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This special issue reviews the literature on the neuropsychological sequelae and CNS complications of pediatric sickle cell disease while also emphasizing the integration of neuro psychology which is critical for interfacing with these patients. Executive dysfunction related to frontal infarcts, neurocognitive benefit of hydroxyurea, and the influence of illness-related and psychosocial factors on neuropsychological outcomes are described. A controlled replication study of peer relationships and emotional well-being is equally informative about statistical considerations regarding small sample sizes and low-incidence illnesses. The much anticipated adolescent version of the Sickle Cell Self-Efficacy Scale is reported by the test authors.
L. Berkelhammer, Introduction to the Special Issue on Sickle Cell Disease. W. Wang, Central Nervous System Complications of Sickle Cell Disease in Children - An Overview. L. Berkelhammer, A. Williamson, S. Sanford, C. Dirksen, W. Sharp, A. Margulies, R. Prengler, Neurocognitive Sequelae of Pediatric Sickle Cell Disease: A Review of the Literature. S. Christ, A. Moinuddin, R. McKinstry, M. DeBaun, D. White, Inhibitory Control in Children with Frontal Infarcts Related to Sickle Cell Disease.E. Puffer, J. Schatz, C. Roberts, The Association of Oral Hydroxyurea Therapy with Improved Cognitive Functioning in Sickle Cell Disease. R. Tarazi, M. Grant, E. Ely, L. Barakat, Neuropsychological functioning in preschool-age children with sickle cell disease: The role of illness-related and psychosocial factors. R. Noll, J. Reiter-Purtill, K. Vannatta, C. Gerhardt, A. Short, Peer Relationships and Emotional Well-Being of Children with Sickle Cell Disease: A Controlled Replication. O. Clay, J. Telfair, Evaluation of a Disease-Specific Self-Efficacy Instrument in Adolescents with Sickle Cell Disease and its Relationship to Adjustment.