Allosteric Receptor Modulation in Drug Targeting: 1st Edition (Hardback) book cover

Allosteric Receptor Modulation in Drug Targeting

1st Edition

Edited by Norman G. Bowery

CRC Press

376 pages | 99 B/W Illus.

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Hardback: 9780824727918
pub: 2006-06-19
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Description

Offering a wide array of illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems-helping those new to the subject understand the importance of allosterism and providing those already working in the field with specific reference information. This title provides in-depth chapters on basic principles of allosterism and its significance at GABAA, 5HT3, nicotinic, and GABAB receptors, ionotropic and metabotropic receptors for glutamate, muscarinic receptors and alpha 2 adrenoceptors to provide a firm foundation to the subject.

Reviews

"…This book provides valuable theoretical and practical information on receptor allosterism and its potential importance in the design and development of novel therapeutics. It is a unique offering in stressing the importance of allosterism in drug discovery. This makes it a particularly important contribution for industrial and academic scientists and clinicians with an interest in new approaches for designing safer, more selective, and efficacious drugs."

-Doody's Review Services

Table of Contents

BASIC PRINCIPLES. Allosteric Modulation of Receptor Function. Characteristics of Allosterism in Drug Action. Predicting Dose-Response Curve Behavior: Mathematical Models of Allosteric Ligand-Receptor Interactions. IONOTROPIC RECEPTORS. Allosteric Modulation of GABAA Receptors: A Pharmacology of Sleep, Anxiety and Memory. Allosteric Interactions at the NMDA Receptor Channel Complex. 5-HT3 Receptors. Nicotinic Receptors. G-PROTEIN COUPLED RECEPTORS. Allosteric Modulation of G protein-coupled Receptors. Adenosine Receptor. Allosteric Modulators of Group III Metabotropic Glutamate Receptors as Novel Therapeutics. Allosteric Modulation of Gamma-Aminobutyric Acid B (GABAB) Receptors. Allosteric Interactions at GABAB and Related G-Protein-Coupled Receptors. Muscarinic Receptors: Targeting Allosteric Modulation by the Development and Application of the Radiolabeled Allosteric Agent [3H]dimethyl-W84. Alpha 2 Adrenoceptors: Physiology, Pharmacology and Allosteric Modulation.

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED072000
MEDICAL / Pharmacy