This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.
Table of Contents
What is aging. Biological theories of aging. Free radical theory. Mitochondrial dysfunction theory. Error catastrophe theory. Evolutionary theory of aging. Fading electricity theory. Quasi-program theory for aging. Multiple hormone deficiency theory of aging. Oxidation–inflammation theory of aging. Reproductive-cell cycle theory of aging. Telomeres and telomerase theory of aging. Markov Models of aging. Immunological theory of aging. Social theory of aging. Genetic program theory of aging. Psychological theory of aging. Healthy living and its effects on aging. Longevity in aging. Impact of climate on aging. Centenarians in Okinawa. Genetics of the population. Caloric restriction, healthy diet. Staying young at heart. Genetics of aging and longevity. Metabolic programming, exercise, caloric restriction and aging. Premature aging. Progeria and Werner’s syndrome. Stem cell aging in progeria. Oxidative and nitrosative stress and accelerative aging. Progeria: Genetics, and lamin disorder. Molecular aspect of aging. Hematopoietic stem cells aging. Immune system and aging. Sirtuins in aging and age related diseases. AMPK function in aging. Aging mechanisms and lipid changes. Biochemical aspects of aging. GABA(A) receptors in aging. The ubiquitin-proteasome system and aging. Autophagy and aging. Oxidation of potassium channels and aging. Proteins and lipids in aging. Spatial protein quality control and aging. Klotho protein and aging. Glutathione as antioxidant. Neuropeptide Y as an anti-aging agent. Adipokines and aging. Lamins and aging. Sestrins and aging. HDL metabolism and aging. Growth hormone and aging. DNA damage, repair and aging. DNA damage, repair and neurodegenerative diseases. yH2AX molecular marker for DNA damage and aging. DNA repair in organelles and aging. Transcriptional blocking and DNA damage in aging. Microbiota and aging. Neuroscience of aging. Thermal stress in human and aging. Age related diseases. Ischemic heart disease and aging. Endothelial and vascular aging. The aging heart. Age related eye disease. Age related inflammation and osteoarthritis. Aging and musculoskeletal health. Cancer and aging. Sexual health in aging. Sleep disturbance in aging. Anxiety in aging. Female sexuality and aging. Aging and circadian rhythm. Metabolic syndrome and aging. Environmental toxicants and aging. Stem cell and aging. Non-human models for aging studies. Aging modulation in multiple species. Mouse models. Murine genetic models. C. elegans model. S. cerevisiae model. Drosophila model. Pig model. Mammalian hibernation and aging. Neobiosis as a predecessor of mammalian hibernation. Chemosensory and chemosensory systems and aging. Molecular biology of freezing tolerance. Freezing susceptibility in arthropods. Proteomic approach to study mechanisms of aging. Therapeutic approach for facial aging. Integrative medicine research on aging population. Meditation and aging. Life after death: Fact or fiction.
Shamim I. Ahmad received his PhD from Leicester University and has been Lecturer at Nottingham Trent University where he the British Asian Award for "Excellence in Education." He has authored or edited eleven books and dozens of peer reviewed research papers. His research interests are in the field of DNA damage and repair and associated diseases, molecular mechanisms of Fanconi anemia, role of reactive oxygen species (ROS) in health and diseases, skin cancer by sunlight, Anti-AIDS drug development, development of new procedures for treatment of cancer, viral and bacterial infections.