1st Edition

Advances in Isotope Methods for the Analysis of Trace Elements in Man




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ISBN 9780849387302
Published November 29, 2000 by CRC Press
248 Pages

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Book Description

There is increasing evidence that even minute amounts of trace elements can have profound effects on the human body. Advances in Isotope Methods for the Analysis of Trace Elements in Man describes new methods that are being developed to understand normal and abnormal trace element nutrition and metabolism.

This book includes a wealth of practical advice, encompassing all aspects of isotope methodology, such as the latest developments of analysis techniques for both stable and radioactive isotopes, issues in study design, current cost of isotopes, and analysis. It provides both a historical review of what has been done in the past and details of current techniques and applications.

> This state-of-the-art collection from leading experts in the field from Europe and the United States makes a strong case for the practice and advancement of this critical health care tool.

Table of Contents

ADVANCES IN STABLE ISOTOPE METHODOLOGY
History
Using Stable Isotopes to Study Trace Element Metabolism
Stable Isotope Dosage, Preparation, and Administration
Conducting Stable Isotope Tracer Studies
ADVANCES IN RADIOISOTOPE METHODOLOGY
Radioisotopes
Whole-Body Counting Techniques
Body Imaging Techniques
Indirect Measurements of Absorption or Metabolism
Concluding Remarks
TRACER TO TRACEE RATIO FOR
COMPARTMENTAL MODELING OF STABLE
ISOTOPE DATA
Introduction
Single Pool Tracer Kinetics and Measurement
Tracer to Tracee Ratio from Mass Spectrometry
Measurements
Multi Pool Tracer Kinetics and Measurement
The Multiple Tracer Case
A Test of the Endogenous Constant Steady State
Assumption
Software Tool: TTRM
Conclusions
METHODS FOR ANALYSIS OF TRACE ELEMENT
ABSORPTION
Introduction
Iron
Copper
Zinc
Selenium
KINETIC STUDIES OF WHOLE BODY TRACE
ELEMENT METABOLISM
Introduction
General Considerations in Study Design
Compartmental Modeling
Specific Examples of Isotope Turnover Studies
Concluding Remarks
STABLE ISOTOPE METHODS FOR THE
INVESTIGATION OF IRON METABOLISM IN MAN
Introduction
Erythrocyte Incorporation and Iron Absorption
Zinc
Zinc and Copper
Selenium
Chromium
Conclusions
USE OF ISOTOPES IN THE ASSESSMENT OF ZINC STATUS
Introduction
Isotopic Techniques
Conclusions
COPPER STATUS AND METABOLISM STUDIED
WITH ISOTOPIC TRACERS
Introduction
Background
Copper Status
Isotopic Tracers
Conclusions
USE OF STABLE ISOTOPES OF SELENIUM TO
INVESTIGATE SELENIUM STATUS
Introduction
Dietary Selenium and Its Metabolism
The Role of Selenium in the Body
Assessment of Selenium Status and Use of Stable Isotopes
Conclusions
USE OF ISOTOPES FOR STUDIES WITH
MANGANESE, CHROMIUM AND MOLYBDENUM
Manganese
Chromium
Molybdenum
Summary
TRACE ELEMENT STUDIES IN INFANTS AND
PREGNANT OR LACTATING WOMEN
Introduction
Iron
Zinc
Zinc and Copper
Selenium
Chromium
Conclusions
STABLE ISOTOPE STUDIES IN THE ELDERLY
Introduction
Practicalities of Working with Elderly Subjects
Ethical Considerations
Examples of Stable Isotope Studies in the Elderly
Selenium Status of the Elderly
Conclusions
APPLICATIONS OF TRACE ELEMENT STUDIES IN DEVELOPING COUNTRIES: PRACTICAL AND TECHNICAL ASPECTS
Introduction
Applications of Isotope Studies in Developing
Countries
Practical Aspects of Implementing Isotope Studies in
Developing Countries
Technical Aspects of Implementing Isotope Studies in
Developing Countries
Conclusions

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