Amyotrophic lateral sclerosis or motor neurone disease is one of the most debilitating and devastating of the neurological diseases. The only comprehensive textbook available on the topic, this completely reorganized and expanded new edition examines all aspects of ALS from pathology to patient care and provides the reader with a ready reference to help with the difficulties encountered in patient diagnosis and treatment. Undoubtedly an important work in the field, this book will be of great interest to clinical neurologists and trainees, and to all those concerned with the care of people with ALS.
The Spectrum of Motor Neuron Disorders. Epidemiology of Amyotrophic Lateral Sclerosis. Neuroimaging in ALS. Motor Unit Number Estimation in ALS. The corticomotoneuronal system in ALS. Conventional Neurophysiology in ALS. The Neuropsychology of ALS. Familial motor neuron diseases other than ALS. ALS Genetics with Mendelian Inheritance. Modifying Genes in ALS. From Genetic Defects to Molecular Pathogenesis of Memory and Movement Disorders. Transgenic Mouse and Mutagenesis Models. Apoptotic Cell Death Pathways in Amyotrophic Lateral Sclerosis: A Review. Ageing and Neurodegeneration. Neurotrophic Factors. Axonal transport and ALS. Mitochondrial dysfunction and energy metabolism in ALS. Therapeutic Trials in ALS: Past, Present and Future. Palliative care and quality of life with ALS