A comprehensive review of the scientific and clinical aspects of acute and chronic cough, this reference focuses on recent developments in our understanding of the molecular biology of putative cough receptors, the neural mechanisms involved in the afferent and efferent limbs, the central processing of the cough reflex, and peptides and other substances that may mediate or modulate the cough reflex. With chapters written by acknowledged authorities in the field, this handbook covers current and potential therapeutic agents, various methodologies to measure cough reflex sensitivity, and clinical approaches for the assessment of chronic cough in adults and children.
"…I congratulate the editors on assembling an international field of true experts in the many clinical and scientific aspects of cough."
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Molecular Biology of the Vanilloid VR1 and Related Receptors. Putative Cough Receptors. Afferent Cough Reflex Pathways. Central Cough Mechanisms: Neuroanatomy and Neurophysiology. Role of Tachykinins in Cough. ACE Inhibitor Induced Cough: Lessons from Animal Models. Pharmacological Modulation of the Cough Reflex. Novel Therapeutic Approaches: Nociceptin Agonists and Other Agents. Analysis of the Cough Sound. Cough Induced by Inhalation of Non-Isotonic Agents. Capsaicin Inhalation Cough Challenge. Acid and Other Forms of Inhalation Cough Challenge. Cough Reflex Sensitivity in Health and Disease. Cough and Gender. Acute Cough: Epidemiology, Mechanisms, and Treatment. Systematic Evaluation of Chronic Cough. Pathogenesis of Cough in Gastroesophageal Reflux Disease. Management of Gastroesophageal Reflux Disease Related Chronic Cough. Cough Variant Asthma. Eosinophilic Bronchitis. Upper Airway Causes of Chronic Cough. Psychogenic Cough. Chronic Cough in Children. Impact of Cough on Health Status