1st Edition
Chronic Obstructive Pulmonary Disease Exacerbations
Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.
Written by today’s top experts, Chronic Obstructive Pulmonary Disease Exacerbations:
- is formatted into separate sections covering imaging diagnosis and treatment, making this text practical and easy-to-use
- examines current and breakthrough pharmacologic and non-pharmacologic treatments
- includes COPD-causing exacerbations such as viral and bacterial infections
- discusses the negative environmental factors relating to COPD
PART I INTRODUCTION
Definitions and severity of COPD exacerbations: Stephen Rennard and Nancy Kline Leidy
Epidemiology of COPD exacerbations: David Mannino
Differential diagnosis of COPD exacerbations: Peter Calverley
PART II MECHANISMS AND PATHOPHYSIOLOGY
Symptom changes at exacerbations: Terry Seemungal
Airway pathology at exacerbations: Marina Saetta
Airway and systemic inflammatory markers at exacerbation: John Hurst
Physiological changes at exacerbations: Dennis O’Donnell and Chris Parker
Systemic consequences of COPD exacerbations: Emiel Wouters
Mechanisms of respiratory failure at exacerbation: Roberto Rodriguez Roisin
Role of respiratory viral infection at exacerbation: Wisia Wedzicha and Jennie Quint
Do airway bacteria cause COPD exacerbations: Sanjay Sethi
Interactions of airway pathogens and inflammatory processes: Alberto Papi
Role of co-morbidity at COPD exacerbations: Bill MacNee, John Maclay and David McAllister
Environmental causes of exacerbations: David Hui and Fanny Ko
Mechanisms and pathophysiological changes in alpha-1 AT deficiency exacerbations: Rob Stockley
Experimental models of COPD exacerbations: Jeff Curtis
Comparison of asthma and COPD exacerbations: Sebastian Johnston
PART III IMPACT OF EXACERBATIONS
Exacerbations and health status: Paul Jones
Risk factors for hospital admission: Judith Garcia Aymerich
Effect of exacerbations on disease progression and mortality: Gavin Donaldson
Health economic consequences of COPD exacerbations: Marc Miravitlles
PART IV MANAGEMENT OF THE ACUTE EXACERBATION
Use of bronchodilators and mucolytics at COPD exacerbations: Marc Decramer
Corticosteroids in the management of acute exacerbations: Denis Niewoehner
Antibiotic therapy at COPD exacerbations: Rob Wilson
Non invasive ventilatory support: Mark Elliott and Stanley Miller
Invasive ventilation and weaning at COPD exacerbation: Antonio Anzueto
Oxygen therapy at exacerbations: Tony Davison and Luke Wilson
End of life issues and COPD exacerbations: Anita Simonds
Novel models of care for COPD exacerbations: Martyn Partridge
Physiotherapy airway clearance at exacerbation: Christine Mikelsons and Rachel Garrod
COPD exacerbation and pulmonary rehabilitation: Mike Polkey and William Mann
PART V PREVENTION OF COPD EXACERBATION
Pharmacological prevention of COPD exacerbations: Leo Fabbri
Early intervention and self-management in exacerbation prevention: Jean Bourbeau
Immunological interventions: Phillip Poole
Home mechanical ventilation and oxygen therapy: Gerry Criner and Nat Marchetti
PART VI ISSUES FOR STUDIES OF COPD EXACERBATIONS
Design of trials for COPD exacerbations: Fernando Martinez
Statistical considerations for COPD exacerbation trials: Shawn Aaron
Future development in COPD exacerbations: Peter Barnes
Biography
JADWIGA A. WEDZICHA is Professor of Respiratory Medicine at the University College London and Honorary Consultant Physician, Royal Free Hospital NHS Trust, London, UK. She received her M.D. from the University of London, London, UK. Dr. Wedzicha has a major interest in the causes, mechanisms, and impact of COPD exacerbations and has published extensively on this topic. She also is an expert on home oxygen therapy and non-invasive ventilation in COPD patients. Dr. Wedzicha has chaired the British Thoracic Society (BTS) working group on home oxygen therapy, is currently chairing the BTS Home Oxygen Guidelines Group, and is a member of the Department of Health’s External Stakeholders Advisory Group for the Home Oxygen Service. She was a member of the Guideline Development Group for the NICE COPD guidelines and the External Reference Group (ERG) of the COPD National Service Framework (NSF). Dr. Wedzicha directs an active internationally recognized research group into aspects of COPD exacerbations with major grant funding. She is currently Editor-in-Chief of the respiratory journal Thorax, a member of the British Medical Journal advisory board, and an editorial board member for a number of international journals.
FERNANDO J. MARTINEZ is Medical Director of Pulmonary Diagnostic Services; Pulmonary Director of the Cough/Dyspnea Clinic; Associate Director of Bronchoscopy Service; Director of the Lung Volume Reduction Program; Professor of Pulmonary and Critical Care Medicine; and Co-Medical Director of the Lung Transplantation Program, the University of Michigan Health System, Ann Arbor, Michigan, USA. Dr. Martinez received his M.D. from the University of Florida School of Medicine, Gainesville, Florida, USA. From 2002 to the present, he has been named on both the national and Midwest "Best Doctors in America" lists, in addition to "Metro Detroit’s Best Doctors" list. Dr. Martinez is an active member of several professional organizations, including the American College of Chest Physicians, the American Thoracic Society, and the American Association of Cardiovascular and Pulmonary Rehabilitation. He is Associate Editor of the American Journal of Respiratory and Critical Care Medicine, and he serves on the editorial and review boards of several other journal publications. Dr. Martinez is an accomplished author/contributor and invited lecturer, and has received numerous grants to research respiratory health and disease.