Animal Models in Toxicology  book cover
3rd Edition

Animal Models in Toxicology

ISBN 9781466554283
Published July 17, 2015 by CRC Press
1168 Pages 60 B/W Illustrations

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Book Description

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding.

This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

Table of Contents

Shayne Cox Gad

The Mouse

Shayne Cox Gad, Charlie Clifford, and Dawn Goodman

The Rat

Mark D. Johnson, Shayne Cox Gad, and Christopher J. Kemper

The Hamster

Shayne Cox Gad and Frederick G. Hess

The Guinea Pig

Shayne Cox Gad and John Peckham (deceased)


Clare M. Salamon and Shayne Cox Gad

The Ferret

Daniel E. McLain and Shayne Cox Gad

The Dog

Shayne Cox Gad, Mark Morse, and Christopher J. Kemper


Mark D. Walker, Michael V. Templin, John C. Bernal, Stewart B. Jacobson, and Shayne Cox Gad

The Minipig

Shayne Cox Gad and Alain Stricker-Krongrad

Alternative Species

Shayne Cox Gad

Clinical Pathology of Laboratory Animals

Niraj K. Tripathi and Robert L. Hall

Telemetry in Nonclinical Drug Safety Assessment Studies

R. Dustan (Dusty) Sarazan

Molecular Imaging Techniques in Laboratory Animals

Zheng J. Wang, Ting-Tung A. Chang, Richard Slauter, Stephen R. Porter, Avinash Srivatsan, and Xiaoyuan Chen

Genetically Modified Animal Models

JoAnn Schuh

Model Selection and Scaling (Allometry)

Shayne Cox Gad

Susceptibility Factors

Shayne Cox Gad

Laws, Regulations, and Guidelines for Animal Care and Use in Research

Charles B. Spainhour and Laurie M. Serfilippi

Necropsy and Gross Pathology

Charles B. Spainhour

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Edited by

Shayne Cox Gad, PhD, DABT, is the principal of Gad Consulting Services in Raleigh, North Carolina. He has more than 38 years of broad-based experience in toxicology, drug, device development, document preparation, statistics, and risk assessment, having previously been the director of toxicology and pharmacology for Synergen, director of medical affairs technical support system services for Becton Dickinson, and senior director of product safety and pharmacokinetics for G.D. Searle. He is past president of the American College of Toxicology and Roundtable of Toxicology Consultants and a board-certified toxicologist. Dr. Gad has published 47 books and more than 350 chapters, papers, and abstracts.


"…should be in every toxicology laboratory that performs research involving animals. No other book … provides the same breadth and depth of information as found here…"
—Michele T. Pritchard, PhD, University of Kansas Medical Center in Doody’s Book Reviews