Advanced Pharmaceutical Solids  book cover
1st Edition

Advanced Pharmaceutical Solids

ISBN 9780824704315
Published October 24, 2000 by CRC Press
536 Pages

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Book Description

This extensive reference/text explores the principles, instrumentation, processes, and programs of pharmaceutical solid science as well as new aspects on one-component systems, micromeritics, polymorphism, solid-state stability, cohesion, powder flow, blending, single- unit sustained release, and tablet coating.
Reveals unique approaches in pharmaceutical solid science not previously published in any other text!
Providing current data on crystallization, dissolution from particles and polydisperse populations, powder volumes and densities, comminution, wet granulation, and hard-shell capsules, Advanced Pharmaceutical Solids

  • describes moisture isotherms with crystalline solids
  • documents the effects of moisture on solid-state stability
  • highlights tablet physics and principles
  • explains sustained release by microencapsulation
  • presents prediction equations for solubility in binary solvents
  • discusses particle sizes and diameters
  • identifies Brunauer, Emmett, and Teller Isotherms
  • and more!
    Considering properties of solids, permeamitry and gas absorption methods, amorphates, and purification by pH-change precipitation, Advanced Pharmaceutical Solids is an essential reference for pharmacists; pharmaceutical scientists; medicinal, physical, surface, colloid, and analytical chemists and biochemists; and an effective text for upper-level undergraduate and graduate students in these disciplines.
  • Table of Contents

    One-Component Systems
    Properties of Solids
    Particle Sizes and Diameters
    Moisture Isotherms with Crystalline Solids
    Drug Substance Considerations
    Melting Point Diagrams and Eutectics
    Dissolution from Particles and Surfaces
    Dissolution from Polydisperse Populations
    Solid-State Stability
    Effect of Moisture on Solid-State Stability
    Apparent Volumes and Densities
    Powder Flow
    Wet Granulation
    Hard-Shell Capsules
    Tablet Physics
    Physical Principles of Tablets
    Disintegration and Dissolution
    Coating of Tablets
    Single-Unit Sustained Release Dosage Forms
    Sustained Release by Microencapsulation

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    …a comprehensive overview.
    "-Pharma Times

    "…would find good use as a textbook in a graduate level course on pharmaceutical solids…equally valuable as an information source for anyone seeking a brief overview of a particular area.
    "-Pharmaceutical Development Technology

    "…deserves a place on the bookshelves of any pharmaceutical scientist working on the development of solid dosage forms….
    …an excellent initial reference for advanced students and scientists working on solids.
    "-Pharmaceutical Research