Recently, the implication of biocompatible nanotechnologies has set the stage for an evolutionary leap in diagnostic imaging and therapy. In this scope, the book presents a comprehensive overview of the possible causes, diagnostic criteria, and treatment assessments of amyotrophic lateral sclerosis, and presents the recent findings using innovative, highly sensitive, and novel diagnostic molecular imaging approaches. In addition, the book offers new perspectives of an innovative and recently developed approach in neuroimaging using surface-enhanced nanoimaging microscopy, which can be a promising technique for early diagnosis and treatment assessments.
Table of Contents
Clinical Features of Amyotrophic Lateral Sclerosis
What Is Amyotrophic Lateral Sclerosis?
ALS Signs and Symptoms
The Different Types of ALS
ALS: Clinical Case Studies
What Environmental Factors Are Suspect in ALS?
Toxic Metals and Solvents
The Possible Effects of Exercise or Pesticides
Environmental Influences of Viruses
BMAA Neurotoxic Effects
Are Toxins in Seafood Causing ALS?
Diagnostic Criteria of Amyotrophic Lateral Sclerosis
Steps in the Diagnosis of ALS
Electrophysiology in the Revised EEC
Nerve Conduction Studies
Clinical Features in the Diagnosis of ALS
Inconsistent Clinical Features
ALS Electrophysiological Features
ALS Neuroimaging Features
Perspectives of Neuronanomedicine
Nanomedicine and Neurological Disorders
CNS Neuroprotective Potentials
Nanocarriers and CNS-Targeted Drug Delivery
Applications Based on Cell-Mediated Drug Delivery
CNS Nano-Based Diagnostic Approaches
Inflammation and Neurodegeneration: CanWe Measure Neuroprotection and Repair through Imaging Techniques? Constraints in the Treatment of Neurodegenerative Diseases: Future Directions
Novel Therapeutic Approaches
Conventional Treatments for ALS
Occupational Therapy and Supportive Therapy
Cell Replacement Therapy and Future Challenges
Stem Cell Transplantation Therapy
Clinical Applications of Cell Transplant Therapy
Trials of Other Cell Sources for Stem Cell Therapy
Stem Cell Therapy: Clinical Trials
Induced Pluripotent Stem (iPS) Cell Therapy
Gene Therapy and Future Challenges
Prof Lina Machtoub received her Ph.D. from the University of Tokyo, Japan, 2002, after she was granted honourable research fellowship from the Japanese Government for 5 years. In 2003, she joined Max Planck Institute, Germany, after she was granted a research award from Alexander von Humboldt foundation. In the institute, she worked on the development of combined ultra-high magnetic field and optical imaging. In 2006, she became visiting scientist at Harvard Medical University, Boston. Since 2007, she has participated in several clinical research projects focusing on the development of clinical multimodal imaging techniques based on nanobiotechnology. In 2009, she joined the Medical University of Innsbruck, Austria, where she conducted research on developing highly sensitive, diagnostic, and targeted imaging probes with implications of in vivo imaging-targeted contrast agents and multifunctional imaging. Her main project was the development of innovative diagnostic approach "surface-enhanced coherent anti-Stokes Raman scattering (SECARS) microscopy" using nanoscale contrast agents for magnetic resonance.