1st Edition

Animal Cell Technology From Biopharmaceuticals to Gene Therapy

    564 Pages 129 B/W Illustrations
    by Taylor & Francis

    506 Pages 129 B/W Illustrations
    by Taylor & Francis

    Animal Cell Technology: from Biopharmaceuticals to Gene Therapy provides a comprehensive insight into biological and engineering concepts related to mammalian and insect cell technology, as well as an overview of the applications of animal cell technology. Part 1 of the book covers the Fundamentals upon which this technology is based and covers the science underpinning the technology. Part 2 covers the Applications from the production of therapeutic proteins to gene therapy.  The authors of the chapters are internationally-recognized in the field of animal cell culture research and have extensive experience in the areas covered in their respective chapters.

    1. Introduction to Animal Cell Technology 
    2. Animal Cells: Basic Concepts 
    3. Cloning and Expression of Heterologous Proteins in Animal Cells 
    4. Cell Metabolism and its Control in Culture 
    5. Culture Media for Animal Cells 
    6. Post-Translational Modification of Recombinant Proteins 
    7. Mechanisms of Cell Proliferation and Cell Death in Animal Cell Culture In Vitro 
    8. Mathematical Models for Growth and Product Synthesis in Animal Cell Culture 
    9. Bioreactors for Animal Cells 
    10. Monitoring and Control of Cell Cultures 
    11. Animal Cell Separation 
    12. Product Purification Processes
    13. Quality Control of Biotechnological Products 
    14. Regulatory Aspects 
    15. Intellectual Property 
    16. Recombinant Therapeutic Proteins 
    17. Monoclonal Antibodies 
    18. Viral Vaccines: Concepts, Principles and Bioprocesses 
    19. Bioinsecticides 
    20. Cell Therapies and Stem Cells 
    21. Gene Therapy


    Leda R. Castilho - Cell Culture Engineering Laboratory, Chemical Engineering Program - CPPE, Federal University of Rio do Janeiro, Brazil

    Angela Maria Moraes - School of Chemical Engineering, Department of Biotechnological Processes, State University of Campinas, Brazil

    Elisabeth F. P. Augusto - Institute of Technological Research of the State of Sao Paulo, Brazil

    Michael Butler - Department of Microbiology, University of Manitoba, Canada

    "…an excellent introduction to all aspects of animal cell culture."

    Biotechnology Advances