For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to date information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. This volume considers the achievements and legacy of Lloyd R. Snider in separation science and analytical chemistry.
• Provides a historical perspective of the evolution of SMB technology together with a theoretical analysis of the most relevant underlying phenomena
• Presents a brief survey of the polar columns suitable for HILIC separations and pays special attention to the role of the mobile phase in RP and HILIC modes
• Describes recent strategies of method development in Kosmotropic chromatography
• Surveys the many approaches to avert the effects of temperature in reversed-phase liquid chromatographic separations
• Reviews separation of isotopic compounds by HPLC in relation to the advances of columns and stationary phases
Table of Contents
Advances in Simulated Moving Bed technology. Mobile phase effects in reversed-phase and hydrophilic interaction liquid chromatography. Kosmotropic chromatography of proteins: theory and practice. Using temperature control in reversed-phase liquid chromatography: Its use in focusing, stationary phases that are stable at high temperature, its effect on retention, and viscous dissipation. Isotopic separations indicating the efficiency and selectivity of HPLC columns and stationary phases. HPLC Method Dev LS influences
Dr. Nelu Grinberg retired in 2016 as a Distinguished Research Fellow in the Chemical Development Department at Boehringer Ingelheim Pharmaceuticals in Ridgefield, CT. Prior to this, he worked for sixteen years in the Analytical Department at Merck Research Laboratories in Rahway, NJ, where he was a Senior Research Fellow. He has authored and coauthored over 118 publications, including articles and book chapters. He is currently Editor and Chief of the Journal of Liquid Chromatography and Related Techniques, Editor of the book series Chromatographic Science Series, and Co-editor of the Advances in Chromatography series. He is also the President of the Connecticut Separation Science Council and a Koltoff fellow of the Hebrew University of Jerusalem. Dr. Grinberg obtained his Ph.D. in Chemistry from the Technical University of lasi in Romania. He conducted postdoctoral research with Professor Barry Karger at Northeastern University in Boston, Massachusetts, and with Professor Emanuel Gil-Av at The Weizmann Institute of Science in Rehovot, Israel.
Peter Carr received his B.S. in Chemistry (1965) from the Polytechnic Institute of Brooklyn where he worked with Professor Louis Meites, and a Ph.D. in Analytical Chemistry at Pennsylvania State University (1969) under the guidance of Professor Joseph Jordan. Following appointments at Brookhaven National Laboratory, Stanford University Medical School and the University of Georgia (Athens), in 1977, Dr. Carr joined the faculty at the University of Minnesota where he became Professor of Chemistry in 1981. He has been a consultant to Leeds and Northrup Co., Hewlett-Packard and the 3M Company, and was the founder and first President of ZirChrom Separations Inc. In 1986, he became an Associate Director of the Institute for Advanced Studies in Biological Process Technology at the University of Minnesota. He has been President of the Symposium on Analytical Chemistry in the Environment (1976), founder and first President of the Minnesota Chromatography Forum, and Chairman of the Subdivision of Chromatography and Separation Science of the Analytical Chemistry Division of the American Chemical Society (1988-1989). Prof. Carr has served on the Editorial Advisory Boards of Analytical Chemistry, Talanta, The Microchemical Journal, LC/GC, Journal of Chromatography, Chromatographia and Separation Science and Technology.