Advanced Pharmaceutical Solids: 1st Edition (Hardback) book cover

Advanced Pharmaceutical Solids

1st Edition

By Jens T. Carstensen

CRC Press

536 pages

Purchasing Options:$ = USD
Hardback: 9780824704315
pub: 2000-10-24
eBook (VitalSource) : 9780429178856
pub: 2000-10-24
from $175.00

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This extensive reference/text explores the principles, instrumentation, processes, and programs of pharmaceutical solid science as well as new aspects on one-component systems, micromeritics, polymorphism, solid-state stability, cohesion, powder flow, blending, single- unit sustained release, and tablet coating.

Reveals unique approaches in pharmaceutical solid science not previously published in any other text!

Providing current data on crystallization, dissolution from particles and polydisperse populations, powder volumes and densities, comminution, wet granulation, and hard-shell capsules, Advanced Pharmaceutical Solids

  • describes moisture isotherms with crystalline solids

  • documents the effects of moisture on solid-state stability

  • highlights tablet physics and principles

  • explains sustained release by microencapsulation

  • presents prediction equations for solubility in binary solvents

  • discusses particle sizes and diameters

  • identifies Brunauer, Emmett, and Teller Isotherms

  • and more!

    Considering properties of solids, permeamitry and gas absorption methods, amorphates, and purification by pH-change precipitation, Advanced Pharmaceutical Solids is an essential reference for pharmacists; pharmaceutical scientists; medicinal, physical, surface, colloid, and analytical chemists and biochemists; and an effective text for upper-level undergraduate and graduate students in these disciplines.

  • Reviews


    …a comprehensive overview.

    "-Pharma Times

    "…would find good use as a textbook in a graduate level course on pharmaceutical solids…equally valuable as an information source for anyone seeking a brief overview of a particular area.

    "-Pharmaceutical Development Technology

    "…deserves a place on the bookshelves of any pharmaceutical scientist working on the development of solid dosage forms….

    …an excellent initial reference for advanced students and scientists working on solids.

    "-Pharmaceutical Research

    Table of Contents

    One-Component Systems

    Properties of Solids


    Particle Sizes and Diameters





    Moisture Isotherms with Crystalline Solids

    Drug Substance Considerations

    Melting Point Diagrams and Eutectics

    Dissolution from Particles and Surfaces

    Dissolution from Polydisperse Populations

    Solid-State Stability

    Effect of Moisture on Solid-State Stability

    Apparent Volumes and Densities


    Powder Flow



    Wet Granulation

    Hard-Shell Capsules

    Tablet Physics

    Physical Principles of Tablets

    Disintegration and Dissolution


    Coating of Tablets

    Single-Unit Sustained Release Dosage Forms

    Sustained Release by Microencapsulation

    About the Series

    Drugs and the Pharmaceutical Sciences

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    SCIENCE / Chemistry / Physical & Theoretical