312 Pages
23 B/W Illustrations
by
CRC Press
312 Pages
by
CRC Press
Also available as eBook on:
The Basal ganglia, to adopt a phrase of Churchill's, are "a riddle wrapped in a mystery, inside an enigma." And although there is a wealth of information available on them, this research field remains controversial due in part to the diverse number of disciplines involved. A Theory of the Basal Ganglia and Their Disorders provides a clear, coherent view of basal ganglia that integrates evidence... Read more
THE FRAMEWORK FOR NORMAL BASAL GANGLIONIC FUNCTION
Introduction: Background to the Dynamics of the Basal Ganglia
The Cortico-Thalamo-Hippocampal Excitatory Network: Substrate for Cell Assemblies and Associative Operations
Definition of Executive Functions
The "Motor Thalamus": Target of Executive Decisions?
The Striatum: Functional Significance and "Direct" Connectivity to Output Nuclei of the Basal Ganglia
The Striatum: Detector and Encoder of Motivationally Significant Outcomes of Behavior and Deployer of Motivationally Favorable Behaviors
Functional Subdivisions within Each Component of the Basal Ganglia
The "Credit Assignment Problem"
Morphological Evidence about the Fine Distribution of Connections in the Basal Ganglia
Cybernetic Interpretations Derived from Quantitative Synaptology
Collateral Inhibition in the Striatum
The "Indirect" Pathways from Striatum to Basal Ganglia Output Nuclei, and Their Relation to the "Direct" Pathway
Overall Patterns of Connectivity
Segregation versus Overlap of "Direct" and "Indirect" Pathways from Striatum to Thalamus
The "Credit Assignment Problem" in the Indirect Pathway
Evidence on the Relative Role of "Direct" and "Indirect" Pathways
Theories of Basal Ganglionic Function
Early Theories
Synopsis of Key Issues
The "Scaling of Movement" Hypothesis
The "Focused Selection" Hypothesis
A More Complete Version of the "Focused Selection" Theory, Including Predictions
Comparison with an Earlier Theory of the Basal Ganglia: Significance of Cell Assemblies
Dynamics of Neural Activity in Structures of the Basal Ganglia and the Nature of the Neural Code in These Structures
Synopsis of Part I and Predictions Derived from It
INTERPRETATION OF SYMPTOMS OF DISEASES OF THE BASAL GANGLIA
Introduction
General Comments
Neuropathology and Pathophysiology of Disorders of the Basal Ganglia
Huntington's Disease
Parkinson's Disease and Parkinsonian Syndromes
Introduction
The "Goad and the Halter" in Parkinson's Disease
Coactivation of Striatal Neurons and Cognitive Problems Associated with Parkinsonian Syndromes
Inflexibility of Adjustments of Posture and Gait in Parkinson's Disease
The Role of the Subthalamus in Production of Parkinsonian Symptoms
Burst Firing in Components of the Basal Ganglia and Parkinsonian Tremor
Direct Connections from Basal Ganglia to Brain Stem, and Their Role in Parkinsonian Akinesia and Rigidity
Parkinson's Disease: Summary
Dopamine-Dependent Psychosis
Introduction
Development of the Dopamine Hypothesis of Psychosis
Neural Dynamics in the Basal Ganglia When Dopaminergic Tone is Elevated
Overactivity of Striatal Dopamine in Relation to the Symptoms of Psychosis
Pharmacology of Psychosis
Positive Feedback between Striatum and Cortex in the Generation of Psychosis
Syndromes Arising as Complications of Prolonged Underactivity of Striatal Dopamine Mechanism, and Other Disorders of the Basal Ganglia
Introduction
Reasons for Identifying Striatal Cholinergic Cell Loss as the Origin of the Four Syndromes
Phenomenology of Peak Dose Dyskinesia and Tardive Dyskinesia
Dyskinesias, Stereotypy, Refractory Psychosis and Other Behavioral Pathologies Related to High-Dopamine States without a Prior History of Prolonged Dopaminergic Underactivity
Pharmacological Theory: Involvement of Dopaminergic and Cholinergic Receptor Subtypes
Other Disorders Involving the Basal Ganglia
Synopsis of Part II and Predictions Derived from It
Appendix 1: Abbreviations
Appendix 2: Pharmacological Agents and Their Actions References
Index
Introduction: Background to the Dynamics of the Basal Ganglia
The Cortico-Thalamo-Hippocampal Excitatory Network: Substrate for Cell Assemblies and Associative Operations
Definition of Executive Functions
The "Motor Thalamus": Target of Executive Decisions?
The Striatum: Functional Significance and "Direct" Connectivity to Output Nuclei of the Basal Ganglia
The Striatum: Detector and Encoder of Motivationally Significant Outcomes of Behavior and Deployer of Motivationally Favorable Behaviors
Functional Subdivisions within Each Component of the Basal Ganglia
The "Credit Assignment Problem"
Morphological Evidence about the Fine Distribution of Connections in the Basal Ganglia
Cybernetic Interpretations Derived from Quantitative Synaptology
Collateral Inhibition in the Striatum
The "Indirect" Pathways from Striatum to Basal Ganglia Output Nuclei, and Their Relation to the "Direct" Pathway
Overall Patterns of Connectivity
Segregation versus Overlap of "Direct" and "Indirect" Pathways from Striatum to Thalamus
The "Credit Assignment Problem" in the Indirect Pathway
Evidence on the Relative Role of "Direct" and "Indirect" Pathways
Theories of Basal Ganglionic Function
Early Theories
Synopsis of Key Issues
The "Scaling of Movement" Hypothesis
The "Focused Selection" Hypothesis
A More Complete Version of the "Focused Selection" Theory, Including Predictions
Comparison with an Earlier Theory of the Basal Ganglia: Significance of Cell Assemblies
Dynamics of Neural Activity in Structures of the Basal Ganglia and the Nature of the Neural Code in These Structures
Synopsis of Part I and Predictions Derived from It
INTERPRETATION OF SYMPTOMS OF DISEASES OF THE BASAL GANGLIA
Introduction
General Comments
Neuropathology and Pathophysiology of Disorders of the Basal Ganglia
Huntington's Disease
Parkinson's Disease and Parkinsonian Syndromes
Introduction
The "Goad and the Halter" in Parkinson's Disease
Coactivation of Striatal Neurons and Cognitive Problems Associated with Parkinsonian Syndromes
Inflexibility of Adjustments of Posture and Gait in Parkinson's Disease
The Role of the Subthalamus in Production of Parkinsonian Symptoms
Burst Firing in Components of the Basal Ganglia and Parkinsonian Tremor
Direct Connections from Basal Ganglia to Brain Stem, and Their Role in Parkinsonian Akinesia and Rigidity
Parkinson's Disease: Summary
Dopamine-Dependent Psychosis
Introduction
Development of the Dopamine Hypothesis of Psychosis
Neural Dynamics in the Basal Ganglia When Dopaminergic Tone is Elevated
Overactivity of Striatal Dopamine in Relation to the Symptoms of Psychosis
Pharmacology of Psychosis
Positive Feedback between Striatum and Cortex in the Generation of Psychosis
Syndromes Arising as Complications of Prolonged Underactivity of Striatal Dopamine Mechanism, and Other Disorders of the Basal Ganglia
Introduction
Reasons for Identifying Striatal Cholinergic Cell Loss as the Origin of the Four Syndromes
Phenomenology of Peak Dose Dyskinesia and Tardive Dyskinesia
Dyskinesias, Stereotypy, Refractory Psychosis and Other Behavioral Pathologies Related to High-Dopamine States without a Prior History of Prolonged Dopaminergic Underactivity
Pharmacological Theory: Involvement of Dopaminergic and Cholinergic Receptor Subtypes
Other Disorders Involving the Basal Ganglia
Synopsis of Part II and Predictions Derived from It
Appendix 1: Abbreviations
Appendix 2: Pharmacological Agents and Their Actions References
Index
Biography
Robert Miller
"Miller’s knowledge of the anatomy of neurological disorders is impressive. Only a person with a lifetime of experience in basal ganglia research could pull together such a wide range of information into a coherent model. We can all be grateful for the work of researchers like Robert Miller who have persevered for so many years in this area and are giving us all a coherent model of basal ganglia function."
– James J. Jakubow in PsycCRITIQUES, Volume 54, No. 35, 2008
