50 Landmark Papers every Neurosurgeon Should Know

Section One - Tumour

1 - Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO

Expert commentary by Ryan Gensler, Melanie Alfonzo Horowitz and Chetan Bettegowda

2 - MGMT gene silencing and benefit from temozolomide in glioblastoma

Monika E. Hegi, Ph.D., Annie-Claire Diserens, M.Sc., Thierry Gorlia, M.Sc., Marie-France Hamou, Nicolas de Tribolet, M.D., Michael Weller, M.D., Johan M. Kros, M.D., Johannes A. Hainfellner, M.D., Warren Mason, M.D., Luigi Mariani, M.D., Jacoline E.C. Bromberg, M.D., Peter Hau, M.D., René O. Mirimanoff, M.D., J. Gregory Cairncross, M.D., Robert C. Janzer, M.D., and Roger Stupp, M.D.

Expert commentary by Melanie Alfonzo Horowitz, Ryan Gensler and Chetan Bettegowda

3 - Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial

Walter Stummer, Uwe Pichlmeier, Thomas Meinel, Otmar Dieter Wiestler, Friedhelm Zanella, Hans-Jürgen Reulen, for the ALA-Glioma Study Group

Expert commentary by Walter Stummer

4 - A randomized trial of surgery in the treatment of single metastases to the brain

Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS, Young B

Expert commentary by Jose Lavrador, Francesco Vergani and Keyoumars Ashkan

5 - Prognostic factors for survival in adult patients with cerebral low-grade glioma

Francesco Pignatti, Martin van den Bent, Desmond Curran, Channa Debruyne, Richard Sylvest-er, Patrick Therasse, Denes Afra, Philippe Cornu, Michel Bolla, Charles Vecht, Abul B M F Karim

Expert commentary by Francesco Vergani, Jose Lavrador and Keyoumars Ashkan

6 - Long-term outcomes after supratotal resection of diffuse low-grade gliomas: a consecutive series with 11-year follow-up

Hugues Duffau

Expert commentary by Piiamaria S. Virtanen, Chiara A. Flores and Angela M. Richardson

7 - The recurrence of intracranial meningiomas after surgical treatment

Simpson D

Expert commentary by Abdurrahman I. Islim and Omar N. Pathmanaban

8 - Phase I/II study of resection and intraoperative cesium-131 radioisotope brachytherapy in patients with newly diagnosed brain metastases

Wernicke AG, Yondorf MZ, Peng L, Trichter S, Nedialkova L, Sabbas A, Kulidzhanov F, Parashar B, Nori D, Clifford Chao KS, Christos P, Kovanlikaya I, Pannullo S, Boockvar JA, Stieg PE, Schwartz TH

Expert commentary by Ken Virgin & Jignesh Tailor

9 - Natural history of asymptomatic colloid cysts of the third ventricle

Bruce E. Pollock, M.D.; John Huston, III, M.D

Expert commentary by Bruce E. Pollock

Section Two - Vascular

10 - Surgical Risk as Related to Time of Intervention in the Repair of Intracranial Aneurysms

Willliam E. Hunt, M.D., Robert M. Hess, M.D

Expert commentary by Matthew Tobin and Brad Bohnstedt

11 - International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial

Molyneux A, Kerr R, Stratton I, Sandercock P, Clarke M, Shrimpton J, Holman R

Expert commentary by Richard Kerr

12 - International Study of Unruptured Intracranial Aneurysms Investigators. (ISUIA2) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment.

Wiebers DO et al

Expert commentary by Daniel C. Walsh

13 - Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial

Pickard JD, Murray GD, Illingworth R, Shaw MD, Teasdale GM, Foy PM, Humphrey PR, Lang DA, Nelson R, Richards P, et al.

Expert commentary by Ramez Wadie Kirollos

14 - A proposed grading system for arteriovenous malformations

Robert F. Spetzler

Expert commentary by Robert F Spetzler

15 - Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials

Katayoun Vahedi, Jeannette Hofmeijer, Eric Juettler, Eric Vicaut, Bernard George, Ale Algra, G Johan Amelink, Peter Schmiedeck, Stefan Schwab, Peter M Rothwell, Marie-Germaine Bousser, H Bart van der Worp, Werner Hacke, for the DECIMAL, DESTINY, and HAMLET investigators

Expert commentary by Fezaan A Kazi and Rabia Qaiser

16 - Benefit of Carotid Endarterectomy in Patients with Symptomatic Moderate or Severe Stenosis. North American Symptomatic Carotid Endarterectomy Trial (NASCET)

Henry J.M. Barnett, M.D., D. Wayne Taylor, M.A., Michael Eliasziw, Ph.D., Allan J. Fox, M.D., Gary G. Ferguson, M.D., R. Brian Haynes, M.D., Richard N. Rankin, M.D., G. Patrick Clagett, M.D., Vladimir C. Hachinski, M.D., David L. Sackett, M.D., Kevin E. Thorpe, M.Math., Heather E. Meldrum, B.A., and J. David Spence, M.D.

Expert commentary by Alice L Hung and Judy Huang

17 - Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH)

ENRICH investigators, Pradilla G, Ratcliff JJ, Hall AJ, Saville BR, Allen JW, Paulon G, McGlothlin A, Lewis RJ, Fitzgerald M, Caveney AF, Li XT, Bain M, Gomes J, Jankowitz B, Zenonos G, Molyneaux BJ, Davies J, Siddiqui A, Chicoine MR, Keyrouz SG, Grossberg JA, Shah MV, Singh R, Bohnstedt BN, Frankel M, Wright DW, Barrow DL

Expert commentary by Aditya Kondajji and Mark Bain

Section Three - Paediatrics

18 - Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus. 

Drake JM, Kestle JR, Milner R, Cinalli G, Boop F, Piatt J Jr, Haines S, Schiff SJ, Cochrane DD, Steinbok P, MacNeil N

Expert commentary by Eisha Christian

19 - Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus

Kulkarni AV, Drake JM, Mallucci CL, Sgouros S, Roth J, Constantini S

Expert commentary by Armaan K Malhotra and Abhaya V Kulkarni

20 - Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation

Mallucci CL, Jenkinson MD, Conroy EJ, Hartley JC, Brown M, Dalton J, Kearns T, Moitt T, Griffiths MJ, Culeddu G, Solomon T, Hughes D, Gamble C, for the BASICS Study collaborators

Expert commentary by Michael D. Jenkinson and Conor L. Mallucci

21 - A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele (MOMS trial)

N. Scott Adzick, M.D., Elizabeth A. Thom, Ph.D., Catherine Y. Spong, M.D., John W. Brock, III, M.D., Pamela K. Burrows, M.S., Mark P. Johnson, M.D., Lori J. Howell, R.N., M.S., Jody A. Farrell, R.N., M.S.N., Mary E. Dabrowiak, R.N., M.S.N., Leslie N. Sutton, M.D., Nalin Gupta, M.D., Ph.D., Noel B. Tulipan, M.D., Mary E. D'Alton, M.D., and Diana L. Farmer

Expert commentary by Kholoud Arab and Hiba J. Mustafa

22 - Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants less than 1,500 gm.

Papile LA, Burstein J, Burstein R, Koffler H

Expert commentary by Lu-Ann Papile

23 - Intrinsic brain-stem tumors of childhood:  surgical indications

Fred Epstein and E. Larry McCleary

Expert commentary by Alan R. Cohen

24 - Molecular subgroups of medulloblastoma: the current consensus

Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM

Expert commentary by Trenton A. Line and Jignesh Tailor

25 - Pial Synangiosis for Moyamoya Syndrome in Children

P. David Adelson, R. Michael Scott

Expert commentary by Edward R. Smith

26 - Hypothermia Therapy after Traumatic Brain Injury in Children

Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Fergusson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW

Expert commentary by Anoop Chinthala and Gordan Mao

Section Four - Functional/Epilepsy

27 - The first clinical trial to establish deep brain stimulation of the subthalamic nucleus as an evidence-based treatment for Parkinson’s disease

Günther Deuschl et al., for the German Parkinson Study Group, Neurostimulation Section

Expert commentary by Günther Deuschl

28 - The Long-term Outcome of Microvascular Decompression for Trigeminal Neuralgia

Fred G. Barker II, M.D., Peter J. Jannetta, M.D., D. Sc., David J. Bissonette, P.A.-C., Mark V. Larkins, M,D., Hae Dong Jho, M.D., Ph. D.

Expert commentary by Josue Ordaz, Joao Paulo Almeida and Mitesh Shah

29 - A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy

Samuel Wiebe, M.D., Warren T. Blume, M.D., John P. Girvin, M.D., Ph.D., and Michael Eliasziw, Ph.D., for the Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group

Expert commentary by Tom Larrew and Jason Chu

30 - Early Identification of Refractory Epilepsy

Patrick Kwan, M.D., and Martin J. Brodie, M.D

Expert commentary by Rob Blake

31 - Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect on seizures

E. Ben-Menachem, R. Mañon-Espaillat, R. Ristanovic, B. J. Wilder, H. Stefan, W. Mirza, W. B. Tarver, J. F. Wernicke, and First International Vagus Nerve Stimulation Study Group

Expert commentary by Jason Chu and Tom Larrew

32 - Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance

Wada J, Rasmussen T

Expert commentary by Sydney McQueen and George Ibrahim

Section Five - Head Trauma

33 - Assessment of coma and impaired consciousness. A practical scale

Teasdale G, Jennett B

Expert commentary by Paul Brennan

34 - Traumatic Acute Subdural Hematoma:  Major Mortality Reduction in Comatose Patients Treated within Four Hours

John M. Seelig M.D., Donald P. Becker M.D., J. Douglas Miller M.D. Ph.D,  Richard P. Greenberg M.D., John D. Ward M.D., and Sung C Choi PhD.

Expert commentary by Laurie L. Ackerman

35 - Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial

Santarius T, Kirkpatrick PJ, Ganesan D, et al

Expert commentary by BM Davies and T Santarius

36 - Significance of intracranial hypertension in severe head injury

Miller JD, Becker DP, Ward JD, Sullivan HG, Adams WE, Rosner MJ.

Expert commentary by Allie Heineman, Kyle Mcgrath and Laura B Ngwenya

37 - A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures

Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR

Expert commentary by Derryl Miller

38 - Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months.

Ian Roberts et al for the CRASH Trial Investigators

Expert commentary by Mark Wilson

39 - Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension (RESCUEicp trial).

Peter Hutchinson et al., RESCUEicp Trial Collaborators

Expert commentary by Angelos G Kolias and Peter J Hutchinson

40 - Surgical Management of Acute Epidural Hematomas

Bullock, M. R. et al.

Expert commentary by Shelly D. Timmons

Section Six - Spine Trauma

41 - Validity of a Set of Clinical Criteria to Rule Out Injury to the Cervical Spine in Patients with Blunt Trauma

Hoffman JR, Mower WR, Wolfson AB, Todd KH, Zucker MI

Expert commentary by Jae Hyun Kwon and Jamie Bradbury

42 - The subaxial cervical spine injury classification system: a novel approach to recognize the importance of morphology, neurology, and integrity of the disco-ligamentous complex

Vaccaro AR et al

Expert commentary by Alexander Vaccaro

43 - A new classification of thoracolumbar injuries: the importance of injury morphology, the integrity of the posterior ligamentous complex, and neurologic status

Alexander R Vaccaro, Ronald A Lehman Jr, R John Hurlbert, Paul A Anderson, Mitchel Harris, Rune Hedlund, James Harrop, Marcel Dvorak, Kirkham Wood, Michael G Fehlings, Charles Fisher, Steven C Zeiller, D Greg Anderson, Christopher M Bono, Gordon H Stock, Andrew K Brown, Timothy Kuklo, F C Oner

Expert commentary by Alexander Vaccaro

44 - A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Use of Methylprednisolone Sodium Succinate

Fehlings MG, Wilson JR, Tetreault LA, Aarabi B, Anderson P, Arnold PM, Brodke DS, Burns AS, Chiba K, Dettori JR, Furlan JC, Hawryluk G, Holly LT, Howley S, Jeji T, Kalsi-Ryan S, Kotter M, Kurpad S, Kwon BK, Marino RJ, Martin AR, Massicotte E, Merli G, Middleton JW, Nakashima H, Nagoshi N, Palmieri K, Skelly AC, Singh A, Tsai EC, Vaccaro A, Yee A, Harrop JS.

Expert commentary by Karlo M. Pedro and Michael G. Fehlings

Section Seven - Spine

45 - Effect of High-dose Dexamethasone in Carcinomatous Metastatic Spinal Cord Compression Treated with Radiotherapy: a Randomised Trial

Sørensen S, Helweg-Larsen S, Mouridsen H, Hansen HH

Expert commentary by Gordan Mao

46 - Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression Caused by Metastatic Cancer: A Randomised Trial

Roy A Patchell, Phillip A Tibbs, William F Regine, Richard Payne, Stephen Saris, Richard J Kryscio, Mohammed Mohiuddin, Byron Young

Expert commentary by Barnabas Obeng-Gyasi, Miracle Anokwute and Gordan Mao

47 - Surgical vs nonoperative treatment for lumbar disc herniation: the Spine Patient Outcomes Research Trial (SPORT): a randomized trial

Weinstein JN et al

Expert commentary by Thomas Noh, Dilon Putzler and Meng Huang

48 - Cauda Equina Syndrome Secondary to Lumbar Disc Herniation: A Meta-Analysis of Surgical Outcomes

Uri Michael Ahn, MD, Nicholas U. Ahn, MD, Jacob M. Buchowski, MS, Elizabeth S. Garrett, PhD, Ann N. Sieber, RN, MSN, and John P. Kostuik, MD

Expert commentary by Brandon Lane

49 - Surgical vs nonsurgical therapy for lumbar spinal stenosis

Weinstein JN, Tosteson TD, Lurie JD, Tosteson AN, Blood E, Hanscom B, Herkowitz H, Cammisa F, Albert T, Boden SD, Hilibrand A, Goldberg H, Berven S, An H

Expert commentary by Thomas Noh and Meng Huang

50 - The anterior approach for removal of ruptured cervical disks

Cloward, RB

Expert commentary by Abdulbaki Kozan and David Stockwell

Biography

Dr. Jignesh Tailor is currently Assistant Professor of Neurological Surgery at Indiana University School of Medicine and a Pediatric Neurosurgeon at Riley Hospital for Children. He received his medical degree from the University of Oxford Medical School and holds a PhD in Stem Cell Biology from the University of Cambridge. During neurosurgery training in London, Tailor received a highly competitive Wellcome Trust Post-Doctoral Research Award that allowed him to complete neurosurgery training at the Hospital for Sick Childrenin Toronto, Ontario while doing an enfolded Postdoctoral Research Fellowship at the University of Toronto. He completed fellowship training in Pediatric Neurosurgery at Johns Hopkins University Hospital in Baltimore in July 2021.