Amyotrophic Lateral Sclerosis: Advances and Perspectives of Neuronanomedicine, 1st Edition (Hardback) book cover

Amyotrophic Lateral Sclerosis

Advances and Perspectives of Neuronanomedicine, 1st Edition

By Lina Machtoub, Yu Kasugai

Jenny Stanford Publishing

158 pages | 4 Color Illus. | 37 B/W Illus.

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Hardback: 9789814463041
pub: 2015-12-14
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pub: 2016-01-05
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Recently, the implication of biocompatible nanotechnologies has set the stage for an evolutionary leap in diagnostic imaging and therapy. In this scope, the book presents a comprehensive overview of the possible causes, diagnostic criteria, and treatment assessments of amyotrophic lateral sclerosis, and presents the recent findings using innovative, highly sensitive, and novel diagnostic molecular imaging approaches. In addition, the book offers new perspectives of an innovative and recently developed approach in neuroimaging using surface-enhanced nanoimaging microscopy, which can be a promising technique for early diagnosis and treatment assessments.

Table of Contents

Clinical Features of Amyotrophic Lateral Sclerosis

What Is Amyotrophic Lateral Sclerosis?

ALS Signs and Symptoms

The Different Types of ALS

ALS: Clinical Case Studies

Environmental Factors

What Environmental Factors Are Suspect in ALS?

Toxic Metals and Solvents

The Possible Effects of Exercise or Pesticides

Environmental Influences of Viruses

BMAA Neurotoxic Effects

Are Toxins in Seafood Causing ALS?

Diagnostic Criteria of Amyotrophic Lateral Sclerosis

Steps in the Diagnosis of ALS

Electrophysiology in the Revised EEC

Nerve Conduction Studies

Clinical Features in the Diagnosis of ALS

Inconsistent Clinical Features

ALS Electrophysiological Features

ALS Neuroimaging Features

Perspectives of Neuronanomedicine

Nanomedicine and Neurological Disorders

CNS Neuroprotective Potentials

Nanocarriers and CNS-Targeted Drug Delivery

Applications Based on Cell-Mediated Drug Delivery

CNS Nano-Based Diagnostic Approaches

Inflammation and Neurodegeneration: CanWe Measure Neuroprotection and Repair through Imaging Techniques? Constraints in the Treatment of Neurodegenerative Diseases: Future Directions

Novel Therapeutic Approaches

Conventional Treatments for ALS

Occupational Therapy and Supportive Therapy

Cell Replacement Therapy and Future Challenges

Stem Cell Transplantation Therapy

Clinical Applications of Cell Transplant Therapy

Trials of Other Cell Sources for Stem Cell Therapy

Stem Cell Therapy: Clinical Trials

Induced Pluripotent Stem (iPS) Cell Therapy

Gene Therapy and Future Challenges

About the Authors

Prof Lina Machtoub received her Ph.D. from the University of Tokyo, Japan, 2002, after she was granted honourable research fellowship from the Japanese Government for 5 years. In 2003, she joined Max Planck Institute, Germany, after she was granted a research award from Alexander von Humboldt foundation. In the institute, she worked on the development of combined ultra-high magnetic field and optical imaging. In 2006, she became visiting scientist at Harvard Medical University, Boston. Since 2007, she has participated in several clinical research projects focusing on the development of clinical multimodal imaging techniques based on nanobiotechnology. In 2009, she joined the Medical University of Innsbruck, Austria, where she conducted research on developing highly sensitive, diagnostic, and targeted imaging probes with implications of in vivo imaging-targeted contrast agents and multifunctional imaging. Her main project was the development of innovative diagnostic approach "surface-enhanced coherent anti-Stokes Raman scattering (SECARS) microscopy" using nanoscale contrast agents for magnetic resonance.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Neurology
MEDICAL / Radiology & Nuclear Medicine
SCIENCE / Life Sciences / Neuroscience