Clinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies. It provides the clinical researcher with a powerful evaluation paradigm, as well as…
Paperback – 2019-03-22
Chapman and Hall/CRC
Chapman & Hall/CRC Biostatistics Series
Praise for the first edition: "Given the author’s years of experience as a statistician and as a founder of the first DMC in pharmaceutical industry trials, I highly recommend this book—not only for experts because of its cogent and organized presentation, but more importantly for young…
Paperback – 2019-03-22
Chapman and Hall/CRC
Chapman & Hall/CRC Biostatistics Series
Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S.…
Paperback – 2019-03-22
Chapman and Hall/CRC
Chapman & Hall/CRC Biostatistics Series
The aim of this unique volume is to help medical researchers design clinical trials to improve survival, remission duration, or time to recurrence of disease. Written in a user-friendly step-by-step format, this work enables the researcher-with no background in statistics-to determine sample size…
Paperback – 2019-01-30
CRC Press
CRC Press Revivals
Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or "noninformativeness" of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with…
Paperback – 2018-09-10
Chapman and Hall/CRC
Chapman & Hall/CRC Biostatistics Series
Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been…
Paperback – 2017-09-12
Chapman and Hall/CRC
Advancing the development, validation, and use of patient-reported outcome (PRO) measures, Patient-Reported Outcomes: Measurement, Implementation and Interpretation helps readers develop and enrich their understanding of PRO methodology, particularly from a quantitative perspective. Designed for…
Paperback – 2016-11-16
Chapman and Hall/CRC
Chapman & Hall/CRC Biostatistics Series
Get Up to Speed on Many Types of Adaptive Designs Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second…
Paperback – 2016-10-14
Chapman and Hall/CRC
Chapman & Hall/CRC Biostatistics Series