After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature.
Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reader with a general overview of adenosine receptors, delving into molecular biology, cell biology, and pharmacology. Separate chapters focus on the role of adenosine receptors in regulating the function of the various cell types that are involved in immune responses. Further chapters delineate the role of purinergic signaling in the pathophysiology of a variety of disease states associated with an overzealous or insufficient immune response. These include autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer.
Much of the methodology and findings documented in this text may well lead to new therapeutic modalities for pathologies such as ischemia and reperfusion, heart disease, wound healing, tumors, pain, and a variety of central nervous system diseases including Parkinson’s, Alzheimer’s, and epilepsy, as well as mood and sleep disorders. This resource provides background and direction for those researchers entering the field of adenosine and inflammatory disease, and provides a comprehensive reference for experienced investigators.
Table of Contents
Adenosine Receptor Pharmacology; Karl-Norbert Klotz
Medicinal Chemistry of Adenosine A3 Receptors; Kenneth A. Jacobson, Yong Chul Kim, Bhalchandra V. Joshi, Zhan-Guo Gao
The role of CD73 in the Generation of Extracellular Adenosine for Adenosine Receptor Signaling; Masahide Takedachi, Sean P. Colgan, Linda F. Thompson
Regulation of Monocyte/Macrophage Function by Adenosine Receptors; György Haskó, Csaba Szabó
Impaired Lymphocyte Activation in the Presence of Adenosine: Mechanisms and Physiologic Relevance; Jonathan Blay, David W. Hoskin
Adenosine and Neutrophil Functions; Marc Pouliot
Dendritic Cells Regulated by Nucleotides and Nucleosides; Johannes Norgauer, Marco Idzko, Elisabeth Panther, Giampiero Girolomoni, Mirjana Ziemer
Adenosine and Endothelial Cell Function; Igor Feoktistov, Italo Biaggioni
Adenosine A2B Receptor in the Intestinal Epithelia; Shanthi V. Sitaraman, Vasantha Kolachala, Pallavi Garg
Adenosine, Adenosine Receptors and the Regulation of Glial Cells in Neuronal Damage; Gunnar Schulte, Elisabetta Daré, Katrin Färber, Bertil B Fredholm
Adenosine Receptors, Wound Healing and Angiogenesis; Aneesh Sheth, Bruce Cronstein
A2A Adenosine Receptors and Ischemia Reperfusion Injury; Courtney M. Lappas, Joel Linden
Adenosine Signaling in Chronic Lung Disease; Michael R. Blackburn
Role of Adenosine in the Control of Inflammatory Events Associated with Acute and Chronic Neurodegenerative Disorders; Jonathan D. Geiger, Lara Buscemi, Julie A. Fotheringham
Anti-Inflammatory And Cytoprotective Effects Of Inosine; Csaba Szabó, Domokos Gerô, György Haskó
Adenosine And Infection; Christopher Moore, Edward Martin, Gail Sullivan, Joel Linden, W. Michael Scheld
Regulation of Peripheral Inflammation by Spinal Adenosine; Sanna Rosengren, Gary S. Firestein
Adenosine, Tumors and Immunity; Pnina Fishman, Sara Bar-Yehuda, Lea Madi
Adenosine in Atherosclerosis; Allison B Reiss
Regulation of Macrophage-Dependent Angiogenesis by Adenosine and Toll-Like Receptors; Samuel Joseph Leibovich.
"… written by a number of prime experts in the field. … highly recommended to readers who are interested in the pharmacology of adenosine receptors."
– Christa E. Muller, PharmaCenter Bonn, Germany in ChemMedChem, 3, 2008