Analytical and Practical Aspects of Drug Testing in Hair: 1st Edition (Hardback) book cover

Analytical and Practical Aspects of Drug Testing in Hair

1st Edition

Edited by Pascal Kintz

CRC Press

382 pages | 100 B/W Illus.

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pub: 2006-08-30
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Description

Many advances have been made since the publication of Drug Testing in Hair. The mid-1990s witnessed the progress in cannabis detection while the late 1990s focused on benzodiazepines detection and the applications in doping control. In more recent years, toxicologists centered on the detection in hair of a single exposure and the related applications in drug-facilitated crimes. Presenting these topics as well as the latest findings from the international community, Analytical and Practical Aspects of Drug Testing in Hair reviews all new developments, the validation of analytical procedures, and the interpretation of data.

Written by well-known, international authors, this comprehensive reference provides practical coverage of the best drug testing techniques and examines the drugs themselves. Some of the applications discussed include doping, drug-facilitated crime investigating, workplace testing, and the granting of drivers' licenses. The authors describe specific drugs, such as opiates, cocaine, and cannabis, and discuss the different testing methods for them. The book also covers postmortem toxicology, pitfalls created by passive exposure, and testing for metals, including inductively coupled plasma spectrometry (ICP-MS), hair multielementary analysis, and the new speciation analysis.

A complete, up-to-date resource that explains numerous drug testing techniques, Analytical and Practical Aspects of Drug Testing in Hair provides useful information for toxicologists, forensic scientists, sports medicine specialists, and pathologists.

Table of Contents

DRUG INCORPORATION INTO HAIR

Hair Physiology

Drug Incorporation Routes

Mechanisms of Binding

General Discussion

Concluding Remarks

References

PASSIVE EXPOSURE, DECONTAMINATION PROCEDURES, CUTOFFS, AND BIAS: PITFALLS IN THE INTERPRETATION OF HAIR ANALYSIS RESULTS FOR COCAINE USE

Introduction

Historical Concerns for Passive Exposure in Hair Analysis

Mechanisms for Incorporation of Drugs into Hair

Drugs in the Environment

Decontamination Procedures

Cutoffs and Why They Matter

Bias in Hair Testing

Conclusions

Acknowledgments

References

OPIOIDS TESTING IN HAIR

Introduction

Opiates

Conclusions

References

HAIR ANALYSIS FOR COCAINE

Introduction

Analytical Methodologies

Quality Control

Interpretation of Results

Acknowledgments

Abbreviations

References

DETERMINATION OF CANNABINOIDS IN HUMAN HAIR

Introduction

Metabolism, Incorporation of Cannabinoids into Hair

Analytical Techniques for the Detection of Cannabinoids Decontamination Processes

Issues to Be Considered

Criteria for Obtaining a Cannabis-Positive Hair-Test Result

Controlled Studies: Empirical Data Analysis of a Large Sample of

Hair Specimens

Reported Concentrations of Cannabinoids in Hair

Conclusions

References

AMPHETAMINE DETERMINATION IN HAIR

Introduction

Preamble

Amphetamine Determination

Conclusion

References

PHARMACEUTICALS IN HAIR

Introduction

Discussion and Conclusion

References

SCREENING STRATEGIES IN HAIR ANALYSIS ON DRUGS

Introduction

Immunochemical Screening in Hair Analysis

Screening and Confirmation by GC-MS/MS

Multianalyte Screening Using LC-MS/MS

Crime Cases Solved by Screening Hair Using LC-MS/MS

Conclusions

References

CLINICAL APPLICATIONS OF HAIR ANALYSIS

Introduction

Hair Analysis in Psychiatric Patients

Hair Analysis in Epileptic Management

Hair Analysis as Evidence of Prenatal and Postnatal Exposure to

Drugs and Tobacco

Hair Nicotine as a Marker of Active and Passive Exposure to Tobacco

Drug Addiction and Opiate-Maintenance Programs

Therapeutic Drug Monitoring

References

HAIR IN POSTMORTEM TOXICOLOGY

Introduction

Methodological Aspects

Strategies in Postmortem Work

Conclusions and Take-Home Message

References

DETECTION OF DOPING AGENTS IN HUMAN HAIR

Introduction

Procedures

Detection of Doping Agents

Discussion

Conclusions

References

APPLICATIONS OF HAIR IN DRUG-FACILITATED CRIME EVIDENCE

Introduction

Analytical Strategy

Case Reports

Discussion

Conclusion

References

APPLICATION OF HAIR IN DRIVING-LICENSE REGRANTING

Introduction

Sensitivity of Drug Abuse Detection: Comparison between

Urine and Hair Analysis

Hair Sampling for Drug Analysis

Manipulation of Drug Concentrations in Hair

Hair Analysis for Regranting Driver's License

Regulations in Other Countries

Conclusions

References

ALCOHOL MARKERS IN HAIR

General Problems in Detection of Chronic Alcohol Abuse

Fatty Acid Ethyl Esters (FAEE)

Ethylglucuronide (EtG)

Combined Use of FAEE and EtG

Benzoylecgonine Ethyl Ester (Cocaethylene, BE-Et)

Further Possibilities

Conclusions

References

WORKPLACE DRUG TESTING USING HAIR SAMPLES

Introduction

Sample Collection

Screening Procedures

Sample Preparation: Washing and Extraction Methods

Confirmation by Mass Spectrometry

Testing Body Hair Samples in Workplace Testing

Conclusion

References

METALS

Introduction

Hair Metal Incorporation

Hair Washing Procedure and Sample Preparation

Hair Elements Analytical Methods

Metal Hair Reference Values

Hair Metal Analysis Interpretation

Hair Metal Analysis Results

Metal Hair Certified Reference Material

Elements

Conclusion

Acknowledgments

References

About the Series

International Forensic Science and Investigation

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
LAW041000
LAW / Forensic Science
MED071000
MEDICAL / Pharmacology
MED084000
MEDICAL / Sports Medicine