1st Edition
Allergic Contact Dermatitis Chemical and Metabolic Mechanisms
336 Pages
by
CRC Press
336 Pages
by
CRC Press
Also available as eBook on:
Allergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and skin metabolism and includes discussion of the xenobiotics themselves. It answers questions such as: How does sensitisation relate to protein reactivity and levels of metabolism? How we can identify potential hazards in... Read more
1. Allergic Contact Dermatitis to Small Molecules 2. Percutaneous Penetration of Xenobiotics 3. Enzymes and Mechanisms of Xenobiotic Metabolism 4. Enzymes and Pathways of Xenobiotic Metabolism in Skin 5. Xenobiotics as Skin Sensitizers: Metabolic Activation and Detoxication, and Protein-Binding Mechanisms 6. Protein-hapten Binding and Immunorecognition Events During the Sensitisation and Elicitation Stages of ACD 7. Conclusion: Basic Considerations for Xenobiotic-Derived ACD and a Modified MHC-Peptide-Hapten Hypothesis
Biography
Camilla Smith (Levers Brothers, UK), Sharon Hotchkiss (Imperial College of Medicine, England, UK)
