Acute Trauma-Induced Coagulopathy Mechanisms, Diagnostics, and Management Strategies

Chapter 1: Introduction to Trauma Induced Coagulopathy

Tushar Sehgal, Venencia Albert, Babita Gupta Arulselvi Subramanian

Chapter 2: Mechanism and Pathophysiology of Trauma Induced Coagulopathy

Abhishek Satapathy, Babita Gupta, Venencia Albert, Nitin Tiwari, Arulselvi Subramanian

Chapter 3: Risk Factors and Contributing Elements to Trauma Induced Coagulopathy

Vineeth Chandran, Ajay A

Chapter 4: Traumatic Brain Injury Associated Coagulopathy

Venencia Albert, Arulselvi Subramanian, Deepak Agrawal

Chapter 5: Diagnostic Assessment of Trauma Induced Coagulopathy

Venencia Albert, Arulselvi Subramanian

Chapter 6: Scoring Systems to Assess the Probability of Massive Transfusion in Trauma

Joses Dany James, Vignesh Kumar, Sruthi Kandaswamy

Chapter 7: Principles and Practices in Managing Trauma Induced Coagulopathy

7.1. Management Strategies for Trauma Induced Coagulopathy

Sharmishtha Pathak,Babita Gupta

7.2. Transfusion Management in Trauma Induced Coagulopathy

Aparna Krishna, Arulselvi Subramanian, Venencia Albert

Chapter 8: Impact of Trauma Induced Coagulopathy on Clinical Outcomes

Abhishek Singh, Nistha Malik, Hemant Choudhary, Nishtha Chawla

Chapter 9: Future Directions in Trauma Care

Jasmita Das, Richa Chauhan

Chapter 10: Case-Based Learning in Trauma Induced Coagulopathy: National and International Experiences

Case 1: Early Recognition and Intervention in Two Trauma Cases

Ajay A

Case 2: Acquired Haemophilia a Mimicking Trauma Induced Coagulopathy in a Young Polytrauma Patient

Andrea Capponi

Case 3: Massive Transfusion in Isolated Maxillofacial Trauma: A High-Acuity Low-Occurrence Situation

Anukarthika S, Amrithanand V T, Aparna Krishna

Case 4: Use of Prothrombin Complex Concentrate in Paediatric Patients with TBI-Associated Coagulopathy

Venencia Albert, Arulselvi Subramanian, Deepak Agrawal

Case 5: Massive Transfusion in Trauma Induced Coagulopathy: Case Report of a Polytrauma Patient

Radheshyam Meher, Arulselvi Subramanian, Amit Gupta

Biography

Dr. Venencia Albert is a Research Scientist at the Division of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences. Her work focuses on trauma care, coagulation disorders, neurosurgery, and infectious disease epidemiology. She earned her Ph.D. in Laboratory Medicine, studying early markers of trauma-induced coagulopathy in severe traumatic brain injury, contributing to the understanding of early coagulation changes after brain injury. She has published widely in peer-reviewed journals and presented her work at international forums, including the World Congress of Neurology. She has received several recognitions, including a young researcher award and multiple travel fellowships. Dr. Albert has been involved in national research initiatives under the Indian Council of Medical Research, including fungal disease registries and foodborne pathogen surveillance. She has contributed to scientific publishing through the Indian Journal of Medical Research, served as Guest Editor for a special issue in Clinical and Applied Thrombosis/Hemostasis (CATH), SAGE Journals, and is currently the Associate Editor for the Journal of Pediatric Neurosciences. Her interests include diagnostics, translational medicine, and predictive analytics to improve trauma care and public health.

Dr. S. Arulselvi is a distinguished professor and researcher in the field of laboratory medicine, with a specialization in trauma-induced coagulopathy. Other interests include post trauma cognitive changes, trauma immunology and pathology. She is currently serving in the Department of Laboratory Medicine at the Jai Prakash Narayan Apex Trauma Center, AIIMS, New Delhi. With over two decades of academic and research experience, Dr. Arulselvi has made significant contributions to understanding the pathophysiology and management of coagulopathy in trauma and critical care settings. Her extensive research portfolio includes over 200 publications in high-impact peer-reviewed journals, reflecting her expertise in hemostatic abnormalities, blood component therapy, and diagnostic innovations in coagulation disorders. She has been actively involved in developing clinical guidelines for managing coagulopathy and optimizing transfusion strategies in critically injured patients. Dr. Arulselvi is a dedicated mentor and has guided numerous postgraduate students, research fellows, and clinical scientists in laboratory medicine and transfusion research. She is also a key investigator in several studies on trauma-induced coagulopathy and has contributed significantly to national and international collaborations in trauma research.

Dr. Deepak Agrawal is currently a professor of neurosurgery and Gamma-Knife at AIIMS, New Delhi. Dr. Agrawal has a keen interest in research and innovation and is co-inventor of the world's cheapest and smallest ventilator named AgVa. He has seven patents to his credit. He has done more than 1000 GK procedures and introduced several innovations in GK unit at AIIMS. He has won several national and international awards for his research, including the American Congress of Neurosurgeons (CNS) Young Neurosurgeon of the Year award and the DST ‘BIG’ grant. He has more than 300 indexed publications and has been the principal investigator in several multicentric projects, including receiving an RO3 grant from the NIH. He has been the editor of the Journal of Peripheral Nerve Surgery (JPNS) and the Indian Journal of Neurotrauma (IJNT) and has been credited with improving the impact factor of these journals. Recently, he has become the editor of the Journal of Pediatric Neurosciences (JPN).