This up-to-date, comprehensive toxicology handbook is devoted to the effects of environmental pollution on fish. Fish species represent nearly half of all vertebrates and have become important sentinels for environmental contamination and model organisms for understanding adverse outcomes from exposures. This new edition is written by recognized experts, and it highlights the significant research progress in fish toxicology that has resulted from rapid technological developments in analytical, biochemical, and genomic sciences. The book:
- Discusses fundamental topics such as toxicokinetics in fishes, processes governing biotransformation within these organisms, and reactive oxygen species and oxidative stress
- Explains key target organ systems for chemical impacts in fish, such as the nervous and immune systems, and how fishes can develop resistance to chemical toxicity
- Covers multi-transgenerational effects on fishes, epigenetics, proteomics and metabolomics, and adverse outcome pathways
Replacing the case studies in the first edition, this update delves into the impacts of microplastics, pharmaceuticals, and oil spills in dedicated final chapters. With nearly 200 illustrations and tables, this comprehensive reference work presents concepts in a way that is useful for both novices to and experts in the field of fish toxicology.
1 Introduction
Neelakanteswar Aluru and Kristine L. Willett
2 Toxicokinetics in Fishes
John W. Nichols, Jon A. Arnot, and Mace G. Barron
3 Biotransformation in Fishes
Daniel Schlenk, Jed Goldstone, Margaret O. James, and Peter van den Hurk
4 Reactive Oxygen Species and Oxidative Stress
Alicia R. Timme-Laragy, Richard T. Di Giulio, and Joel N. Meyer
5 Toxic Responses of the Fish Nervous System
Michael J Carvan III and Steven P. Bradbury
6 The Immune System of Fish: A Target Organ of Toxicity
Charlie Rice, Judy Zelikoff, and Helmet Segner
7 Toxicity Resistance: Physiological Acclimations and Evolutionary Adaptations to Chemical Stress
Diane E. Nacci, Bryan W. Clark, and Andrew Whitehead
8 Endocrine Disruption in Teleosts: Mechanisms of Endocrine Toxicity and Experimental Approaches
Megan E. Solan and Ramon Lavado
9 Multi- and Transgenerational Health Effects of Exposure to Toxicants in Fish
Tracie R. Baker and Danielle Meyer
10 Epigenetics
Neelakanteswar Aluru and Kristine L. Willett
11 Proteomics and Metabolomics
Christopher J. Martyniuk and Nancy D. Denslow
12 Adverse Outcome Pathways
Daniel L. Villeneuve and Gerald T. Ankley
13 The Potential for Toxicity to Fishes from Micro and Nanoplastics, and their Additives
Susanne M. Brander, Azora König, Bethanie Almroth Carney, and Leah Thornton Hampton
14 Effects of Pharmaceuticals
Karl Fent, Nadja R. Brun, Kun Zhang, and Yanbin Zhao
15 Oil Spills
Fernando Galvez
Biography
Kristine L. Willett, PhD is Chair of the Department of BioMolecular Sciences in the School of Pharmacy at the University of Mississippi (UM). A professor of Pharmacology and Environmental Toxicology, she has taught both graduate and undergraduate courses in toxicology and environmental toxicology at UM since 2000. Dr. Willett earned her BA in Chemistry at the University of North Carolina and a PhD in Toxicology from Texas A&M University. She was a Dreyfus postdoctoral fellow in environmental chemistry at Indiana University followed by an RJR Leon Golberg postdoctoral fellow in toxicology at Duke University. Dr. Willett’s research has been funded over the years by NIDA, NIEHS, NOAA, USGS, and the Army Corps of Engineers and resulted in 80+ manuscripts and book chapters. Throughout her career she has led research projects which were designed to fundamentally understand the molecular mechanisms underlying toxicity and/or shed light on the potential adverse outcomes due to relevant anthropogenic contamination. Her lab has studied the developmental, reproductive and multigenerational impacts of nanosilver, cannabinoid and benzo[a]pyrene exposures using fish models. She also studies consequences of environmental stressors on oysters. She serves as a Deputy Editor of Toxicological Sciences. She has been elected to leadership positions in the Society of Environmental Toxicology and Chemistry and the Society of Toxicology (SOT). SOT and American Association of Colleges of Pharmacy. (AACP) have also recognized her with undergraduate and graduate educator awards, respectively. At UM, she earned the 2022 Research and Distinguished Achievement Award and the 2017 Faculty Achievement Award.
Neelakanteswar Aluru, PhD is an Associate Scientist in the Biology Department at Woods Hole Oceanographic Institution (WHOI). Dr. Aluru earned his Bachelor of Fisheries Science at the Orissa University of Agriculture and Technology in Berhampur, India, followed by a Master of Fisheries Science (Aquaculture) from Kerala Agricultural University Cochin, India. He earned a Master of Science from the College of Fishery Science, University of Tromsø, Norway. He received his PhD in Biology from the University of Waterloo, Ontario, Canada where he studied influence of persistent organic pollutants on the endocrine stress axis in rainbow trout. He has held postdoctoral research appointments at the University of Guelph, Ontario Canada and at WHOI. Since 2012, he has been conducting research as an independent scientist at WHOI. His research interests are mainly focused in the field of environmental epigenetics, particularly the epigenetic processes involved in determining phenotypic (and/or developmental) plasticity in response to environmental cues/stressor exposures. His laboratory uses a variety of vertebrate and invertebrate model systems and employs a number of different molecular biology methods –gene-specific to high-throughput sequencing to study epigenetic modes of action. He is part of the Woods Hole Center for Oceans and Human Health.
"Provides a useful resource for the regulatory toxicologist… well-presented and concise book worthy of a position on the bookshelf of all fish toxicologists."
—Jonathan Burke, Covance Laboratories Ltd, UK, in the British Toxicology Society Newsletter
