Allergic Contact Dermatitis
Chemical and Metabolic Mechanisms
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Allergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and skin metabolism and includes discussion of the xenobiotics themselves. It answers questions such as: How does sensitisation relate to protein reactivity and levels of metabolism? How we can identify potential hazards in food, cosmetics and pharmaceuticals etc?
In a world where people are becoming increasingly aware of their allergies, this up to date one-stop reference will prove an invaluable addition to the shelves of any researcher in academia, government, regulatory bodies, public health officials and, of course, the food, cosmetics and pharmaceuticals industries will find the book to be of particular relevance.
Table of Contents
1. Allergic Contact Dermatitis to Small Molecules 2. Percutaneous Penetration of Xenobiotics 3. Enzymes and Mechanisms of Xenobiotic Metabolism 4. Enzymes and Pathways of Xenobiotic Metabolism in Skin 5. Xenobiotics as Skin Sensitizers: Metabolic Activation and Detoxication, and Protein-Binding Mechanisms 6. Protein-hapten Binding and Immunorecognition Events During the Sensitisation and Elicitation Stages of ACD 7. Conclusion: Basic Considerations for Xenobiotic-Derived ACD and a Modified MHC-Peptide-Hapten Hypothesis