It is well established tht the intial interaction of prolactin with its target cells is with specific receptor molecules located on the external surface of the plasma membrane. Subsequent to the prolactin-receptor interaction, however, the molecular events that culminate in the regulation of biological processes are not totally understood. This book was assembled to review and analyse the currently available information relative to the molecular events involved in the actions of prolactin on cells. Hopefully, the assimilation of this information will provide the basis for ultimately determining the sequence of molecular reactions by which prolactin expresses its biological responses.
1. The Activation of Molecular Events by Prolactin 2. Prolactin Interaction with its Receptors and the Relationship to the Subsequent Regulation of Metabolic Processes 3. Actions of Prolactin on the Brain 4. Models of Prolactin Action in Nonmammalian Vertebrates 5. Prolactin Regulation of Membrane Fluidity and Prostaglandin Formation 6. Role of Calcium Ions and the Phospholipids in the Prolactin Regulation 7. Synergistic Actions of Glucocorticoid and Prolactin in Murine Milk-Protein Gene Expression 8. Role of Polyamines in Prolactin Actions 9. Prolactin and the Regulation of Secretion Including Membrane Flow- Potential Roles for Tubulin and Microtubules 10. Protein Phosphorylation of Prolactin Target Tissue- Mammary Gland 11. Prolactin, Growth Factors, and Cell Growth