Advanced Electroporation Techniques in Biology and Medicine: 1st Edition (Paperback) book cover

Advanced Electroporation Techniques in Biology and Medicine

1st Edition

By Andrei G. Pakhomov, Damijan Miklavcic, Marko S. Markov

CRC Press

540 pages | 173 B/W Illus.

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A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of biomembranes by pulsed electric fields. Edited by experts and including contributions from pioneers in the field, the book focuses on biophysical mechanisms of electroporation and applications of this phenomenon in biomedical research and medicine.

The field of electroporation is now mature enough to move from journal pages to book covers. The book leads readers from the basics and history of electroporation, through mechanisms of membrane permeabilization in lipid bilayers and living cells, to electrically-mediated gene delivery and cancer therapy in animals and humans. This book is an interdisciplinary compilation intended broadly for biomedical and physical scientists, engineers, and clinicians. It can also be used as a textbook for students in advanced courses in biomedical engineering, molecular and cell biology, as well as in biophysics and clinical medicine.

Table of Contents

Basics of Electroporation

Physical Chemical Theory of Membrane Electroporation and Electrotransfer of Biogenic Agents, E. Neumann and S. Kakorin

Bioelectric Effect of Intense Nanosecond Pulses, K.H. Schoenbach

Induced Transmembrane Voltage—Theory, Modeling, and Experiments, T. Kotnik and G. Pucihar

Electroporation: A Review of Basic Problems in Theory and Experiment, M.S. Markov

Mechanisms of Electroporation in Lipid Systems

Electrodeformation, Electroporation, and Electrofusion of Cell-Sized Lipid Vesicles, R. Dimova

Fluorescent Methods in Evaluation of Nanopore Conductivity and Their Computational Validation, M. Kotulska, W. Dyrka, and P. Sadowski

Electroporation of Lipid Membranes: Insights from Molecular Dynamics Simulations, M. Tarek and L. Delemotte

Nanoscale Restructuring of Lipid Bilayers in Nanosecond Electric Fields, P.T. Vernier

Mechanisms of Electroporation of Cells

Nanopores: A Distinct Transmembrane Passageway in Electroporated Cells, A.G. Pakhomov and O.N. Pakhomova

Model of Cell Membrane Electroporation and Transmembrane Molecular Transport, D. Miklavčič and L. Towhidi

Kinetics of Pore Formation and Disappearance in the Cell during Electroporation, G. Saulis

The Pulse Intensity-Duration Dependency for Cell Membrane Electroporation, D. Miklavčič, G. Pucihar, A.M. Lebar, J. Krmelj, and L. Towhidi

Mechanisms of Electroporation in Tissues

Drug-Free, Solid Tumor Ablation by Electroporating Pulses: Mechanisms That Couple to Necrotic and Apoptotic Cell Death Pathways, A.T. Esser, K.C. Smith, T.R. Gowrishankar, and J.C. Weaver

Gene Electrotransfer: From Basic Processes to Preclinical Applications, J.-M. Escoffre, A. Paganin-Gioanni, E. Bellard, M. Golzio, M.-P. Rols, and J. Teissié

Technical Considerations

Modeling Electric Field Distribution In Vivo, N. Pavšelj, A. Županič, and D. Miklavčič

Concepts of Electroporation Pulse Generation and Overview of Electric Pulse Generators for Cell and Tissue Electroporation, M. Reberšek and D. Miklavčič

Generation of Ultrashort Pulses, J.F. Kolb

Nanosecond Pulsed Electric Field Delivery to Biological Samples: Difficulties and Potential Solutions, A. Silve, J. Villemejane, V. Joubert, A. Ivorra, and L.M. Mir

Applications of Electroporation

Translation of Electroporation-Mediated DNA Delivery to the Clinic, L.C. Heller and R. Heller

Clinical Electrochemotherapy: The Italian Experience, C.R. Rossi and L.G. Campana

Tumor Blood Flow–Modifying Effects of Electroporation and Electrochemotherapy—Experimental Evidence and Implications for the Therapy, T. Jarm, M. Cemazar, and G. Sersa

lectrochemotherapy as Part of an Immunotherapy Strategy in the Treatment of Cancer, J. Gehl

ombined Electrical Field and Ultrasound: A Nondrug-Based Method for Tumor Ablation, P.F. Forde, C. Twomey, G.C. O’ Sullivan, and D. M. Soden

Combined Modality Therapy: Electrochemotherapy with Tumor Irradiation, G. Sersa, S. Kranjc, and M. Cemazar

Irreversible Electroporation in Medicine, B. Rubinsky

Food and Biomaterials Processing Assisted by Electroporation, N. Lebovka and E. Vorobiev

In Vivo Electroporation: An Important Injury Mechanism in Electrical Shock Trauma, I. Barakat, J. Gallaher, H. Chen, and R.C. Lee


About the Series

Biological Effects of Electromagnetics

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
SCIENCE / Physics