Thrombocytopenia, Theodore EWarkentin
Emerging Links Between Thrombosis, Inflammation, and Angiogenesis: Key Role of Heparin and Low-Molecular-Weight Heparins, Shaker AMousa
Oral Direct Factor Xa Inhibitors, Alexander GGTurpie
Direct Thrombin Inhibitors, Menaka Pai and Mark ACrowther
Modulators of the Protein C Pathway, Charles TEsmon
Factor IXa Inhibitors, Richard CBecker, Mark Chan, Emily LHoward, Kristian CDBecker, and Christopher PRusconi
Contact-Activation Pathways as Targets for New Anticoagulants, David Gailani, Thomas Renne´, and Andras Gruber
NEW ANTIPLATELET AGENTS
Robert PGiugliano
Overview of Antiplatelet Therapy, Shaker AMousa, James TWillerson, and Robert PGiugliano
Markers of Platelet Function, Udaya STantry and Paul AGurbel
Intravenous Glycoprotein IIb/IIIa Antagonists, Jason NKatz and Robert AHarrington
Inhibitors of Platelet Adhesion: VWF-GPb/IX and Collagen-GPVI
Inhibitors, Robert GSchaub
Three Generations of Thienopyridines: Ticlopidine, Clopidogrel, and Prasugrel, Stephen DWiviott and Elliott MAntman
Direct PYAntagonists, Marco Cattaneo
Nitric Oxide Donors as Platelet Inhibitors, Lina Badimon and Gemma Vilahur
The Interrelationship of Thrombin and Platelets—The Protease-Activated Receptor-, Rohit Bhatheja and David JMoliterno
Other Antiplatelet Agents, Catherine McGorrian and Sonia SAnand
The Combination of Anticoagulants and Platelet Inhibitors Postcoronary Stent Implantation, Hussam Hamdalla and Steven RSteinhubl
NEW THROMBOLYTIC AGENTS AND INDICATIONS
HRoger Lijnen
Overview of Established and New Thrombolytics, HRoger Lijnen
Thrombolysis of Deep Vein Thrombosis, Peter Verhamme, Raymond Verhaeghe, and Geert Maleux
Thrombolysis for Acute Pulmonary Embolism, Gregory Piazza and Samuel ZGoldhaber
Acute Thrombolysis in Ischemic Cerebrovascular Disease, Gregory Jdel Zoppo
Fibrinolysis for Acute Myocardial Infarction, Cheuk-Kit Wong and Harvey DWhite
Epilogue: The Evolution of Therapeutic Management of Thrombotic and Cardiovascular Disease, Jane EFreedman and Joseph Loscalzo
Index
Biography
Jane E. Freedman, Joseph Loscalzo
"…Full of important information… is a definite addition to the medical literature." —Doody’s Reviews (for the Second Edition)
