1st Edition

Advances in Chromatography Volume 59

Edited By Nelu Grinberg, Peter W. Carr Copyright 2023
    206 Pages 51 Color & 19 B/W Illustrations
    by CRC Press

    206 Pages 51 Color & 19 B/W Illustrations
    by CRC Press

    For six decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known make the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

    • Describes the thermodynamics and kinetics underlying hydrophobic interaction chromatography of proteins.
    • Outlines use of a kinetic model in the predictive modeling of evaporation processes that eliminates the need to know the composition and identity of the chemical constituents in the sample.
    • Explores building and employing QSRR models in cyclodextrin modified high-performance liquid chromatography (HPLC).
    • Reviews chemometric methods commonly paired with comprehensive 2D separations and key instrumental and preprocessing considerations.

    1. Kinetic and Thermodynamic Aspects of Hydrophobic Interaction Chromatography

    Dorota Antos, Wojciech Piątkowski

    2. A Kinetic Model of Evaporation Based on Gas Chromatographic Retention Index: Environmental and Forensic Applications

    Victoria L. McGuffin, Ruth Waddell Smith

    3. Advanced QSRR modelling in β-CD modified RP-HPLC system

    Nevena Djajić, Ana Protić

    4. Comprehensive Two-Dimensional Chromatography with Chemometric Data Analysis

    Caitlin N. Cain, Timothy J. Trinklein, Sonia Schӧneich, Grant S. Ochoa, Sarah C. Rutan, Robert E. Synovec


    Dr. Nelu Grinberg recently retired following an eminent career in research chemistry in the pharmaceutical industry. An internationally known expert in analytical chemistry, with an emphasis on chromatography, spectroscopy, and chiral separations, he was a Distinguished Research Fellow in the Chemical Development Department at Boehringer Ingelheim Pharmaceuticals in Ridgefield, CT until January 2017. Prior to this, he worked for sixteen years in the Analytical Department at Merck Research Laboratories in Rahway, NJ, where he was a Senior Research Fellow. Dr. Grinberg has authored and co-authored over 160 publications, including articles and book chapters, and has lectured and conducted courses worldwide.

    Along with being Co-Editor of the Advances in Chromatography series, he is currently Editor-in-Chief of the Journal of Liquid Chromatography and Related Techniques, and Editor of both the Chromatographic Science book series and the Supramolecular book series. Dr. Grinberg is also a member of the Board of the Connecticut Separation Science Council and was a recipient of a Koltoff Fellowship from The Hebrew University of Jerusalem. In recognition of his achievements, Al. I. Cuza University in Iasi, Romania elected him an Honorary Member of their University Senate.

    Dr. Grinberg obtained his Ph.D. in Chemistry from the Technical University of lasi in Romania. He conducted postdoctoral research with Professor Barry Karger at Northeastern University in Boston, Massachusetts, and with Professor Emanuel Gil-Av at The Weizmann Institute of Science in Rehovot, Israel.

    Peter Carr received his B.S. in Chemistry (1965) from the Polytechnic Institute of Brooklyn where he worked with Professor Louis Meites, and a Ph.D. in Analytical Chemistry at Pennsylvania State University (1969) under the guidance of Professor Joseph Jordan. Following appointments at Brookhaven National Laboratory, Stanford University Medical School and the University of Georgia (Athens), in 1977, Dr. Carr joined the faculty at the University of Minnesota where he became Professor of Chemistry in 1981. He has been a consultant to Leeds and Northrup Co., Hewlett-Packard and the 3M Company, and was the founder and first President of ZirChrom Separations Inc. In 1986, he became an Associate Director of the Institute for Advanced Studies in Biological Process Technology at the University of Minnesota. He has been President of the Symposium on Analytical Chemistry in the Environment (1976), founder and first President of the Minnesota Chromatography Forum, and Chairman of the Subdivision of Chromatography and Separation Science of the Analytical Chemistry Division of the American Chemical Society (1988-1989). Prof. Carr has served on the Editorial Advisory Boards of Analytical Chemistry, Talanta, The Microchemical Journal, LC/GC, Journal of Chromatography, Chromatographia and Separation Science and Technology.