Neuroregulation is a challenging and rapidly developing field that holds the key to many currently intractable medical conditions from nervous and mental diseases to stress-related disorders. Advances in Neuroregulation mirrors the broad scope of research in this area with topics ranging from new concepts on the immune system and on the action of antidepressants to the evolution and development of the autonomic nervous system. In addition, the latest research findings are presented for behavioural disorders and medical conditions such as Parkinson’s disease, Alzheimer’s disease, epilepsy and attention-deficit/hyperactivity disorder. Another area of emphasis is the body's responses to stress and the effect of neuroactive agents in the treatment of stress-related conditions. Many chapters are devoted to the progress being made at the cellular and molecular level, including areas such as: - the conditions for culture of different types of neural cells - conformational diseases and the protein folding problem - vasoactive intestinal polypeptide release from pancreatic islets - the effect of melatonin and corticosterone on macrophages Here, in a book that expands the frontiers of neuroscience, researchers into neuroregulation at the molecular and cellular levels as well as those working at the clinical and systemic levels will find important results relating to their field.


    C Collin, S. H. Parvez, S. Parvez and C. Reiss

    Prof. Minami's contribution to neuroscientific and pharmacological research

    H. Saito, H. Parvez, M. Hirafuji, C. Collin, K. Shimamura, M. Yoshioka, S. Parvez and C. Reiss

    Research on the evolution and development of autonervous system

    K. Nishihara

    The effect of melatonin and corticosterone on the phagocytic function of BALB/c mice macrophages

    C. Barriga, M /. Martin, E. Ortega and A. B. Rodriguez

    Cobalamin deficiency and its dynamic impact on neurotoxicity and oxidative stress in Parkinson's patients in on-off status on L-dopa treatment

    G. A, Qureshi, S. A. Memon, C Collin and S. H. Parvez

    Alzheimer's disease: from bench to bedside

    M. Saeed, P. M. Frossard and H. S. Parvez

    Neuronal responses, sensitivity and fates as a consequence of hypoxia in the immature brain

    J. L. Daval

    Neurodegeneration and neuroprotection: epilepsy and Parkinsonism

    D. Guha

    Oxidative stress and neurotoxicity in Parkinson's patients in on-off phenomena

    G. A. Qureshi, S. A. Memon, C. A. Collin, A. A. Qureshi and S. H. Parvez

    Modulation of dopamine release in the striatum: physiology, pharmacology and pathology

    V. Leviel

    Conditions for culture of different types of neural cells: growth regulation

    E Robert, S. Constantly A. H. Duittoz and T. K. Hevor

    Behavioural and kinetic analysis of locomotion in anxious and non-anxious strains of mice tested on a rotating beam

    J. Negroni, P Venault, C. Bensoussan, C. Cohen-Salmon, E. Lepicard, E Perez-Diaz, R. Jouvent and G. Chapouthier

    Effect of adrenergic and cholinergic agonists on vasoactive intestinal polypeptide release from pancreatic islets of normal and diabetic rats

    E. Adeghate, A. Ponery and H. Parvez

    Conformational diseases and the protein folding problem: role of amino-acid propensity to be embedded in context of specific usage of synonymous codons. Genetic code degeneracy and folding

    J. Solomovici, T. Lesnik, R. Ehrlich, H. Parvez, S. Parvez and C. Reiss

    The pineal gland: Functional connection between melatonin and immune system in birds

    C. Barriga, J, A. Madrid, M. P Terron, R. V Rial J. Cubero, S. D. Paredes, S. Sanchez and A. B. Rodriguez

    Parkinson's disease and neurotransmitters interplay in processes of neurotoxicity and oxidative stress in on and off phenomena

    G A. Qureshi, C. Collin, . A. Memon and S. H. Parvez

    Anxiety-related behavior in juvenile stroke-prone spontaneously hypertensive rats — an animal model of attention-deficit/hyperactivity disorder

    H. Togashi, KA. Ueno, T. Yamaguchi, M. Matsumoto, K. Higuchi, H. Saito and M. Yoshioka

    Characterization of behavioral responses to a -HT releasing drug, /-chloroamphetamine, in mice and the involvement of -HT receptor subtypes in p-chloroamphetamine-induced behavior

    J. Yamada, Y. Sugimoto, M. Ohkura and K. Inoue

    Antidepressant research in the era of functional genomics: Farewell to the monoamine hypothesis

    M. Yamada, K. Takahashi, M. Tsunoda, T. Iwabuchi, S. Kobayashi, N. Tsukahara, T. Nakagawa, M. Awatsu, S. Yamazaki, M. Hirano, H. Ohata, G. Nishioka, K. Kudo, S. Tanaka, K. Kamijima, T. Higuchi, M. Yamada and K. Momose

    Acute and chronic effects of tryptophan and alcohol on serotonin in the locus coeruleus in rats

    K. Hoshi, M. Hayashi and T. Bandoh

    Perospirone hydrochloride: the novel atypical antipsychotic agent with high affinities for -HT, D and -HTiA receptors

    T. Ishibashi and Y. Ohno

    Effects of tandospirone, a novel anxiolytic agent, on human -HTiA receptors expressed in Chinese hamster ovary cells (CHO cells)

    K. Yabuuchi, R, Tagashira and Y Ohno

    Antiparkinsonian actions of a selective -HTIA agonist, tandospirone, in rats

    T. Ishibashi and Y Ohno

    Post-encephalitic parkinsonism: clinical features and experimental model

    A. Ogata, N. Hamaue, M. Minami, I. Yabe, S. Kikuchi, H. Sasaki and K. Tashiro

    Visual searching impairment in patients with major depressive disorder: performance in the Raven coloured progressive matrices test

    N. Nakano, N. Okumura, S. Hayashi, Y Hayashi, S. Saito, N. Sasaki and S. Murakami

    Salivary concentration of -hydroxy try ptamine in patients with bulimia nervosa

    N. Takahashi, N. Hamaue, N. Kuronuma, T. Yoshihara, . Ando, M. Hirafuji, T. Endo, M. Senjo, S. H. Parvez and M. Minami

    Central and peripheral sympathetic controls on catecholamine release in male -month-old SHRSP and WKY investigated by means of -hydrodydopamine injections

    H. Higashino, M. Kawamoto, H. Endo and K. Ooshima

    Effects of serotonin (-HT) on catecholamine secretion from cultured bovine chromaffin cells

    Y. Sugimoto, F. Nishikawa, T. Yoshikawa, T. Noma and J, Yamada

    Enhanced inhibitory effect of -hydroxy try ptamine on nitric oxide production by vascular smooth muscle cells derived from stroke-prone spontaneously hypertensive rats

    M. Hirafuji, Y. Kanai, A. Kawahara, T. Machida, N. Hamaue, H. Saito and M. Minami

    Influence of occlusal support on learning memory and cholinergic neurons in the rat: a mini review

    Y Ikeda, T. Hirai, T. Makiura, T. Terasawa andN. Hamaue

    The ferret: a cytotoxic drug-induced emesis model

    T. Endo, M. Minami, M. Hirafuji, N. Hamaue and S. H. Parvez

    Na+-K+ pump and /-adrenergic responses in smooth muscle

    K. Shimamura, S. Kimura, A. Ohashi, M. Toba, Y Okuno, Y Kanamaru and H. Saito

    Cardiac tissue remodeling and renin-angiotensin system in hypertrophic heart

    H Kawaguchi

    Biofeedback training in clinical settings

    I. Saito and Y. Saito

    Conformational diseases and the protein folding problem: Evidence for species-independent link between protein folding and genetic code degeneracy in ribosomal proteins

    J. Solomovici, T. Lesnik, R. Ehrlich, H. Parvez, S. Parvez and C. Reiss

    Long-term stem cell gene therapy: zinc finger nuclease-boosted gene targeting and synergistic transient regenerative gene therapy

    R. Bertolotti

    SHRSP: A novel field of study

    H. Saito

    Serotonin-mediated neurotransmission in the pyramidal cells of the rat hippocampus

    M. Matsumoto, H. Togashi, T. Kojima, K. Tachibana, S. Ohashi and M. Yoshioka

    The involvement of -HT and -HT receptors in anticancer drug-induced emesis

    M. Minami, T. Endo, M. Hirafuji, T Hiroshige, E. Fukushi, Y. Kang, H. Saito and H. S. Parvez

    Urinary -hydroxyindoleacetic acid excretion and kaolin ingestion after a single administration of cisplatin in the delayed emesis rat model

    Y. Liu, N. Hamaue, T. Endo, M. Hirafuji and M. Minami

    Differences in rotational asymmetry in rats caused by single intranigral injections of -hydroxydopamine, l-methyl--phenylpyridiniumion and rotenone

    M Inden, J. Kondo, Y Kitamura, K. Takata, D. Tsuchiya, K. Nishimura, T. Taniguchi, H. Sawada and S. Shimohama

    Juvenile stroke-prone spontaneously hypertensive rats as an animal model of attention-deficit/hyperactivity disorder

    K.-I. Ueno, H. Togashi, M. Matsumoto, H. Saito andM. Yoshioka

    Intrathecal spermine and spermidine at high-doses induce antinociceptive effects in the mouse capsaicin test

    K. Tan-No, A. Esashi, A. Taira, O. Nakagawasai, F. Niijima, C. Sakurada,

    T. Sakurada and T Tadano

    An experimental rat model of Parkinson's disease induced by Japanese encephalitis virus

    A. Ogata, S. Kikuchi and K. Tashiro

    Blood-brain barrier carrier-mediated transport and metabolism of L-histidine

    E. Sakurai, J. Yamakami, T Sakurada, Y Ochiai and Y Tanaka

    Intracerebral serotonin and catecholamine metabolite concentrations in SART-stressed rats treated with diazepam and fluvoxamine

    E. Kirime, M. Tabuchi, H. Higashino and K. Hitomi

    Protective effect of docosahexaenoic acid against development of hypertension in young stroke-prone spontaneously hypertensive rats. Focus on the sympathoadrenal system and lipid metabolism

    H. Saito, S. Kimura, M. Minami, H. Hayashi, K Shimamura, M. Nemoto and S. H. Parvez

    Expression of acetylcholine in lymphocytes and modulation of an independent lymphocytic cholinergic activity by immunological stimulation

    T. Fujii, K Watanabe, K Fujimoto and K Kawashima

    Central and peripheral sympathetic characteristics in hypertension considered from differences of catecholamine metabolite concentrations in plasma before and after adrenalectomy in male -month-old SHRSP and WKY

    H. Higashino and K Ooshima

    Effects of salicylate on the pharmacokinetics of valproic acid after oral administration of sodium valproate in rats

    S. Ohshiro, N. Hobara, M. Sakau N, Hokama, H. Kameya and M. Sakanashi

    Possible mechanisms of low levels of plasma valproate concentration following simultaneous administration of sodium valproate and meropenem

    N. Hobara, N. Hokama, S. Ohshiro. H. Kameya and M. Sakanashi

    Pressure stress stimulates aortic smooth muscle cell proliferation through angiotensin II receptor mediated signal transduction pathways

    H. Kawaguchi, N. Morita, T. Murakami and K. Iizuka

    Pressure loading-induced mitogen-activated protein kinase activation is enhanced in prehypertensive spontaneously hypertensive rat vasculature

    S. Aiuchi, H. Hosokawa, T. Kambe, K Hagiwara and T. Kubo

    Possible involvement of free radicals in hypertensive organ injury


    Potential roles of interstitial fluid adenosine in the regulation of renal hemodynamics

    A. Nishiyama and Y. Abe

    Renal pelvic pressure and the effect of hemorrhage in rats

    K. Shimamura, H. Kudo, H. Suzuki, S. Kimura, A. Ohashi and H. Saito

    Effects of dopamine, prostaglandins and digitalis on isolated abdominal vagus nerve in rats

    M. Nemoto, T. Endoy M. Minami and H. Saito



    Catherine Collin, Masaru Minami, Hasan Parvez, Hideya Saito, Simone Parvez, Claude Reiss, G.A. Qureshi

    '…this book provides an excellent introduction to this field…This book covers a wide range of common neuropathological disorders and presents them in a way which will be novel to most clinical neuropathologists.' Colin Smith, Neuropathology and Applied Neurobiology, 2005.