Acute Phase Proteins covers all major aspects of acute phase proteins (APP) starting with molecular mechanisms regulating their synthesis and ending with their functional significance. The book features 36 chapters addressing such topics as acute phase response and the APP; major APP and their structure and functions; regulation of APP synthesis, the cytokines and hormones implicated in these processes, and molecular mechanisms involved; signal transduction of cytokines in hepatocytes and posttranscriptional processes; and quantitative and qualitative evaluation of APP in clinical practice. The book will be an important reference for immunologists, molecular biologists, cellular biologists, biochemists, and clinical chemists.
Introduction to the Acute Phase Response: The Acute Phase Response: An Overview (I. Kushner and A. Mackiewicz). The Negative Acute Phase Proteins (A.R. Aldred and G. Schreiber). Extrahepatic Synthesis of Acute Phase Proteins (G. Schreiber and A.R. Aldred). The Major Acute Phase Proteins-Their Structure and Possible Function in Acute Phase Response: Structure and Function of Human C-Reactive Protein (A. Agrawal, J.M. Kilpatrick, and J.E. Volanakis). The SAA Lipoprotein Family (N. Eriksen, R.L. Meek, and E. Benditt). The a1-Acid Glycoprotein: Structure and Possible Functions in the Acute Phase Response (C.B. Eap and P. Baumann). Proteinase Inhibitors: An Overview of Their Structure and Possible Function in the Acute Phase (G. Salvesen and J.J. Enghild). a1-Antitrypsin: Structure, Function, Physiology (D.H. Perlmutter). Fibrinogen: A Multifunctional Acute-Phase Protein (G.M. Fuller). Haptoglobin: Retrospectives and Perspectives (W. Dobryszycka). The Acute Phase Complement Proteins (H.R. Colten). Rat a2-Macroglobulin and Related a-Macroglobulins in the Acute Phase Response (R.C. Roberts). Rat Thiostatin: Structure and Possible Function in the Acute Phase Response (G. Schreiber and T.J. Cole). Systems in Which to Study Regulation of Acute Phase Proteins: Experimental Systems for Studying Hepatic Acute Phase Response (K.-A. Won, S.P. Campos, and H. Baumann). The Cytokines and Hormones Implicated in Acute Phase Proteins Regulation: Biological Perspective of Cytokine and Hormone Networks (A. Koj, J. Gauldie, and H. Baumann). Interleukin-6 (P.B. Sehgal). Interleukin-11: Molecular Biology, Biological Activities and Possible Signaling Pathways (Y.-C. Yang). The Role of Oncostatin M in the Acute Phase Response (C.D. Richards and M. Shoyab). Tumor Necrosis Factor (P.G.G. Brouckaert and C. Libert). Interleukin-6 Receptor (S. Rose-John and P.C. Heinrich). Regulation of Acute Phase Protein Gene Expression: Regulation of C-Reactive Protein, Haptoglobin, and Hemopexin Gene Expression (D.P. Ramji, R. Cortese, and G. Ciliberto). Serum Amyloid A Gene Regulation (P. Woo, M. Edbrooke, J. Betts, G. Watson, and P. Francis). Regulation of a1-Acid Glycoprotein Genes and Relationship to Other Type 1 Acute Phase Plasma Proteins (H. Baumann, K.R. Prowse, K.-A. Won, and S. Marinkovic-Pajovic). Transcriptional Regulation of the Human C3 Gene (G.J. Darlington, D.R. Wilson, and T.S.-C. Juan). Regulation of the a2-Macroglobulin Gene (F. Horn, U.M. Wegenka, and P.C. Heinrich). Regulation of the Rat a2 Macroglobulin Gene by Interleukin-6 and Leukemia Inhibitory Factor (G.M. Hocke, M.-Z. Cui, J.A. Ripperger, and G.H. Fey). Regulation of the Rat Thiostatin Gene (T.J. Cole and G. Schreiber). Cytokine Regulation of the Mouse SAA Gene Family (J.D. Sipe, H. Rokita, and F.C. de Beer). Signal Transduction of Cytokines in Hepatocytes: Signal Transduction Mechanisms Regulating Cytokine-Mediated Induction of Acute Phase Proteins Cytokine-Mediated Induction (M.K. Ganapathi). Posttranscriptional Processes: Intracellular Maturation of Acute Phase Proteins (E. Fries and M.E. Sjöberg). Control of Glycosylation Alterations of Acute Phase Glycoproteins (W. van Dijk and A. Mackiewicz). Post-Translational Regulation of C-Reactive Protein Secretion (S.S. Macintyre and P.A. Kalonick). Clinical Applications: Cytokine Measurements in Disease (D. Heney, R.E. Banks, J.T. Whicher, and S.W. Evans). Diagnostic and Prognostic Value of Interleukin-6 Measurements in Human Disease (P.B. Sehgal). The Measurement of Acute Phase Proteins as Disease Markers (J.T. Whicher, R.E. Banks, D. Thompson, and S.W. Evans). Glycoforms of a1-acid Glycoprotein as Disease Markers (A. Mackiewicz and A. Gorny).