1st Edition
A Primate Model for the Study of Colitis and Colonic Carcinoma The Cotton-Top Tamarin (Saguinus oedipus)
By Neal K. Clapp
Copyright 1993
352 Pages
by
CRC Press
352 Pages
by
CRC Press
Also available as eBook on:
A Primate Model for the Study of Colitis and Colonic Carcinoma describes recent observations of the prevalence, pathogenesis, natural history, and time-course of idiopathic colitis and colonic carcinoma in the Cotton-Top Tamarin (CTT) model. Results of colonoscopy and mucosal biopsy are shown to evaluate the therapeutic efficacy of new anti-colitic agents. The contributions of antigenic profiles... Read more
Part 1: Historical Background of Callitrichids 1. The Columbian Cotton-Top Tamarin in the Wild 2. Breeding the Cotton-Top Tamarin - Saguinus oedipus - in Captivity 3. Callitrichid Nutrition. Inflammatory Bowel Disease in Callitrichids 4. Natural History, Time Course, and Pathogenesis of Idiopathic Colitis in Cotton-Top Tamarins - Saguinus Oedipus 5. The Prevalence of Idiopathic Colitis in the New England Regional Primate Research Center Cotton-Top Tamarin - Saguinus oedipus 6. An Antigenic Profile in Cotton-Top Tamarins-Saguinus oedipus. A Model for Human Inflammatory Bowel Disease and Colorectal Cancer 7. Extra-Intestinal Manifestations of Cotton-Top Tamarin Colitis 8. A Protocol to Evaluate the Efficacy of Anti-Colitic Agents Against Ulcerative Colitis in Cotton-Top Tamarins 9. Coronaviruses in Tamarin and Marmoset Colitis 10. Do Repeated Colonic Mucosal Biopsies Impact Mortality in Cotton-Top Tamarins? Colon Carcinoma in Saguinus oedipus 11. Spontaneous Colonic Carcinoma Observations in the Oak Ridge Associated Universities 26-year-old Cotton-Top Tamarin (Saguinus oedipus) Colony 12. Genetic Epidemiology of Colon 13. Prevalence of Colonic Carcinoma in Cotton-Top Tamarin Colonies Throughout the World 14. Early Colonic Carcinoma Development in Cotton-Top Tamarins: Evidence of Promotion by Colitic Episodes? 15. Death Rates with Age from All Causes and Colonic Carcinoma and Causes in Wild-Caught and Colony-Born Cotton-Top Tamarins 16. Tamarin Colon Cancer and Flow Cytometry. Physiologic Changes and Markers Associated with Colon Disease 17. Fecal Steroids in Tamarins and Marmosets 18. A Serum Marker for Colon Cancer Detection: The Use of the Cotton-Top Tamarin 19. Colonic Glycoprotein Heterogeneity in the Cotton-Top Tamarin: Glycoconjugate Modification Associated with the Nonhuman Primate Model of Inflammatory Bowel Disease and Colonic Cancer 20. Polyamine Metabolism in Colonic Diseases 21. Immunobiology of the Cotton-Top Tamarin 22. Scintigraphic Imaging of Tamarin Colectoral Cancer with Radiolabeled Monoclonal Antibodies. E. Summary 23. Future Directions for Colon Disease Research Using Cotton-Top Tamarins
Biography
Neal K. Clapp
