6th Edition

Allergens and Allergen Immunotherapy Subcutaneous, Sublingual, and Oral

Edited By Richard F. Lockey, Dennis K. Ledford Copyright 2020
    600 Pages 75 Color & 161 B/W Illustrations
    by CRC Press

    598 Pages 75 Color & 161 B/W Illustrations
    by CRC Press

    598 Pages 75 Color & 161 B/W Illustrations
    by CRC Press

    The sixth edition of Lockey and Ledford's Allergens and Allergen Immunotherapy continues to provide comprehensive coverage of all types of allergens and allergen vaccines, providing clinicians the essential information they need to accurately diagnose and manage all allergic conditions. With new and updated chapters, the sixth edition is the most up-to-date, single resource on allergy and immunotherapy.



    Key Features







    • Completely revised and updated






    • Detailed single source reference on allergy and immunotherapy






    • Reorganized to provide clinicians with essential information to make diagnoses and offer the best treatments

    CONTENTS

    Section I Basic Concepts

    Chapter 1 Historical Perspectives of Allergen Immunotherapy

    David Fitzhugh, Sheldon G. Cohen (Deceased), and Richard Evans III (Deceased)

    Chapter 2 Aeroallergen Sampling

    Estelle Levetin and Josh D. McLoud

    Chapter 3 Definition of an Allergen (Immunobiology)

    Lauren Fine

    Chapter 4 Allergen Nomenclature

    Heimo Breiteneder, Richard Goodman, Martin D. Chapman, and Anna Pomés

    Chapter 5 Immunologic Response to Various Forms of Allergen Immunotherapy

    Umit Murat Sahiner, Mohamed H. Shamji, Sakura Sato, Ozge Soyer, Stephen J Till, Motohiro Ebisawa, Mübeccel Akdis, and Stephen R. Durham

    Chapter 6 In Vivo Testing

    Richard W. Weber

    Chapter 7 Serologic (in vitro) and Component Testing Methods in the Diagnosis of Human Allergic Disease

    Robert G. Hamilton

    Chapter 8 Nasal, Bronchial, Conjunctival, and Food Challenge Techniques and Epicutaneous Immunotherapy of Food Allergy

    Mark W. Tenn, Matthew Rawls, Babak Aberumand, and Anne K. Ellis

    Chapter 9 Local Mucosal Allergic Disease

    Ibon Eguiluz-Gracia, Paloma Campo, and Carmen Rondón

    Section II Allergens: Inhalation, Ingested, and Injected

    Chapter 10 Tree Pollen Allergens

    Rosa Codina, Fernando Pineda, and Ricardo Palacios

    Chapter 11 Grass Pollen Allergens

    Robert E. Esch

    Chapter 12 Weed Pollen Allergens

    Michael Hauser, Gabriele Gadermaier, Sabrina Wildner, Lisa Pointner, Michael Wallner, and Fatima Ferreira

    Chapter 13 Fungal Allergens

    Robert Esch, Jonathan A. Bernstein, and Hari Vijay

    Chapter 14 Mite Allergens

    Enrique Fernández-Caldas, Leonardo Puerta, Luis Caraballo, Victor Iraola, and Richard F. Lockey

    Chapter 15 Cockroach and Other Inhalant Insect Allergens

    Anna Pomés and Coby Schal

    Chapter 16 Mammalian Allergens

    Tuomas Virtanen and Marja Rytkönen-Nissinen

    Chapter 17 Food Allergens

    Anusha Penumarti and Mike Kulis

    Chapter 18 Hymenoptera Allergens

    Rafael I. Monsalve, Te Piao King, and Miles Guralnick

    Chapter 19 Biting Insect and Tick Allergens

    Donald R. Hoffman and Jennifer E. Fergeson

    Chapter 20 Occupational Allergens

    Loida Viera-Hutchins, Andrew M. Smith, and David Bernstein

    Section III Immunotherapy Techniques: Production, Preparation and Administration of Allergen Immunotherapy

    Chapter 21 Manufacturing Pollen and Fungal Extracts

    Robert E. Esch, Rosa Codina, Fernando Pineda, and Ricardo Palacios

    Chapter 22 Manufacturing Arthropod and Mammalian Allergen Extracts

    Enrique Fernández-Caldas, Eva Abel Fernández, Jonathan Kilimajer, and Seong H. Cho

    Chapter 23 Manufacturing Food Extracts

    Natalie A. David, Anusha Penumarti, and Jay E. Slater

    Chapter 24 Regulation of Allergen Extracts in the United States

    Jennifer Bridgewater, Jay E. Slater, and Ronald L. Rabin

    Chapter 25 Manufacturing and Standardizing Allergen Extracts in Europe

    Jørgen Nedergaard Larsen, Christian Gauguin Houghton, Manuel Lombardero Vega, Hendrik Nolte, and Henning Løwenstein

    Chapter 26 Indications for and Preparing and Administering Subcutaneous Allergen Vaccines

    Harold S. Nelson

    Chapter 27 Preparing and Administering Sublingual Allergen Vaccines

    Miguel Casanovas, Jonathan Kilimajer, and Enrique Fernández-Caldas

    Chapter 28 Sublingual and Oral Food Immunotherapy: Indications, Preparation and Administration

    Whitney Block, Sayantani B. Sindher, Vanitha Sampath, and Kari Nadeau

    Chapter 29 Indications for and Preparing and Administering Hymenoptera Vaccines

    David B.K. Golden, Farnaz Tabatabaian, Ulrich Müller-Gierok, and Richard F. Lockey

    Chapter 30 Recombinant and Modified Vaccines and Adjuvants Used for Allergen Immunotherapy

    Jeffrey Stokes and Thomas B. Casale

    Section IV Clinical Application of Allergen Imunotherapy and Biological Therapy for Allergic Diseases

    Chapter 31 Adherence and Cost-Effectiveness of Subcutaneous Immunotherapy and Sublingual Immunotherapy

    Dana V. Wallace and John Oppenheimer

    Chapter 32 Biologics in Allergic Disease

    Tara Saco and Farnaz Tabatabaian

    Chapter 33 Unproven and Epicutaneous and Other Investigational Forms of Immunotherapy

    Haig Tcheurekdjian and Abba I. Terr

    Section V Recognition, Management, and Prevention of Adverse Effects of Allergen Immunotherapy

    Chapter 34 Adverse Effects and Fatalities Associated with Allergen Skin Testing and Subcutaneous Allergen Immunotherapy

    Andrew S. Bagg and Richard F. Lockey

    Chapter 35 Recognition, Prevention, and Treatment of Adverse Effects Associated with Sublingual Immunotherapy

    Giovanni Passalacqua, Diego Bagnasco, and Walter Canonica

    Chapter 36 Recognition, Prevention, and Treatment of Adverse Effects Associated with Oral Allergen Immunotherapy

    Jennifer A. Dantzer and Robert A. Wood

    Chapter 37 Instructions and Consent Forms for Subcutaneous Allergen Immunotherapy

    Shiven S. Patel, Linda Cox, and Richard F. Lockey

    Chapter 38 Recognition, Treatment, and Prevention of Systemic Allergic Reactions and Anaphylaxis

    Emma Westermann-Clark, Stephen F. Kemp, and Richard D. deShazo

    Biography

    Richard F. Lockey, MD, MS, is Distinguished University Health Professor, Professor of Medicine, Pediatrics and Public Health, Joy McCann Culverhouse Chair of Allergy and Immunology, and Director, Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, Florida.





    Dennis K. Ledford, MD, is Professor of Medicine and Pediatrics, Mabel and Ellsworth Simmons Professor, University of South Florida Morsani College of Medicine, and Chief, VA Section of Allergy/Immunology, James A. Haley Veterans' Hospital, Tampa, Florida.