Advances in Isotope Methods for the Analysis of Trace Elements in Man: 1st Edition (Hardback) book cover

Advances in Isotope Methods for the Analysis of Trace Elements in Man

1st Edition

Edited by Malcolm Jackson, Nicola Lowe

CRC Press

248 pages

Purchasing Options:$ = USD
Hardback: 9780849387302
pub: 2000-11-29
Currently out of stock
$255.00
x
eBook (VitalSource) : 9780429125508
pub: 2000-11-29
from $28.98


FREE Standard Shipping!

Description

There is increasing evidence that even minute amounts of trace elements can have profound effects on the human body. Advances in Isotope Methods for the Analysis of Trace Elements in Man describes new methods that are being developed to understand normal and abnormal trace element nutrition and metabolism.

This book includes a wealth of practical advice, encompassing all aspects of isotope methodology, such as the latest developments of analysis techniques for both stable and radioactive isotopes, issues in study design, current cost of isotopes, and analysis. It provides both a historical review of what has been done in the past and details of current techniques and applications.

> This state-of-the-art collection from leading experts in the field from Europe and the United States makes a strong case for the practice and advancement of this critical health care tool.

Table of Contents

ADVANCES IN STABLE ISOTOPE METHODOLOGY

History

Using Stable Isotopes to Study Trace Element Metabolism

Stable Isotope Dosage, Preparation, and Administration

Conducting Stable Isotope Tracer Studies

ADVANCES IN RADIOISOTOPE METHODOLOGY

Radioisotopes

Whole-Body Counting Techniques

Body Imaging Techniques

Indirect Measurements of Absorption or Metabolism

Concluding Remarks

TRACER TO TRACEE RATIO FOR

COMPARTMENTAL MODELING OF STABLE

ISOTOPE DATA

Introduction

Single Pool Tracer Kinetics and Measurement

Tracer to Tracee Ratio from Mass Spectrometry

Measurements

Multi Pool Tracer Kinetics and Measurement

The Multiple Tracer Case

A Test of the Endogenous Constant Steady State

Assumption

Software Tool: TTRM

Conclusions

METHODS FOR ANALYSIS OF TRACE ELEMENT

ABSORPTION

Introduction

Iron

Copper

Zinc

Selenium

KINETIC STUDIES OF WHOLE BODY TRACE

ELEMENT METABOLISM

Introduction

General Considerations in Study Design

Compartmental Modeling

Specific Examples of Isotope Turnover Studies

Concluding Remarks

STABLE ISOTOPE METHODS FOR THE

INVESTIGATION OF IRON METABOLISM IN MAN

Introduction

Erythrocyte Incorporation and Iron Absorption

Zinc

Zinc and Copper

Selenium

Chromium

Conclusions

USE OF ISOTOPES IN THE ASSESSMENT OF ZINC STATUS

Introduction

Isotopic Techniques

Conclusions

COPPER STATUS AND METABOLISM STUDIED

WITH ISOTOPIC TRACERS

Introduction

Background

Copper Status

Isotopic Tracers

Conclusions

USE OF STABLE ISOTOPES OF SELENIUM TO

INVESTIGATE SELENIUM STATUS

Introduction

Dietary Selenium and Its Metabolism

The Role of Selenium in the Body

Assessment of Selenium Status and Use of Stable Isotopes

Conclusions

USE OF ISOTOPES FOR STUDIES WITH

MANGANESE, CHROMIUM AND MOLYBDENUM

Manganese

Chromium

Molybdenum

Summary

TRACE ELEMENT STUDIES IN INFANTS AND

PREGNANT OR LACTATING WOMEN

Introduction

Iron

Zinc

Zinc and Copper

Selenium

Chromium

Conclusions

STABLE ISOTOPE STUDIES IN THE ELDERLY

Introduction

Practicalities of Working with Elderly Subjects

Ethical Considerations

Examples of Stable Isotope Studies in the Elderly

Selenium Status of the Elderly

Conclusions

APPLICATIONS OF TRACE ELEMENT STUDIES IN DEVELOPING COUNTRIES: PRACTICAL AND TECHNICAL ASPECTS

Introduction

Applications of Isotope Studies in Developing

Countries

Practical Aspects of Implementing Isotope Studies in

Developing Countries

Technical Aspects of Implementing Isotope Studies in

Developing Countries

Conclusions

About the Series

Modern Nutrition

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED060000
MEDICAL / Nutrition