376 pages | 99 B/W Illus.
Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing those already working in the field with specific reference information. This title provides in-depth chapters on basic principles of allosterism and its significance at GABAA, 5HT3, nicotinic, and GABAB receptors, ionotropic and metabotropic receptors for glutamate, muscarinic receptors and alpha 2 adrenoceptors to provide a firm foundation to the subject.
"…This book provides valuable theoretical and practical information on receptor allosterism and its potential importance in the design and development of novel therapeutics. It is a unique offering in stressing the importance of allosterism in drug discovery. This makes it a particularly important contribution for industrial and academic scientists and clinicians with an interest in new approaches for designing safer, more selective, and efficacious drugs."
-Doody's Review Services
BASIC PRINCIPLES. Allosteric Modulation of Receptor Function. Characteristics of Allosterism in Drug Action. Predicting Dose-Response Curve Behavior: Mathematical Models of Allosteric Ligand-Receptor Interactions. IONOTROPIC RECEPTORS. Allosteric Modulation of GABAA Receptors: A Pharmacology of Sleep, Anxiety and Memory. Allosteric Interactions at the NMDA Receptor Channel Complex. 5-HT3 Receptors. Nicotinic Receptors. G-PROTEIN COUPLED RECEPTORS. Allosteric Modulation of G protein-coupled Receptors. Adenosine Receptor. Allosteric Modulators of Group III Metabotropic Glutamate Receptors as Novel Therapeutics. Allosteric Modulation of Gamma-Aminobutyric Acid B (GABAB) Receptors. Allosteric Interactions at GABAB and Related G-Protein-Coupled Receptors. Muscarinic Receptors: Targeting Allosteric Modulation by the Development and Application of the Radiolabeled Allosteric Agent [3H]dimethyl-W84. Alpha 2 Adrenoceptors: Physiology, Pharmacology and Allosteric Modulation.