Adaptive Motion Compensation in Radiotherapy: 1st Edition (Paperback) book cover

Adaptive Motion Compensation in Radiotherapy

1st Edition

Edited by Martin J. Murphy

CRC Press

165 pages | 23 Color Illus. | 122 B/W Illus.

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External-beam radiotherapy has long been challenged by the simple fact that patients can (and do) move during the delivery of radiation. Recent advances in imaging and beam delivery technologies have made the solution—adapting delivery to natural movement—a practical reality. Adaptive Motion Compensation in Radiotherapy provides the first detailed treatment of online interventional techniques for motion compensation radiotherapy.

This authoritative book discusses:

  • Each of the contributing elements of a motion-adaptive system, including target detection and tracking, beam adaptation, and patient realignment
  • Treatment planning issues that arise when the patient and internal target are mobile
  • Integrated motion-adaptive systems in clinical use or at advanced stages of development
  • System control functions essential to any therapy device operating in a near-autonomous manner with limited human interaction
  • Necessary motion-detection methodology, repositioning techniques, and approaches to interpreting and responding to target movement data in real time

Medical therapy with external beams of radiation began as a two-dimensional technology in a three-dimensional world. However, in all but a limited number of scenarios, movement introduces the fourth dimension of time to the treatment problem. Motion-adaptive radiation therapy represents a truly four-dimensional solution to an inherently four-dimensional problem. From these chapters, readers will gain not only an understanding of the technical aspects and capabilities of motion adaptation but also practical clinical insights into planning and carrying out various types of motion-adaptive radiotherapy treatment.


"The book has contributions from many eminent scientists and each chapter is well written and informative. … an informative and useful book that will be of particular interest to those seeking an overview of the different means of achieving adaptive motion compensation in radiotherapy that either are or may be available in the near future."

—Chris Bragg, Journal of Radiotherapy in Practice, 2013

Table of Contents


Martin J. Murphy

Real-time tumor localization

Ruijiang Li, Laura I. Cerviño, and Steve B. Jiang

Theoretical aspects of target detection and tracking

Gregory C. Sharp

Respiratory gating

Geoffrey D. Hugo and Martin J. Murphy

The CyberKnife® image-guided frameless radiosurgery system

Martin J. Murphy

Fundamentals of tracking with a linac MLC

Dualta McQuaid and Steve Webb

Couch-based target alignment

Kathleen T. Malinowski and Warren D. D’Souza

Robotic LINAC tracking based on correlation and prediction

Florist Ernst and Achim Schweikard

Treatment planning for motion adaptation in radiation therapy

Alexander Schlaefer

Treatment planning for motion management via DMLC tracking

Lech Papiez and Dharanipathy Rangaraj

Real-time motion adaptation in Tomotherapy® using a binary MLC

Weiguo Lu, Mingli Chen, Carl Mauer, and Gustavo Olivera

Combination of a LINAC with 1.5 T MRI for real-time image-guided radiotherapy

Jan J. W. Lagendijk, Bas W. Raaymakers, and Marco Van Vulpen

The ViewRayTM system

Daniel Low

Fault detection in image-based tracking

Gregory C. Sharp

About the Editor

Dr. Martin J. Murphy received his Ph.D. in physics from the University of Chicago in 1980. Following postdoctoral fellowships in nuclear physics at the University of California/Berkeley and the University of Washington and a stint as a research scientist in gamma-ray astronomy at the Lockheed Palo Alto Research Laboratories, he entered the field of radiation therapy research and development in 1992 as Director of System Development of the CyberKnife at Accuray Incorporated. In 1995, he joined the Department of Radiation Oncology at Stanford University as a senior research scientist to continue development of the CyberKnife’s image guidance and target tracking capabilities. In 2003, Dr Murphy joined the Department of Radiation Oncology at Virginia Commonwealth University, where he is presently engaged in several research programs involving medical image registration, CT reconstruction, and real-time motion-adaptive control systems.

About the Series

Imaging in Medical Diagnosis and Therapy

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
SCIENCE / Physics