1st Edition
A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery
Assay Development for Protein Kinases and Phosphatases. Fluorescence-Based Biochemical Protease Assay Formats. Assay Development for Nuclear Hormone Receptors. Assay Development for G Protein-Coupled Receptors and Ion Channels. Assay Development for Heat Shock Proteins. Assay Development for Cell Viability and Apoptosis for High Throughput Screening. Assay Development for Antimicrobial Drug Discovery. Image-Based High Content Screening. Application of RNA Interference in Drug Discovery. Assay Development Using Primary and Primary-Like Cells. Screening Automation. Compound Library Management. Unique Discovery Aspects of Utilizing Botanical Sources. Screening Informatics. Index.
Biography
Taosheng Chen earned a BS in biophysics and an MS in molecular cell biology from Fudan University in Shanghai, China. He received his PhD in cell and molecular biology from the University of Vermont at Burlington. Dr. Chen joined the faculty of the Department of Chemical Biology and Therapeutics and became director of the HTS Center at the St. Jude Children’s Research Hospital in Memphis in 2006. His laboratory focuses on studying the regulation of transcription factors and their implications in drug metabolism and drug resistance as well as in pediatric cancers. Dr. Chen has authored more than 20 peer-reviewed articles in the areas of cancer biology, drug metabolism, signal transduction, and drug discovery technology.
