As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.
The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.
Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.
Table of Contents
Autoimmune diabetes, present status of knowledge in animals and the implications for the understanding and preventing of human type 1 diabetes. Diabesity in ob/ob and db/db mice: the use of these models for studies of diabetes and obesity in humans. The Zucker diabetic fatty rat: lessons from leptin receptor deficiency. The Goto-Kaizaki diabetic rat evolved by selective inbreeding. Then NSY mouse, an animal model with human type 2 diabetes with polygenic inheritance. The new Zealand obese mouse, a polygenic model of type 2 diabetes, metabolic abnormalities without single genetic mutation. The OLETF rat, spontaneous interaction of diabetes and obesity and the associated nephropathy. The JCR: Lacp rat a model of obesity, insulin resistance, and atherosclerosis cardiovascular disease. The neonatally sterptozotocin induced diabetic rat: a family of type 2 diabetes like animal models. The rhesus monkey (Macaca Mulatta) a model for the study of gradual development of diabetes on ad libitum nutrition. The desert gerbil, Psammomys obesus: molecular mechanisms of the nutritionally induced diabetes, and its prevention; validity for study of factors underlying the prevalent diabetes epidemic, related to affluent nutrition. The C57BL6J mouse, a model of diet induced type 2 diabetes, hypertension, and obesity. The obese, spontaneously hypertensive SHROB, Koletzky rat: a model for human metabolic syndrome. The diabetic minipig, sharing physiologic and digestion characteristics with the human. The spontaneously diabetic Torii (SDT) rat with human resembling retinopathy lesions.