DNA Repair and Cancer

From Bench to Clinic

Edited by Srinivasan Madhusudan, David M. Wilson III

© 2013 – CRC Press

718 pages | 18 Color Illus. | 56 B/W Illus.

Purchasing Options:
Hardback: 9781466577435
pub: 2013-01-21
US Dollars$240.00
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About the Book

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

Table of Contents

Overview of DNA Repair Pathways

Longevity Assurance by Genome Maintenance

Genome Instability of Cancer: Biological Predictions and Clinical Implications

Radiation Induced DNA Damage, Repair and Therapeutics

Chemotherapeutic Alkylating Agents in Cancer Treatment

O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy

DNA Mismatch Repair: It’s Role in Human Carcinogenesis and as a Predictive and/or Prognostic Biomarker for Cancer Therapy

DNA Base Excision Repair Therapeutics: Summary of Targets with a Focus on APE1

Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer Susceptibility

Fanconi Anemia, Interstrand Cross-link Repair and Cancer

Functions of Translesion DNA Polymerases: Implications for Cancer Risk and Opportunities as Therapeutic Targets

p53 in DNA Damage, Repair and Cancer Therapeutics

ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation in Cancer Therapy

The BRCA1-BRCA2 Pathway of Homologous Recombination and the Opportunity for Synthetic Lethal Approaches to Cancer Therapy

PARP and PARP Inhibitor Therapeutics

Tumor Genetics and Personalized Medicine

The Tumor Microenvironment and DNA Repair: Implications for Cancer Progression and Treatment

Early Phase Clinical Trials using DNA Repair Inhibitors: Lessons Learnt

Subject Categories

BISAC Subject Codes/Headings:
MED062000
MEDICAL / Oncology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology