© 2016 – Chapman and Hall/CRC
504 pages | 77 B/W Illus.
This self-contained book focuses on mathematical models related to cancer growth and treatment. It presents the medical and biological background of the diseases, specific issues to be modeled, and existing methods and their limitations. The book introduces mathematical and programming tools, along with analytical and numerical studies of the models. The authors also develop new mathematical tools and look to future improvements on dynamical models. The text provides many classroom-tested exercises and projects at the end of most chapters.
Chapter 1 provides a brief introduction to the general theory of medicine and how mathematics can be essential in its understanding. Chapter 2 introduces readers to some well-known, practical, and insightful mathematical models of avascular tumor growth and mathematically tractable treatment models based on ordinary differential equations. Chapter 3 continues the topic of avascular tumor growth in the context of partial differential equation (PDE) models by incorporating the spatial structure while Chapter 4 expands the topic of avascular tumor growth in a PDE context by incorporating physiological structure, such as cell size. Chapter 5 focuses on the recent active multi-scale modeling efforts on prostate cancer growth and treatment dynamics. Chapter 6 exposes readers to more mechanistically formulated models, including cell quota-based population growth models with applications to real tumors and validation using clinical data. The remaining chapters present abundant additional historical, biological, and medical background materials for advanced and specific treatment modeling efforts.
Although this book is useful to professionals in various fields, it is designed as a textbook for both graduate and upper-division undergraduate courses in mathematical oncology. The text can be used in a variety of ways, allowing instructors to emphasize specific topics relevant to clinical cancer biology and treatment. A sample single semester undergraduate-level course may cover the first three chapters plus Chapter 5. A more ambitious graduate-level course may cover the first 6 chapters plus selected readings from later material and cited literature. A full year sequence on mathematical oncology may cover most of the chapters.
"This is a very interesting and well-written book … The book chapters cover a wide range of topics related to cancer dynamics and treatments focusing on chemotherapy and radiotherapy as the most traditional and commonly used procedures. Various types of cancer are discussed from the point of view of their growth, progression, and treatment with a special emphasis on prostate cancer, an area where the authors have made significant research contributions. All the topics covered are presented in an easily accessible way, starting with the most elementary introduction to the problems and leading all the way to the discussion of new trends and challenges concerning the subject. In all presentations, a nice balance between mathematics and biology is kept, a very welcome feature facilitated by the mixed background of the authors.
The book is suitable as a textbook for both undergraduate and graduate courses … . The material is presented in an interesting, sometimes even intriguing manner, and it is supported with valuable exercises, projects, and open questions allowing for hands-on experiences. Students can learn a fair amount of both biology and mathematics from this text and see how these two disciplines come together to shed light on to understanding one of the biggest problems and challenges of our century: cancer."
—Professor Urszula Ledzewicz, Southern Illinois University, Edwardsville, USA, and Lodz University of Technology, Poland
Introduction to Theory in Medicine
Introduction to Cancer Modeling
Spatially Structured Tumor Growth
Physiologically Structured Tumor Growth
Prostate Cancer: PSA, AR, and ADT Dynamics
Resource Competition and Cell Quota in Cancer Models
Natural History of Clinical Cancer
Evolutionary Ecology of Cancer
Models of Chemotherapy
Major Anti-Cancer Chemotherapies
Epilogue: Toward a Quantitative Theory of Oncology