This special issue is devoted to the cancerchemopreventive effects of the trace element selenium. Although epidemiological and animal model studies have contributed enormously to this field, the clinical trial headed by the late Dr. Larry Clark brought to light the very real possibility that selenium compounds may serve as protective agents in populations at risk for prostate, colon, and lung cancers. For this reason, experts from various disciplines have been brought together to address the current state of the knowledge of the role of selenium as an anticancer agent. It is hoped that by bringing these various approaches together in one place, the research community, both graduate students and established investigators, can better grasp the complex nature of this field. The papers in this issue cover the entire spectrum of cancer research, ranging from clinical trials to animal model studies and molecular biology.
Volume 40, Number 1, 2001. Contents: L.A. Cohen, Introduction. K. El-Bayoumy, Overview: The Late Larry C. Clark Showed the Bright Side of the Moon Element (Selenium) in a Clinical Cancer Prevention Trial. G.F. Combs, Jr., Impact of Selenium and Cancer-Prevention Findings on the Nutrition-Health Paradigm. D. Medina, H. Thompson, H. Ganther, C. Ip, Se-Methylselenocysteine: A New Compound for Chemoprevention of Breast Cancer. K. El-Bayoumy, C.V. Rao, B.S. Reddy, Multiorgan Sensitivity to Anticarcinogenesis by the Organoselenium 1, 4-Phenylenebis (Methylene) Selenocyanate. B.W. Youn, E.S. Fiala, O.S. Sohn, Mechanisms of Organoselenium Compounds in Chemoprevention: Effects on Transcription Factor-DNA Binding. J.E. Spallholz, B.J. Shriver, T.W. Reid, Dimethyldiselenide and Methylseleninic Acid Generate Superoxide in an In Vitro Chemiluminescence Assay in the Presence of Glutathione: Implications for the Anticarcinogenic Activity of L-Selenomethionine and L-Se-Methylselenocysteine. J. Fleming, A. Ghose, P.R. Harrison, Molecular Mechanisms of Cancer Prevention by Selenium Compounds. Y.S. Kim, J. Milner, Molecular Targets for Selenium in Cancer Prevention. R. Gopalakrishna, U. Gundimeda, Protein Kinase C as a Molecular Target for Cancer Prevention by Selenocompounds. J. Lu, C. Jiang, Antiangiogenic Activity of Selenium in Cancer Chemoprevention: Metabolite-Specific Effects. J.R. Marshall, Larry Clark's Legacy: Randomized Controlled, Selenium-Based Prostate Cancer Chemoprevention Trials.