Animal Models of Diabetes: Frontiers in Research, 2nd Edition (Hardback) book cover

Animal Models of Diabetes

Frontiers in Research, 2nd Edition

Edited by Eleazar Shafrir

CRC Press

384 pages | 4 Color Illus. | 48 B/W Illus.

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Hardback: 9780849395345
pub: 2007-04-05
eBook (VitalSource) : 9780429126130
pub: 2007-04-05
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As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.

The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.

Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.


"In general, the book provides excellent background and specific information on each model . . . The appropriate audience for this book is anyone who wants, or needs, to learn about common animal models of diabetes."

– Leanne Alworth, in Laboratory Animal Practitioner, December 2008, Vol. 41, No. 4

“… is composed of 17 chapters and provides useful information regarding the selection of an appropriate diabetic model anima. The book lists various types of diabetic models and covers the major models of type-1 and type-2 diabetes. … each chapter includes a description of the model animal’s history of establishment. The chapters also provide the genomic background, biological characteristics, mechanisms of incidence, pathogenesis of complications, and availability of each model animal. These descriptions are based on experimental evidence, and include numerous citations of up-to-date references. The number of tables and diagrams is adequate … source of histopathological information on diabetic model animals. … this book is valuable as a general reference of researchers hesitant about the selection of diabetic model animals for experiments. Overall, this book is a good guide when selecting diabetic model animals. I recommend those veterinary pathologists read this book before beginning experiments using diabetic model animals.”

— Akira Yabuki, Laboratory of Veterinary Anatomy, Kagoshima University, Japan, in Veterinary Pathology, 2007

"Overall, this well-written text consolidates the body of knowledge gained from an in vivo experimentation designed to elucidate the pathophysiology of diabetes . . . will certainly serve as a valuable resource. I would recommend this book to anyone with an interest in learning more about current research in the field of diabetes."

– In Journal of the American Association for Laboratory Animal Science, November 2007, Vol. 46, No. 6

Table of Contents

Rat Models of Type 1 Diabetes, Genetics Environment, and Autoimmunity, J.P. Mordes, P. Poussier, A.A. Rossini, E.P. Blankenhorn, and D.L. Greiner

The NOD Mouse and its Related Strains, H. Taniguchi, S. Makino, and H. Ikegami

Obesity/Diabetes in Mice with Mutations in Leptin or Leptin Receptor Genes, S. Chua, Jr., L. Herberg, and E.H. Leiter

The Zucker Diabetic Fatty (ZDF) Rat—Lessons from a Leptin Receptor Defect Diabetic Model, R.G. Peterson

The Goto–Kakizaki Rat, C.-G. Östenson

The New Zealand Obese Mouse: Polygenic Model of Obesity, Glucose Intolerance, and the Metabolic Syndrome, B.C. Fam and S. Andrikopoulos

The JCR:LA-cp Rat: Animal Model of the Metabolic Syndrome Exhibiting Micro- and Macrovascular Disease, J.C. Russell, S.E. Kelly, and S.D. Proctor

The SHROB (Koletsky) Rat as a Model for Metabolic Syndrome, R.J. Koletsky, R.A. Velliquette, and P. Ernsberger

OLETF Rats: Model for the Metabolic Syndrome and Diabetic Nephropathy in Humans, K. Kawano

Neonatally Streptozotocin-Induced (n-STZ) Diabetic Rats: A Family of Type 2 Diabetes Models, B. Portha, J. Movassat, C. Cuzin-Tourrel, D. Bailbe, M. H. Giroix, P. Serradas, M. Dolz, and M. Kergoat

The Rhesus Monkey (Macaca mulatta) Manifests all Features of Human Type 2 Diabetes, B.C. Hansen and X.T. Tigno

Pigs in Diabetes Research, with Special Focus on Type 2 Diabetes Research, M.O. Larsen and B. Rolin

Psammomys Obesus: Nutritionally Induced Insulin Resistance, Diabetes, and Beta Cell Loss, E. Ziv, R. Kalman, and E. Shafrir

The Spontaneously Diabetic Torii (SDT) Rat with Retinopathy Lesions Resembling Those of Humans, M. Shinohara, T. Masuyama, and A. Kakehashi

Cohen Diabetic Rat, S. Weksler-Zangen, E. Orlanski, and D.H. Zangen

KK and KKA y Mice: Models of Type 2 Diabetes with Obesity, S. Taketomi

Animal Models to Study Obesity and Type 2 Diabetes Induced by Diet, T. Coskun, Y. Chen, D. Sindelar, and M. Heiman Index

About the Series

Frontiers in Animal Diabetes Research

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Endocrinology & Metabolism
MEDICAL / Pharmacology
MEDICAL / Research