1st Edition

Alcohol, Drugs of Abuse, and Immune Functions

Edited By Ronald R. Watson Copyright 1995
    288 Pages
    by CRC Press

    Substance abusers are an immunocompromised population, vulnerable to a wide array of new and resurgent infectious diseases - in spite of modern treatment. For example, opportunistic infections like tuberculosis are the principal cause of morbidity and mortality in HIV positive patients. Alcohol- and drug-induced disorders are wide-ranging, gaining prominence as the spectrum of emerging diseases broadens.

    Alcohol, Drugs of Abuse, and Immune Functions reviews the role of these immunosuppressants as cofactors in disease. It covers the basic biology and immunology of impairments to defense against infectious disease. Alcohol and drug use is consistently associated with immunosuppression, although it isn't known if it is the substance itself, a metabolite, or an indirect effect that alters disease resistance. This text explores the advances toward answering this question, examines alcohol in different settings, its relationship to important cells, and the effects it can have on vital organs such as the liver and the lungs.

    Immunomodulation Associated with Depression and Stress, E.M. Levy and C. Chancellor-Freeland
    The Effect of Alcohol on the Cellular Immune Function in Animals, C.J. Grossman, G. Roselle, and M. Nienaber
    Immunomodulation by Alcohol in Mice, S.K. Ardestani and R.R. Watson
    Alcohol and Infections of the Lung, G.A. Roselle, C.J. Grossman, M.A. Neinaber, and C.L. Mendenhall
    T Cell Modulations in Human Alcoholics, R.T. Cook
    Alcoholic Liver Disease, Malnutrition, and the Immune Response, A. Chedid
    Modulation of Cytokine Production in Human Lymphoid and Myeloid Cells by Alcohol In Vitro, G. Szabo, P. Mandrekar, B. Verma, and D. Catalano
    Alcohol, Endothelial Cells, and Immunity, P. Borgs, M.H. Witte, and C.L. Witte
    Effect of Prenatal Alcohol Exposure on Hypothalamic-Pituitary-Adrenal Function and Expression of Glucocorticoid-Regulated Genes, E. Redei, I. Halasz, and F. Aird
    Alcohol Metabolism and Its Toxicity: Role of Kupffer Cells and Free Radicals, R.G. Thurman, B.U. Bradford, K.T. Knecht, H.D. Connor, R.P. Mason, U. Adachi, M. Goto, C. Sullivan, and D.T. Forman
    Do Alcohol and Other Substances of Abuse Alter the Natural Evolution and Susceptibility to Human Immunodeficiency Virus-1 Infections? O. Bagastra, R.J. Pomerantz, and A. Kajdacsa-Balla
    Alcohol and ImmunomodulationDuring Murine Acquired Immunodeficiency Syndrome, Y. Wang, D.S. Huang, and R.R. Watson
    Dysregulation in Cytokine Production by Alcohol Consumption: A Cofactor in the Development of Murine Acquired Immunodeficiency Syndrome, Y. Wang and R.R. Watson
    Alcohol Abuse as a Possible Cofactor in the Progression of Acquired Immune Deficiency Syndrome: Do Th-1 and Th-2 Helper T Cell Subsets Play a Role? D.A. Cohen
    The Role of Alcohol on Endocrine-Immune Interactions, Y. Wang and R.R. Watson
    Effects of Cocaine on Certain Macrophage Functions, S.S. Lefkowitz, A. Vaz, and D.L. Lefkowitz


    Ronald R. Watson