Adaptive Motion Compensation in Radiotherapy  book cover
1st Edition

Adaptive Motion Compensation in Radiotherapy

Edited By

Martin J. Murphy

ISBN 9781138374294
Published November 28, 2018 by CRC Press
165 Pages 23 Color & 122 B/W Illustrations

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Book Description

External-beam radiotherapy has long been challenged by the simple fact that patients can (and do) move during the delivery of radiation. Recent advances in imaging and beam delivery technologies have made the solution—adapting delivery to natural movement—a practical reality. Adaptive Motion Compensation in Radiotherapy provides the first detailed treatment of online interventional techniques for motion compensation radiotherapy.

This authoritative book discusses:

  • Each of the contributing elements of a motion-adaptive system, including target detection and tracking, beam adaptation, and patient realignment
  • Treatment planning issues that arise when the patient and internal target are mobile
  • Integrated motion-adaptive systems in clinical use or at advanced stages of development
  • System control functions essential to any therapy device operating in a near-autonomous manner with limited human interaction
  • Necessary motion-detection methodology, repositioning techniques, and approaches to interpreting and responding to target movement data in real time

Medical therapy with external beams of radiation began as a two-dimensional technology in a three-dimensional world. However, in all but a limited number of scenarios, movement introduces the fourth dimension of time to the treatment problem. Motion-adaptive radiation therapy represents a truly four-dimensional solution to an inherently four-dimensional problem. From these chapters, readers will gain not only an understanding of the technical aspects and capabilities of motion adaptation but also practical clinical insights into planning and carrying out various types of motion-adaptive radiotherapy treatment.

Table of Contents

Martin J. Murphy
Real-time tumor localization
Ruijiang Li, Laura I. Cerviño, and Steve B. Jiang
Theoretical aspects of target detection and tracking
Gregory C. Sharp
Respiratory gating
Geoffrey D. Hugo and Martin J. Murphy
The CyberKnife® image-guided frameless radiosurgery system
Martin J. Murphy
Fundamentals of tracking with a linac MLC
Dualta McQuaid and Steve Webb
Couch-based target alignment
Kathleen T. Malinowski and Warren D. D’Souza
Robotic LINAC tracking based on correlation and prediction
Florist Ernst and Achim Schweikard
Treatment planning for motion adaptation in radiation therapy
Alexander Schlaefer
Treatment planning for motion management via DMLC tracking
Lech Papiez and Dharanipathy Rangaraj
Real-time motion adaptation in Tomotherapy® using a binary MLC
Weiguo Lu, Mingli Chen, Carl Mauer, and Gustavo Olivera
Combination of a LINAC with 1.5 T MRI for real-time image-guided radiotherapy
Jan J. W. Lagendijk, Bas W. Raaymakers, and Marco Van Vulpen
The ViewRayTM system
Daniel Low
Fault detection in image-based tracking
Gregory C. Sharp

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Dr. Martin J. Murphy received his Ph.D. in physics from the University of Chicago in 1980. Following postdoctoral fellowships in nuclear physics at the University of California/Berkeley and the University of Washington and a stint as a research scientist in gamma-ray astronomy at the Lockheed Palo Alto Research Laboratories, he entered the field of radiation therapy research and development in 1992 as Director of System Development of the CyberKnife at Accuray Incorporated. In 1995, he joined the Department of Radiation Oncology at Stanford University as a senior research scientist to continue development of the CyberKnife’s image guidance and target tracking capabilities. In 2003, Dr Murphy joined the Department of Radiation Oncology at Virginia Commonwealth University, where he is presently engaged in several research programs involving medical image registration, CT reconstruction, and real-time motion-adaptive control systems.


"The book has contributions from many eminent scientists and each chapter is well written and informative. … an informative and useful book that will be of particular interest to those seeking an overview of the different means of achieving adaptive motion compensation in radiotherapy that either are or may be available in the near future."
—Chris Bragg, Journal of Radiotherapy in Practice, 2013